Epigenetic Regulation in Tumors

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".

Deadline for manuscript submissions: 25 August 2025 | Viewed by 416

Special Issue Editor


E-Mail Website
Guest Editor
Molecular Virology Department, Stefan S. Nicolau Institute of Virology, Bucharest, Romania
Interests: epigenetic mechanisms; oncogenesis; viral induced oncogenesis; DNA methylation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cancer is a multifactorial and a complex disease characterized at molecular level not only by genetic mutations but also by epigenetic alterations. As already known, epigenetics plays a pivotal role in tumor development, progression, and resistance to therapy. Dysregulated mechanisms such as DNA methylation, histone modifications, and non-coding RNAs contribute to oncogenic transformation. Epigenetic modifications are influenced by environmental factors (e.g., pollution), lifestyle habits and infections, particularly viral infections. Moreover, the dynamic interplay between epigenetic modifications and the tumor microenvironment influences cancer cell plasticity, immune evasion, and metastasis. In the 'omics' era, studying the altered epigenome of cancer cells  could reveal effective biomarkers for precision medicine and guide the development of new anticancer therapies. Although RNA epigenetics is still an underexplored field, several studies have shown that RNA modifications can impact gene expression and drug response. Artificial intelligence has the potential to accelerate the discovery of tumor epigenetic biomarkers and the development of personalized treatments.

Key topics covered in this issue include, but are not limited to: epigenetic mechanisms driving tumorigenesis, novel epigenetic biomarkers for cancer diagnosis and prognosis, therapeutic targeting of the epigenome, epigenetic interactions with the tumor microenvironment, multi-omics and bioinformatics approaches in cancer epigenetics.

Dr. Anca Botezatu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer epigenetics
  • epigenetic mechanisms
  • tumor microenvironment
  • epigenetic biomarkers
  • multi-omics and bioinformatics

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers

This special issue is now open for submission.
Back to TopTop