Genetic and Genomic Analysis of Inflammatory Bowel Disease
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 15 April 2026 | Viewed by 30
Special Issue Editors
Interests: inflammatory bowel disease; transcriptomics; genomics; bioinformatics; single-cell transcriptomics
Special Issue Information
Dear Colleagues,
Inflammatory bowel disease (IBD), comprising Crohn’s disease and ulcerative colitis, is a chronic immune-mediated condition driven by genetic predisposition, environmental triggers, gut microbiota dysbiosis, and dysregulated mucosal immunity. Although biological and small-molecule therapies have revolutionized treatment, variable response and secondary loss of efficacy remain major clinical challenges.
This Special Issue on “Genetic and Genomic Analysis of Inflammatory Bowel Disease” seeks to integrate discoveries from human integrative multi-omics to better understand disease mechanisms and improve precision therapy across all advanced IBD treatments.
Anti–tumor necrosis factor (TNF-α) agents were the first biologics to transform IBD care, followed by anti-integrin antibodies and interleukin (IL)12/23 and IL23 inhibitors. Recently, the use of Janus kinase (JAK) inhibitors has offered oral alternatives with novel mechanisms. Yet primary non-response, secondary loss of effect, and heterogeneity in outcomes persist, highlighting the need for molecular predictors.
Modern genome-wide profiling, polygenic risk score, epigenetic mapping, bulk and single-cell RNA sequencing, and integrative bioinformatics are uncovering immune cell signatures, barrier dysfunction pathways, and therapy-specific molecular programs. These approaches promise minimally invasive biomarkers to guide selection and monitoring of anti-TNF, anti-integrin, anti-IL12/23, anti-IL23, and JAK inhibitors.
We invite original research and reviews on genetic susceptibility, multi-omics biomarkers, functional genomics, single-cell studies, epigenetic and proteomic profiling, and computational models that predict treatment response and personalize IBD management.
Dr. Mario Gorenjak
Dr. Gregor Jezernik
Guest Editors
Manuscript Submission Information
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Keywords
- inflammatory bowel disease
- crohn’s disease
- ulcerative colitis
- genomics
- transcriptomics
- biologicals
- small-molecule drugs
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