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  • Review
  • Open Access
46 Citations
10,597 Views
68 Pages

Impact of COVID-19 First Wave on Psychological and Psychosocial Dimensions: A Systematic Review

  • Viola Filindassi,
  • Chiara Pedrini,
  • Clarissa Sabadini,
  • Mirko Duradoni and
  • Andrea Guazzini

9 March 2022

A systematic review of the literature investigating the effects of the COVID-19 pandemic on psychological and psychosocial factors was completed. Published literature was examined using electronic databases to search psychosocial factors such as beli...

  • Review
  • Open Access
46 Citations
15,373 Views
20 Pages

A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19

  • Ankita Khataniar,
  • Upasana Pathak,
  • Sanchaita Rajkhowa and
  • Anupam Nath Jha

26 January 2022

Drug repurposing is a more inexpensive and shorter approach than the traditional drug discovery and development process. The concept of identifying a potent molecule from a library of pre-existing molecules or an already approved drug has become a go...

  • Article
  • Open Access
38 Citations
7,677 Views
24 Pages

25 July 2022

This paper presents the findings of an exploratory study on the continuously generating Big Data on Twitter related to the sharing of information, news, views, opinions, ideas, knowledge, feedback, and experiences about the COVID-19 pandemic, with a...

  • Article
  • Open Access
32 Citations
9,561 Views
13 Pages

18 September 2021

Coronavirus disease (COVID-19) is an illness caused by a novel coronavirus family. One of the practical examinations for COVID-19 is chest radiography. COVID-19 infected patients show abnormalities in chest X-ray images. However, examining the chest...

  • Article
  • Open Access
29 Citations
3,947 Views
9 Pages

30 June 2024

Background: Over the past 100 years, the discovery of antibiotics is regarded as one of the most significant advances in medical research and has saved millions of lives. However, the emergence of antimicrobial-resistant bacteria has significantly re...

  • Article
  • Open Access
27 Citations
11,403 Views
11 Pages

31 May 2021

The lack of therapies for moderate COVID-19 syndrome prompted us to use a standardized polyphenolic green tea extract rich in catechins during the lockdown due to the pandemic in Italy (Autumn 2020). Catechins are powerful antioxidant, anti-inflammat...

  • Review
  • Open Access
26 Citations
9,370 Views
19 Pages

The Role of Serology Testing to Strengthen Vaccination Initiatives and Policies for COVID-19 in Europe

  • Paolo Bonanni,
  • Rafael Cantón,
  • Dipender Gill,
  • Philippe Halfon and ,
  • Uwe G. Liebert,
  • Katya A. Nogales Crespo,
  • Jaime J. Pérez Martín and
  • Claudia M. Trombetta
  • + 3 authors+ 0 author

26 June 2021

This review explores and positions the value of serology testing to support current immunization policies and the broader policy response to the coronavirus disease 2019 (COVID-19) crisis in Europe. We applied an exploratory approach to analysing exi...

  • Article
  • Open Access
25 Citations
24,292 Views
12 Pages

16 August 2021

Ibuprofen is a common over-the-counter drug taken for pain relief. However, recent studies have raised concerns about its potential toxic effect with coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronaviru...

  • Review
  • Open Access
24 Citations
47,176 Views
12 Pages

Effectiveness of COVID-19 Vaccination on Transmission: A Systematic Review

  • Anouk Oordt-Speets,
  • Julia Spinardi,
  • Carlos Mendoza,
  • Jingyan Yang and ,
  • Graciela Morales,
  • John M. McLaughlin and
  • Moe H. Kyaw
  • + 2 authors+ 0 author

23 September 2023

Vaccination against infectious disease affords direct protection from vaccine-induced immunity and additional indirect protection for unvaccinated persons. A systematic review was conducted to estimate the indirect effect of COVID-19 vaccination. Fro...

  • Review
  • Open Access
22 Citations
9,530 Views
13 Pages

25 April 2022

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. The clinical presentations of the SARS-CoV-2 infection are widely variable and treatment strategies for COVID-19 are dependent on the infection phase. Timing the right treatment for th...

(This article belongs to the Topic Acute Respiratory Viruses Molecular Epidemiology)
  • Article
  • Open Access
21 Citations
5,106 Views
18 Pages

Computational Study of the Therapeutic Potential of Novel Heterocyclic Derivatives against SARS-CoV-2

  • Benjamin Ayodipupo Babalola,
  • Tosin Emmanuel Adetobi,
  • Oluwamayowa Samuel Akinsuyi,
  • Otunba Ahmed Adebisi and
  • Elizabeth Oreoluwa Folajimi

16 December 2021

Severe Acute Respiratory Syndrome Coronavirus- 2 (SARS-CoV-2), including the recently reported severe variant B.1.617.2, has been reported to attack the respiratory tract with symptoms that may ultimately lead to death. While studies have been conduc...

(This article belongs to the Topic Broad-Spectrum Antiviral Agents)
  • Article
  • Open Access
19 Citations
4,417 Views
10 Pages

Risk Markers of COVID-19, a Study from South-Lebanon

  • Mohamed Chakkour,
  • Ali Salami,
  • Dana Olleik,
  • Israa Kamal and ,
  • Fatima Y. Noureddine,
  • Ali El Roz and
  • Ghassan Ghssein
  • + 2 authors+ 0 author

27 June 2022

Background: COVID-19, caused by the novel coronavirus SARS-CoV-2, was declared by WHO in early 2020 as a worldwide pandemic. Several known risk markers are associated with COVID-19 morbidity and mortality, including age, gender, and diseases, such as...

  • Article
  • Open Access
18 Citations
7,906 Views
13 Pages

Imported SARS-CoV-2 Variants of Concern Drove Spread of Infections across Kenya during the Second Year of the Pandemic

  • Carolyne Nasimiyu,
  • Damaris Matoke-Muhia,
  • Gilbert K. Rono,
  • Eric Osoro and ,
  • Daniel O. Ouso,
  • J. Milkah Mwangi,
  • Nicholas Mwikwabe,
  • Kelvin Thiong’o,
  • Jeanette Dawa and
  • Samuel O. Oyola
  • + 18 authors+ 13 authors

5 May 2022

Using classical and genomic epidemiology, we tracked the COVID-19 pandemic in Kenya over 23 months to determine the impact of SARS-CoV-2 variants on its progression. SARS-CoV-2 surveillance and testing data were obtained from the Kenya Ministry of He...

(This article belongs to the Topic Acute Respiratory Viruses Molecular Epidemiology)
  • Article
  • Open Access
18 Citations
30,070 Views
17 Pages

22 March 2022

Gut microflora dysbiosis affects the majority of individuals after COVID-19, contributing to both gastro-intestinal (GI) and non-GI symptoms. Natural phytochemicals have reported anti-viral properties and favourable effects on inflammatory and oxidat...

  • Article
  • Open Access
18 Citations
5,087 Views
24 Pages

23 May 2024

One of the most pressing challenges associated with SARS treatment is the emergence of new variants that may be transmissible, causing more severe disease or being resistant to the current standard of treatment. This study aimed to identify potential...

  • Article
  • Open Access
17 Citations
5,898 Views
10 Pages

13 July 2021

The interaction of the spike (S) glycoprotein of SARS-CoV-2 with angiotensin-converting enzyme 2 (ACE2) correlates with increased virus transmissibility and disease severity in humans. Two strategies may be considered for preventive or treatment purp...

  • Article
  • Open Access
17 Citations
4,011 Views
17 Pages

18 August 2021

The 2019 coronavirus (COVID-19) outbreak has drastically changed people’s lifestyles and forced them to adopt new behaviors. To assess Italians’ reported compliance to the behavioral provisions issued by the Italian Ministry of Health against the COV...

  • Systematic Review
  • Open Access
16 Citations
7,861 Views
52 Pages

1 August 2023

Background: The COVID-19 pandemic disrupted global healthcare systems, requiring rapid adaptations. This study evaluates the impact on health systems and services in India during the peak of the first wave and its aftermath. It analyses disruptions,...

(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities)
  • Article
  • Open Access
16 Citations
24,292 Views
11 Pages

Mortality of Post-COVID-19 Condition: 2025 Update

  • Giuseppe Lippi and
  • Fabian Sanchis-Gomar

14 January 2025

Background: The coronavirus disease 2019 (COVID-19) pandemic has generated profound health, societal, and economic consequences, which have been further compounded by long-term sequelae commonly referred to as post-COVID-19 or long-COVID syndrome. Un...

(This article belongs to the Section Long COVID and Post-Acute Sequelae)
  • Viewpoint
  • Open Access
16 Citations
8,480 Views
12 Pages

COVID-19 Response in Zimbabwe: The Need for a Paradigm Shift?

  • Itai Chitungo,
  • Tafadzwa Dzinamarira,
  • Nigel Tungwarara,
  • Munashe Chimene and ,
  • Solomon Mukwenha,
  • Edward Kunonga,
  • Godfrey Musuka and
  • Grant Murewanhema
  • + 3 authors+ 0 author

29 June 2022

Zimbabwe reported its first case of coronavirus disease 2019 (COVID-19) on 20 March 2020 and the country’s response has largely adhered to international protocols. From the outset of the pandemic, most control measures were premised upon knowle...

  • Article
  • Open Access
16 Citations
5,134 Views
34 Pages

19 June 2022

Coronavirus disease 2019 (COVID-19) has been causing negative impacts on various sectors in Sri Lanka, as a result of the public health interventions that the government had to implement in order to reduce the spread of the disease. Equivalent work c...

  • Article
  • Open Access
16 Citations
4,533 Views
14 Pages

Examining Risk Perception and Coping Strategies of Senior High School Teachers in Ghana: Does COVID-19-Related Knowledge Matter?

  • James Boadu Frimpong,
  • Edmond Kwesi Agormedah,
  • Medina Srem-Sai,
  • Frank Quansah and
  • John Elvis Hagan

23 May 2022

Previous research has established the link between COVID-19 risk perception and the coping behaviors of teachers in different countries. However, these studies have revealed inconsistent result patterns. Moreover, little is known about the role of CO...

  • Brief Report
  • Open Access
16 Citations
4,625 Views
7 Pages

1 June 2021

We aimed to determine Malaysia’s COVID-19 reproduction number and herd immunity threshold through a mathematical epidemiology synthesis. Using time-series incidence data, the time-dependent reproduction number (Rt) was yielded over time during the CO...

  • Article
  • Open Access
16 Citations
9,441 Views
16 Pages

Low Selectivity Indices of Ivermectin and Macrocyclic Lactones on SARS-CoV-2 Replication In Vitro

  • Christine Chable-Bessia,
  • Charlotte Boullé,
  • Aymeric Neyret,
  • Jitendriya Swain and ,
  • Mathilde Hénaut,
  • Peggy Merida,
  • Nathalie Gros,
  • Alain Makinson,
  • Sébastien Lyonnais and
  • Delphine Muriaux
  • + 6 authors+ 1 author

12 January 2022

Ivermectin was first approved for human use as an endectocide in the 1980s. It remains one of the most important global health medicines in history and has recently been shown to exert in vitro activity against SARS-CoV-2. However, the macrocyclic la...

  • Review
  • Open Access
15 Citations
11,719 Views
34 Pages

16 January 2023

In the ongoing COVID-19 pandemic, digital technologies have played a vital role to minimize the spread of COVID-19, and to control its pitfalls for the general public. Without such technologies, bringing the pandemic under control would have been tri...

  • Article
  • Open Access
15 Citations
11,779 Views
29 Pages

30 December 2021

For fighting the COVID-19 pandemic, countries used control measures of different severity, from “relaxed” to lockdown. Drastic lockdown measures are considered more effective but also have a negative impact on the economy. When comparing...

(This article belongs to the Topic Burden of COVID-19 in Different Countries)
  • Article
  • Open Access
14 Citations
7,282 Views
16 Pages

30 May 2022

The COVID-19 global pandemic necessitated adequate compliance to safe and effective vaccinations developed against the disease. Vaccination reduces high infection, morbidity, and mortality rates, develops herd immunity, and alleviates overburdened he...

  • Article
  • Open Access
14 Citations
20,956 Views
12 Pages

KERRA, Mixed Medicinal Plant Extracts, Inhibits SARS-CoV-2 Targets Enzymes and Feline Coronavirus

  • Supaphorn Seetaha,
  • Phatcharin Khamplong,
  • Panatda Wanaragthai,
  • Thitinan Aiebchun and ,
  • Siriluk Ratanabunyong,
  • Sucheewin Krobthong,
  • Yodying Yingchutrakul,
  • Jatuporn Rattanasrisomporn and
  • Kiattawee Choowongkomon
  • + 4 authors+ 0 author

16 May 2022

The COVID-19 pandemic affects all parameters, especially healthcare professionals, drugs and medical supplies. The KERRA is a mixed medicinal plant capsule that is used for the treatment of patients with high fever, with food and drug administration...

  • Article
  • Open Access
13 Citations
6,273 Views
12 Pages

20 February 2023

The COVID-19 pandemic has resulted in rapid, unprecedented changes in the lives of children and adolescents worldwide. During the first year in the COVID-19 pandemic German schools were partially closed. The restrictions to limit the pandemic can be...

(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities)
  • Article
  • Open Access
13 Citations
5,593 Views
14 Pages

Analysis of COVID-19 Risk Perception and Its Correlates among University Students in Ghana

  • Frank Quansah,
  • Stephen Kofi Anin,
  • John Elvis Hagan,
  • Edmond Kwesi Agormedah and ,
  • Prince Oduro,
  • Medina Srem-Sai,
  • James Boadu Frimpong and
  • Thomas Schack
  • + 3 authors+ 0 author

11 August 2022

Monitoring students’ risk perception forms part of emergency management during public health emergencies. Thus, public risk perception generally triggers attitudes, emotional responses, and prevention behaviors, which affect the evolution of em...

(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities)
  • Article
  • Open Access
13 Citations
7,612 Views
11 Pages

27 September 2021

Introduction: While mitigation procedures are needed to prevent the continuous spread of COVID-19, they may, in turn, negatively impact individuals’ mental health. Therefore, the current study aimed to investigate the relationships between loneliness...

  • Review
  • Open Access
12 Citations
7,291 Views
22 Pages

16 August 2023

During COVID-19, self-directed learning, contrasted with standardized learning, became a necessary and promoted learning method in public schools—one potentially supportive of mental health regularly in public schools through the use of online...

(This article belongs to the Special Issue COVID and Post-COVID: The Psychological and Social Impact of COVID-19)
  • Article
  • Open Access
12 Citations
3,241 Views
15 Pages

29 October 2023

The goal of this study is to analyze associations between COVID-19 transmission and meteorological indicators in cities of the Black Sea region of Turkey, located specifically in the dampest area, with excess rainfall and recurring fog. In particular...

  • Review
  • Open Access
12 Citations
11,617 Views
22 Pages

Monoclonal Antibodies as Potential COVID-19 Therapeutic Agents

  • Jacek Plichta,
  • Piotr Kuna and
  • Michał Panek

12 May 2022

The COVID-19 pandemic continues to cause tremendous loss of life and put massive strain on the functioning of societies worldwide. Despite the cataclysmic proportions of this viral outbreak, as of yet, no effective curative treatment is available. CO...

  • Article
  • Open Access
12 Citations
13,602 Views
21 Pages

24 January 2024

(1) Background: The coronavirus disease 2019 (COVID-19) pandemic significantly affected the population worldwide, with varying responses implemented to control its spread. This study aimed to compare the epidemic data compiled by the World Health Org...

(This article belongs to the Special Issue Analysis of Modeling and Statistics for COVID-19)
  • Article
  • Open Access
12 Citations
4,888 Views
13 Pages

Anti-SARS-CoV-2 Activity of Adamantanes In Vitro and in Animal Models of Infection

  • Sun-Young Lim,
  • Zhiru Guo,
  • Ping Liu,
  • Lindsay G. A. McKay and ,
  • Nadia Storm,
  • Anthony Griffiths,
  • Ming Da Qu,
  • Robert W. Finberg,
  • Mohan Somasundaran and
  • Jennifer P. Wang
  • + 5 authors+ 0 author

28 October 2022

Coronavirus disease 2019 (COVID-19) has had devastating effects worldwide, with particularly high morbidity and mortality in outbreaks on residential care facilities. Amantadine, originally licensed as an antiviral agent for therapy and prophylaxis a...

  • Review
  • Open Access
12 Citations
15,793 Views
20 Pages

28 July 2022

A complete response to the challenge of COVID-19 requires diagnosis, prevention, and treatment strategies. Until recently, the treatment arm has included largely ineffective, often unproven medications with minimal impact on disease outcomes. The ear...

  • Article
  • Open Access
12 Citations
4,964 Views
14 Pages

14 October 2021

COVID-19 patients suffer from hypercoagulation and activated immune-inflammatory pathways. The current study examined the relationship between specific complements and coagulation abnormalities associated with chest CT scan anomalies (CCTAs) and peri...

  • Article
  • Open Access
12 Citations
7,015 Views
15 Pages

16 October 2021

In this study, we developed a compartmental SIRD model to analyze and forecast the transmission dynamics of the COVID-19 pandemic in Bangladesh during the third wave caused by the Indian delta variant. With the help of the nonlinear system of differe...

(This article belongs to the Topic Burden of COVID-19 in Different Countries)
  • Review
  • Open Access
11 Citations
8,524 Views
19 Pages

A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein Mutations

  • Aganze Gloire-Aimé Mushebenge,
  • Samuel Chima Ugbaja,
  • Nonkululeko Avril Mbatha,
  • Rene B. Khan and
  • Hezekiel M. Kumalo

16 September 2023

The emergence of SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has sparked intense research on its spike protein, which is essential for viral entrance into host cells. Viral reproduction and transmission, host immune response regulati...

(This article belongs to the Topic Host Response against SARS-CoV-2 Infection: Implications for Diagnosis, Treatment and Vaccine Development)
  • Article
  • Open Access
11 Citations
6,038 Views
15 Pages

Determinants of COVID-19 Vaccine Uptake and Hesitancy among Healthcare Workers in Tanzania: A Mixed-Methods Study

  • Maryam A. Amour,
  • Innocent B. Mboya,
  • Harrieth P. Ndumwa,
  • James T. Kengia and ,
  • Emmy Metta,
  • Belinda J. Njiro,
  • Kasusu Klint Nyamuryekung’e,
  • Lwidiko E. Mhamilawa,
  • Elizabeth H. Shayo and
  • Albino Kalolo
  • + 9 authors+ 4 authors

19 May 2023

The novel Coronavirus disease 2019 (COVID-19) presents a major threat to public health but can be prevented by safe and effective COVID-19 vaccines. Vaccine acceptance among healthcare workers (HCWs) is essential to promote uptake. This study, aimed...

  • Review
  • Open Access
11 Citations
17,930 Views
27 Pages

23 December 2022

Industries worldwide have faced continuous burdens since the beginning of the COVID-19 pandemic, while adjusting to rapidly changing rules and regulations. Industries need to be prepared to remain operational and productive in the face of current and...

  • Article
  • Open Access
11 Citations
5,157 Views
23 Pages

26 November 2022

The declaration of the coronavirus disease 2019 (COVID-19) pandemic led to the enforcement of national lockdowns in several countries. While lockdowns are generally effective in containing the spread of infectious diseases, they are associated with n...

  • Article
  • Open Access
11 Citations
4,371 Views
16 Pages

Gender and COVID-19 Vaccine Disparities in Cameroon

  • Adidja Amani,
  • Tatiana Mossus,
  • Fabrice Zobel Lekeumo Cheuyem,
  • Chanceline Bilounga and ,
  • Pamela Mikamb,
  • Jonas Basseguin Atchou,
  • Aude Perine Minyem Ngombi,
  • Armanda Nangmo,
  • Yannick Kamga and
  • Anne-Cécile Zoung-Kanyi Bissek
  • + 7 authors+ 2 authors

30 November 2022

Six months following the national launch of COVID-19 vaccinations in Cameroon, only 1.1% of the target population was fully vaccinated, with women representing less than one-third of the vaccinated population regardless of age, profession, or comorbi...

  • Article
  • Open Access
11 Citations
4,293 Views
13 Pages

30 March 2022

The availability of accurate information has proved fundamental to managing health crises. This research examined pandemic data provided by 198 countries worldwide two years after the outbreak of the deadly Coronavirus in Wuhan, China. We compiled an...

  • Article
  • Open Access
11 Citations
5,441 Views
12 Pages

Neuropsychological Outcomes of COVID-19: A Multicenter, Cross-Cultural Study of Patients Referred for Outpatient Assessment

  • Christina D. Kay,
  • Ana Sofia Costa,
  • Tracy D. Vannorsdall,
  • Paula Aduen and ,
  • Clara Vila-Castelar,
  • Sarah M. Burstein,
  • Lauren Pollak,
  • Daniel K. Leibel,
  • Janet C. Sherman and
  • Yakeel T. Quiroz
  • + 7 authors+ 2 authors

2 September 2022

Objective: Cognitive dysfunction is one of the most frequently reported symptoms in post-acute sequelae of COVID-19 (PASC) and has become a common reason for neuropsychological referral. While data are emerging, we aimed to address possible cross-cul...

(This article belongs to the Special Issue How COVID-19 and Long COVID Changed Individuals and Communities)
  • Article
  • Open Access
11 Citations
5,865 Views
15 Pages

21 January 2024

Background: Antimicrobial resistance (AMR), a major global public health threat that has caused 1.2 million deaths, calls for immediate action. Antimicrobial stewardship (AMS) promotes judicious antibiotic use, but the COVID-19 pandemic increased AMR...

  • Article
  • Open Access
11 Citations
35,007 Views
12 Pages

26 September 2021

Viruses are the most common causative agents of inflammation in the oral cavity and throat region. Most respiratory tract infections are self-limiting and require no specific treatment. However, patients often use different self-medication therapies...

(This article belongs to the Topic Broad-Spectrum Antiviral Agents)
  • Article
  • Open Access
11 Citations
6,777 Views
13 Pages

Impacts of the COVID-19 Pandemic on Children and Families from Marginalized Groups: A Qualitative Study in Kingston, Ontario

  • Hannah Lee,
  • Imaan Bayoumi,
  • Autumn Watson,
  • Colleen M. Davison and ,
  • Minnie Fu,
  • Dionne Nolan,
  • Dan Mitchell,
  • Sheldon Traviss,
  • Jennifer Kehoe and
  • Eva Purkey
  • + 5 authors+ 0 author

30 November 2021

The COVID-19 pandemic has been associated with unprecedented changes to societal structure. School closures, unstable employment, and inaccessible health services have caused enormous disruptions to child and family wellbeing. This study identifies m...

  • Review
  • Open Access
10 Citations
6,231 Views
14 Pages

COVID-19 and Chronic Kidney Disease: A Narrative Review

  • Marília Paiva Martins and
  • Rodrigo Bueno de Oliveira

31 July 2023

The coronavirus disease-2019 (COVID-19) pandemic has had a profound impact on the world, causing loss of life, economic damage, and social disruption. Individuals with chronic kidney disease (CKD) are prone to complications and increased mortality re...

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