Genetic Mechanisms of Obesity
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 25 March 2026 | Viewed by 142
Special Issue Editor
Interests: childhood obesity; disparity; genetics; non-invasive biomarkers; microbiome
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Obesity is a complex, multifactorial condition and a major global public health concern, contributing to an increased risk of type 2 diabetes, cardiovascular disease, certain cancers, sleep apnea, and a range of social and psychological complications. While behavioral, environmental, and metabolic factors play important roles, genetic influences are estimated to account for 40–70% of obesity susceptibility.
Recent advances in genomic technologies, including genome-wide association studies (GWAS), whole-genome and exome sequencing, epigenomic profiling, transcriptomics, and other multi-omics approaches, have revealed a wide array of genetic mechanisms underlying obesity. These include rare and common variants affecting appetite regulation, energy expenditure, lipid and glucose metabolism, adipogenesis, and gut microbiota composition. Epigenetic modifications such as DNA methylation and histone modifications, as well as gene–environment interactions, are increasingly recognized as important contributors to obesity onset and progression.
This Special Issue, entitled “Genetic Mechanisms of Obesity”, seeks to showcase cutting-edge research that advances our understanding of how genetic and epigenetic factors drive obesity risk and pathophysiology. We welcome original research articles, reviews, and meta-analyses focusing on molecular pathways, functional genomics, gene regulation, systems biology, and translational studies that link genetic mechanisms to prevention, diagnosis, and treatment strategies.
Dr. Thangiah Geetha
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- obesity
- genetic mechanisms
- epigenetics
- DNA methylation
- genome-wide association studies
- multi-omics
- transcriptomics
- foundtional genomics
- gene–environment interactions
- childhood obesity
- energy metabolism
- precision medicine
- gut microbiota
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