Genetic Insights and Molecular Pathways in Alzheimer's Disease: Unveiling the Complexity of Neurodegeneration
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: 10 April 2026 | Viewed by 100
Special Issue Editors
Interests: genetic and molecular pathways; driving Alzheimer’s disease; amyloid-β; tau pathology; neuroinflammation; mitochondrial dysfunction; targeted therapies; precision medicine; neurodegeneration
Interests: neurosciences; neurodegeneration; amyotrophic lateral sclerosis (ALS); extracellular vesicles; human induced pluripotent stem cells (hiPSCs); organ-on-a-chip (OoC)
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Special Issue Information
Dear Colleagues,
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by progressive cognitive decline and complex molecular underpinnings. Genetic factors, including mutations in APP, PSEN1, and PSEN2, as well as risk variants such as APOE ε4, play pivotal roles in amyloid-β aggregation and tau pathology. Recent genome-wide association studies (GWAS) have uncovered additional susceptibility loci linked to immune response, lipid metabolism, and synaptic function, highlighting the polygenic nature of AD. At the molecular level, dysregulation of neuroinflammatory pathways, mitochondrial dysfunction, oxidative stress, and impaired proteostasis converge to accelerate neuronal loss. Advances in transcriptomics, epigenetics, and multi-omics approaches are further elucidating the interplay between genetic predisposition and environmental factors, offering insights into disease heterogeneity and therapeutic targets. Understanding these interconnected pathways is essential for the development of personalized medicine strategies aimed at early detection, prevention, and precision therapies in AD.
Dr. Marta Rusek
Dr. Alessandro Romano
Guest Editors
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Keywords
- Alzheimer’s disease
- neurodegeneration
- amyloid-β pathology
- tau pathology
- APOE ε4
- APP
- PSEN1
- PSEN2
- GWAS
- neuroinflammation
- mitochondrial dysfunction
- oxidative stress
- proteostasis
- precision medicine
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