Design, Synthesis and Pharmacological Evaluation of Novel Small Molecule Leads: From Anti-Infective to Anti-Inflammatory Therapies
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioorganic Chemistry and Medicinal Chemistry".
Deadline for manuscript submissions: 30 August 2026 | Viewed by 164
Special Issue Editors
Interests: chemical development (synthesis, structural analysis) of new heterocyclic molecules with antimicrobial; anticancer; anti-inflammatory; antioxidant potential
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; drug design; organic synthesis; heterocyclic compounds; biological activity; SAR; ADME; lipophilicity; PCA; K-means clustering; peptide chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The Special Issue "Design, Synthesis and Pharmacological Evaluation of Novel Small Molecule Leads: From Anti-Infective to Anti-Inflammatory Therapies" highlights recent advances in the discovery and optimization of small-molecule compounds targeting a wide range of infectious and inflammatory pathologies. It brings together original research and reviews focused on the rational design, synthetic methodologies, structure–activity relationship (SAR) studies, and preclinical evaluation of novel chemical entities.
The contributions within this Special Issue will investigate how molecular architecture and structural modifications can influence biological activity, selectivity, and pharmacokinetic profiles, spanning antiparasitic, antiviral, antibacterial, antifungal, and anti-inflammatory mechanisms. Featured studies provide new insights into molecular modeling, chemical structure–biological activity relationships, target validation, and improved synthesis strategies enabling the discovery of potent and selective lead compounds.
Special emphasis is placed on interdisciplinary approaches integrating medicinal chemistry, computational modeling, and biological assays to accelerate lead identification and candidate optimization.
By providing new insights into chemical innovation and therapeutic potential, this Special Issue will inspire the development of safe and effective small-molecule therapeutics for the treatment and prevention of infectious and inflammatory diseases that remain serious global health challenges.
Dr. Anca Stana
Dr. Ioana Ionuț
Guest Editors
Manuscript Submission Information
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Keywords
- drug design
- pharmacological evaluation
- antimicrobial resistance
- infectious and inflammatory diseases
- target validation
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