Genetic Aspects of Autoimmune Diseases

Dear Colleagues,

Autoimmune diseases (ADs) result from the complex interaction of genetic susceptibility factors, environmental triggers and epigenetic interactions, leading to the breakdown of immune tolerance. Individuals with a family history of AD are at higher risk of developing autoimmune conditions, implicating that genetic factors play a significant role in the development of AD. Genes such as the Human Leukocyte Antigen are among the first genes identified to be strongly linked to AD. Understanding how genetics contribute to the development of AD, including genetic predisposition and the polygenic basis of AD, will shed light on disease etiology and lead to development of targeted therapies.

The main objective of this Special Issue is to provide an update on the discovery of genetic variants and polygenic basis nature of AD, as well as relevant genetic studies that may lead to precision medicine approaches to treat AD.

Authors are invited to submit original research and/or systematic review articles.

Dr. Cheuk Wun Li
Guest Editor

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