Genetics of Host–Pathogen Interactions
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 25 October 2025 | Viewed by 19
Special Issue Editors
Interests: host–pathogen interactions; cell signaling; transcriptomics; proteomics; immune response; inflammation; SARS-CoV-2
Interests: transcriptomics; immunogenomics; microRNA; animal genomics; immune response; inflammation; molecular biology; microbiota; metabolomics; proteomics; salmonellosis
Special Issue Information
Dear Colleagues,
Host–pathogen interactions are fundamental to understanding the biology of infectious diseases. Pathogens have evolved sophisticated mechanisms to exploit host resources, while hosts have developed complex immune defenses to counteract these threats. Understanding the genetic factors that govern these interactions is essential for unraveling disease mechanisms and developing effective interventions in both human and veterinary medicine, agriculture, and ecology.
This Special Issue aims to highlight advances in the genetic and genomic study of these complex interactions across diverse systems, including humans, animals, plants, and microbes. Topics may include genetic determinants of host resistance, pathogen adaptation, immune modulation, co-evolutionary processes, and host–pathogen–microbiome interactions.
Traditionally, studies of host–pathogen dynamics focused on phenotypic traits and candidate genes. The advent of high-throughput sequencing and computational biology has transformed the field, enabling genome-wide analyses and discovery of novel genetic interactions that shape disease outcomes.
Recent advances include single-cell omics, CRISPR-based functional screens, and system biology approaches. These tools are providing deeper insights into complex traits and real-time evolutionary responses during infection.
We invite original research articles, reviews, and methodological papers that explore genetic mechanisms underlying host–pathogen interactions. Contributions addressing emerging infectious diseases or using innovative models and methods are particularly encouraged.
Dr. Transito Garcia-Garcia
Dr. Sara Zaldívar López
Guest Editors
Manuscript Submission Information
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Keywords
- pathogen virulence factors
- infection susceptibility
- immune evasion
- genomics of infectious diseases
- host–pathogen co-evolution
- host–pathogen dynamics
- microbiome–host interactions
- emerging infectious diseases
- crispr and gene editing in host–pathogen studies
- transcriptomics and gene expression profiling
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