Utilizing Multi-Omics to Investigate Neurodegenerative Disorders
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Neurogenomics".
Deadline for manuscript submissions: 25 October 2025 | Viewed by 91
Special Issue Editor
Special Issue Information
Dear Colleagues,
Neurodegenerative disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Dementia with Lewy bodies (DLB), Frontotemporal dementia (FTD), and Amyotrophic Lateral Sclerosis (ALS), present significant challenges due to their complex and multifactorial nature. Understanding the intricate molecular mechanisms driving these diseases requires comprehensive approaches that integrate data across multiple biological layers.
The advent of multi-omics technologies—encompassing genomics, transcriptomics, proteomics, metabolomics, and epigenomics—has revolutionized our ability to explore disease biology. By combining these diverse datasets, researchers can uncover novel biomarkers, identify therapeutic targets, and enhance disease classification. Multi-omics integration also offers a systems-level perspective on the pathological pathways contributing to neurodegeneration, leading to a deeper understanding of disease progression and heterogeneity.
This Special Issue of Genes invites original research articles, reviews, and methodological advancements focused on applying multi-omics approaches to investigate neurodegenerative disorders. We encourage submissions that explore the following topics:
- Integrative analyses linking genetic, transcriptomic, and proteomic data to uncover molecular signatures of neurodegeneration.
- Biomarker discovery and validation using omics datasets.
- Pathway enrichment and network-based analyses to identify dysregulated biological processes.
- Novel computational approaches for multi-omics data integration and interpretation.
- Studies investigating the role of genetic variants and regulatory mechanisms in disease progression.
By bringing together interdisciplinary research, this Special Issue aims to foster collaboration and advance our understanding of the complex biology underlying neurodegenerative diseases. We look forward to receiving contributions that push the boundaries of multi-omics research and offer insights into potential therapeutic strategies.
Dr. Muhammad Ali
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegeneration
- central nervous system
- diagnosis
- prognosis
- biomarkers
- predictive modeling
- brain
- cerebrospinal fluid
- plasma
- multi-omics
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