Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Pharmacogenetics".
Deadline for manuscript submissions: 20 April 2026 | Viewed by 19
Special Issue Editors
Interests: multifactorial diseases; psoriasis; atopic dermatitis; rheumatoid arthritis; pharmacogenetics/pharmacogenomics; molecular biology and functional analysis of genes
Special Issues, Collections and Topics in MDPI journals
Interests: pharmacogenomics; molecular pharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent advances in genomics and epigenomics have significantly enhanced our understanding of autoimmune diseases. Genome-wide association studies and next-generation sequencing have uncovered numerous genetic loci associated with disease susceptibility and treatment response. However, the modest proportion of explained heritability highlights the importance of rare variants, gene–gene interactions, and non-coding regulatory elements. Beyond genetics, pharmacoepigenomic studies reveal how DNA methylation, histone modifications, and non-coding RNAs modulate drug metabolism and immune regulation, influencing both therapeutic efficacy and adverse reactions. Integrating these molecular insights with clinical phenotypes enables a more refined stratification of patients, facilitating the transition from population-based treatment to individualized care.
In this Special Issue entitled "Pharmacogenomics and Pharmacoepigenomics in Autoimmune Diseases: How Close We Are to Personalised Medicine", we invite contributions that explore genetic and epigenetic determinants of drug response, functional characterization of pharmacogenomic loci, and multi-omic approaches to therapeutic optimization. By combining pharmacogenetic, transcriptomic, and epigenomic data, this collection aims to understand the molecular landscape governing drug efficacy and toxicity, ultimately advancing the implementation of precision medicine in autoimmune disorders.
Dr. Yiannis Vasilopoulos
Prof. Dr. Ioannis S. Vizirianakis
Guest Editors
Manuscript Submission Information
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Keywords
- pharmacogenomics
- pharmacoepigenomics
- drug efficacy
- drug toxicity
- molecular pharmacology
- autoimmune diseases
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