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Current Issues in Molecular Biology publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Genetics and Epigenetics of Neurodegenerative Diseases

edited by

Salvatore Saccone

submission deadline 15 May 2026 | 2 articles | Viewed by 6056 | Submission Open

Keywords: genetics; neurodegenerative diseases; Alzheimer disease

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Natural Phytochemicals as Modulators of Cellular Pathways and Therapeutic Targets in Disease Models

edited by

Jui-Hung Yen

submission deadline 20 May 2026 | 2 articles | Viewed by 8199 | Submission Open

Keywords: phytochemicals; cellular signaling pathways; disease models; therapeutic targets; synergistic effects; natural products; bioactive modulators

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Biomaterials for Disease Diagnosis and Therapy: Emerging Molecular Innovations and Applications

edited by Md Tipu Sultan

submission deadline 20 May 2026 | Viewed by 310 | Submission Open

Keywords: biomaterials; disease diagnosis; nanoparticles; hydrogels; scaffolds; bio 3D printing; bioink; biosensors; drug delivery; tissue engineering; biocompatibility; translational medicine; cancer; neurodegenerative disorders; disease model; 3D-printed microfluidic devices; organ on a chip; 3D-printed medical devices

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Biomarker Discovery in Neurodegenerative Disorders

edited by

George P. Paraskevas

submission deadline 30 May 2026 | Viewed by 338 | Submission Open

Keywords: neurodegenerative diseases; molecular biomarkers; cerebrospinal fluid (CSF) biomarkers; positron emission tomography (PET); seeding amplification assay (SAA); plasma biomarkers

(This special issue belongs to the Section Molecular Medicine)

Cardiovascular Disease: From Molecular Mechanisms to Therapeutic Innovations

edited by Andrea Marzullo

submission deadline 31 May 2026 | 9 articles | Viewed by 16791 | Submission Open

Keywords: cardiovascular pathophysiology; molecular biomarkers; inflammation and oxidative stress; therapeutic targets; lipid metabolism

(This special issue belongs to the Section Molecular Medicine)

Advances in Molecular Therapies and Disease Associations in Diabetes

edited by

Hongbao Cao

and Shaolei Teng

submission deadline 31 May 2026 | 5 articles | Viewed by 11632 | Submission Open

Keywords: diabetes; molecular therapies; comorbidities; genomics; proteomics; metabolomics; multi-omics; precision medicine

(This special issue belongs to the Section Molecular Medicine)

Multiple Myeloma: From Molecular Mechanism to Diagnosis and Therapy

edited by

Jari Intra

submission deadline 31 May 2026 | 5 articles | Viewed by 9625 | Submission Open

Keywords: multiple myeloma; blood cancer; immunopathogenesis; biomarker; immunoglobulin

(This special issue belongs to the Section Molecular Medicine)

Advances in Phytochemical Research: Molecular Pathways in Health and Disease

edited by

Christiana Charalambous

and

Christiana Neophytou

submission deadline 31 May 2026 | 7 articles | Viewed by 7042 | Submission Open

Keywords: phytochemicals; molecular mechanisms; cancer signaling pathways; anti-inflammatory properties; anti-oxidant properties; apoptosis; cardiovascular disorders; metabolic syndromes; chemoprevention

(This special issue belongs to the Section Molecular Medicine)

The Molecular Basis of Immunotherapy in Cancer Treatment

edited by Hassan Dastsooz

submission deadline 31 May 2026 | 2 articles | Viewed by 6931 | Submission Open

Keywords: immunotherapy; cancer; CAR-T cell therapy; monoclonal antibodies; immunomodulation; cytokines; immune evasion mechanisms

(This special issue belongs to the Section Molecular Medicine)

Linking Genomic Changes with Cancer in the NGS Era, 3rd Edition

edited by Javier Azúa-Romeo

submission deadline 31 May 2026 | 8 articles | Viewed by 5883 | Submission Open

Keywords: next-generation sequencing (NGS); genetic variation; driver gene; functional validation; gene editing; cancer

(This special issue belongs to the Section Bioinformatics and Systems Biology)

Novel Pharmacological Strategies and Molecular Mechanisms in Nonclinical Research

edited by

Vanessa Mateus

submission deadline 31 May 2026 | 5 articles | Viewed by 4023 | Submission Open

Keywords: molecular pharmacology; drug targets; signal transduction pathways; nonclinical models; receptor-ligand interactions; pharmacogenomics; preclinical drug development; gene expression modulation; mechanism of action; translational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Advanced Research in Glioblastoma and Neuroblastoma

edited by

Maria G. Bottone

submission deadline 31 May 2026 | 2 articles | Viewed by 3454 | Submission Open

Keywords: glioblastoma; neuroblastoma; neuropharmaceuticals; drug design; blood– brain barrier; molecular therapeutics; brain-tumor biomarkers

(This special issue belongs to the Section Molecular Medicine)

Neuropituitary Hormones in Metabolic Disorders

edited by

Claudia Camerino

submission deadline 31 May 2026 | 2 articles | Viewed by 2687 | Submission Open

Keywords: oxytocin; vasopressin; thermoregulation; obesity; Prader– Willi syndrome; autism spectrum disorder; anorexia nervosa; craniopharyngioma; metabolic disorders; hypothalamic pituitary disorders; oxytocin-deficiency; vasopressin-deficiency

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Mechanisms and Pharmacological Underlying Cardiorenal Diseases

edited by

Caterina Carollo

submission deadline 31 May 2026 | 3 articles | Viewed by 2169 | Submission Open

Keywords: hypertension; cardio-renal syndromes; heart failure; chronic kidney disease; hemodialysis; periotenal dialysis

(This special issue belongs to the Section Molecular Medicine)

Repurposing and Innovation: Drug Research in Neuroprotection

edited by

Stela Dragomanova

submission deadline 31 May 2026 | 2 articles | Viewed by 1988 | Submission Open

Keywords: neuroprotection; drug repurposing; natural-derived compounds; neurodegenerative diseases; pharmacological innovation

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Plant Stress Responses and Development

edited by

Abdul Wakeel Umar

submission deadline 31 May 2026 | 3 articles | Viewed by 1525 | Submission Open

Keywords: plant stress physiology; hormonal signaling networks; abiotic stress tolerance; transcriptional regulation; epigenetics and chromatin dynamics; multi-omics integration; secondary metabolite biosynthesis; developmental plasticity; signal transduction; ROS and redox regulation; synthetic biology; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Vascular Biology in Health and Diseases

edited by

Nilanjana Maulik

submission deadline 31 May 2026 | 3 articles | Viewed by 1483 | Submission Open

Keywords: vascular biology; vascular disease; endothelium; cardiovascular disease (CVD); pathological mechanisms

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Cancer Genetics and Pharmacology: Advancing Precision Therapeutics

edited by Baoming Wang

submission deadline 31 May 2026 | 1 articles | Viewed by 1287 | Submission Open

Keywords: cancer genetics; epigenetic modifications; pharmacogenomics; personalized medicine

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Gene Expression and Regulation in Cancer

edited by

Karolina Bajdak-Rusinek

submission deadline 31 May 2026 | 1 articles | Viewed by 1164 | Submission Open

Keywords: cancer gene expression; oncogenic regulatory mechanisms; gene regulation targeted therapy; tumor phenotypes; cancer diagnostics and treatment

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights and Unique Characteristics in Adolescent and Young Adult Oncology

edited by

Antonio Ruggiero

submission deadline 31 May 2026 | 1 articles | Viewed by 1030 | Submission Open

Keywords: adolescent; young adult; biology; treatment; outcome

(This special issue belongs to the Section Molecular Medicine)

Natural Products in Health and Disease: Mechanisms, Therapeutic Applications, and Emerging Challenges

edited by

Hee-Geun Jo

submission deadline 31 May 2026 | 1 articles | Viewed by 787 | Submission Open

Keywords: herbal medicine; network pharmacology; multi-omics; microbiome; synergistic effects; multi-target; drug discovery; natural products

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular and Cellular Insights into the Musculoskeletal System, Joints and Spine

edited by Seon-Jin Yoon

submission deadline 31 May 2026 | 2 articles | Viewed by 769 | Submission Open

Keywords: musculoskeletal system; joints; spine; pain-related nerve system; genetics; sequencing; human; animal; cell

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Epithelial Cancers: From Molecular Mechanisms to Therapeutic Innovations

edited by

Cristian Scheau

and

Ana Caruntu

submission deadline 31 May 2026 | 1 articles | Viewed by 636 | Submission Open

Keywords: epithelial cancers human malignancies; tumor microenvironment; genetic alterations; epithelial– mesenchymal transition

(This special issue belongs to the Section Molecular Medicine)

Phytochemical-Based Therapeutics: Emerging Mechanisms and Biomedical Applications

edited by

Yoon-Jin Lee

submission deadline 31 May 2026 | 1 articles | Viewed by 622 | Submission Open

Keywords: phytochemicals; therapeutic mechanisms; natural products; signal transduction; bioactivity; drug delivery; translational research; biomedical applications

(This special issue belongs to the Section Molecular Medicine)

Molecular Regulation of Insect Adaptation

edited by

Lianxi Xing

submission deadline 31 May 2026 | 1 articles | Viewed by 591 | Submission Open

Keywords: insect adaptation; molecular regulation; cross-scale phenotyping; gene networks; phenotypic plasticity; ecological genomics; physiological mechanisms; epigenetics

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advances in piRNA Biology and Processing: Mechanisms and Applications

edited by

Yicheng Luo

submission deadline 31 May 2026 | Viewed by 494 | Submission Open

Keywords: piRNA; Piwi; transposable elements; epigenetics; genetics; development; cancer

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Medicinal Plants and Phytochemicals for the Prevention and Intervention of Metabolic Disease and Its Complications

edited by

Sandra Barbalho

submission deadline 31 May 2026 | Viewed by 406 | Submission Open

Keywords: metabolic diseases; phytochemicals; medicinal plants; metabolic diseases complications; functional foods

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Perspectives on the Development, Physiological Functions, and Reproduction of Aquatic Organisms

edited by

Mingzhe Yuan

submission deadline 31 May 2026 | Viewed by 282 | Submission Open

Keywords: molecular toxicology; environmental stressors; gene expression regulation; aquatic organism adaptation; epigenetic responses

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Advancements in Biomedical Optics and Brain Metabolism

edited by Jennifer M. Lynch

submission deadline 31 May 2026 | Viewed by 238 | Submission Open

Keywords: biomedical optics; brain metabolism; optical neuroimaging; cerebral blood flow; near-infrared spectroscopy; diffuse correlation spectroscopy; neurocritical care; noninvasive monitoring; optical biomarkers; brain health

(This special issue belongs to the Section Molecular Medicine)

Natural Polyphenols in Cardiovascular Disease Prevention: Molecular Mechanisms and Therapeutic Perspectives

edited by

Pasquale Perrone

submission deadline 31 May 2026 | Viewed by 216 | Submission Open

Keywords: polyphenols; phytochemicals; cardiovascular diseases; cardiovascular; protective

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Extracellular Proteostasis and Chaperone Networks in Neurodegeneration

edited by

Nicholas J. Geraghty

submission deadline 31 May 2026 | Viewed by 185 | Submission Open

Keywords: protein aggregation; extracellular chaperone; receptor-mediated endocytosis; protein clearance; neuronal stress response; protein trafficking; clusterin; haptoglobin; α 2-macroglobulin

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Approaches and Innovations for Human and Veterinary Vaccines

edited by Attila Farsang

submission deadline 31 May 2026 | Viewed by 173 | Submission Open

Keywords: vaccines; vaccinology; immunology mechanisms; vaccine vectors; gene vaccines; infection; host– pathogen interactions and responses

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Nanomedicines in Cancers Targeting and Therapy

edited by

Wei Jiang

submission deadline 31 May 2026 | Viewed by 161 | Submission Open

Keywords: nanomedicine; tumor targeting; cancer therapy; drug delivery vehicle; biomedical

(This special issue belongs to the Section Molecular Medicine)

Targeted Therapies and Biomarker Discovery in Health and Disease

edited by

Rodrigo Pinheiro Araldi

submission deadline 10 Jun 2026 | 2 articles | Viewed by 1575 | Submission Open

Keywords: multi-omics technologies; targeted therapies; biomarkers; oncology; neurology

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Insights: Mechanisms Underlying the Biological Activities of Natural Products—2nd Edition

edited by

Premalatha Balachandran

submission deadline 20 Jun 2026 | 9 articles | Viewed by 11031 | Submission Open

Keywords: natural products; molecular mechanisms; biological activities; pharmacodynamics; drug discovery; therapeutic potential; signaling pathways; target identification; pharmacological properties; bioactive compounds

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

The Green Revolution in Cancer Research: Bioactive Substances from Plants as Promising Therapeutics

edited by Johura Ansary

submission deadline 20 Jun 2026 | 5 articles | Viewed by 8333 | Submission Open

Keywords: bioactive compound; cancer research; plant-derived; anti-cancer properties; therapeutic strategies

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Advancements in Dendrimer Technology: From Molecular Biology Applications to Therapeutic Innovations

edited by

Jørn Bolstad Christensen

submission deadline 20 Jun 2026 | Viewed by 227 | Submission Open

Keywords: dendrimers; molecular biology applications; therapeutic innovations; nanomedicine; drug delivery

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Insights into Cancer Biomarkers: Identification and Practical Applications

edited by

Mihaela Chivu-Economescu

submission deadline 30 Jun 2026 | 7 articles | Viewed by 14317 | Submission Open

Keywords: cancer biomarkers; liquid biopsy; early detection; progression; prognosis; treatment monitoring

(This special issue belongs to the Section Molecular Medicine)

Advances in Molecular Biology Methods in Hepatology Research, 2nd Edition

edited by

Ralf Weiskirchen

and

Dileep G. Nair

submission deadline 30 Jun 2026 | 3 articles | Viewed by 8066 | Submission Open

Keywords: hepatic diseases; molecular biology methods; single-cell genomics; single-cell proteomics; hepatic organoids; biomarkers

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanism and Regulation in Neuroinflammation, 2nd Edition

edited by Hung-Pei Tsai

submission deadline 30 Jun 2026 | 2 articles | Viewed by 7902 | Submission Open

Keywords: microglia; glial cells; cytokines; blood– brain barrier; traumatic brain injury; aging; Alzheimer's disease; parkinson's disease; amyotrophic lateral sclerosis; multiple sclerosis

(This special issue belongs to the Section Molecular Medicine)

Molecular Functions of Long Non-Coding RNAs: Implications for Diseases and Therapy

edited by

Bodhisattwa Banerjee

submission deadline 30 Jun 2026 | 7 articles | Viewed by 7488 | Submission Open

Keywords: long non-coding RNAs (lncRNAs); gene regulation; molecular mechanisms; chromatin remodeling; epigenetic control; disease pathophysiology; biomarker discovery; therapeutic strategies; translational research

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

Molecular Breeding and Genetics Research in Plants—3rd Edition

edited by

Shimeles Tilahun

submission deadline 30 Jun 2026 | 9 articles | Viewed by 7389 | Submission Open

Keywords: genetic basis; genomic selection/prediction; molecular breeding; biotic and abiotic stresses; qPCR

(This special issue belongs to the Section Molecular Plant Sciences)

Tumor Immunology: From Molecular Mechanisms to Treatment

edited by

Deepika Awasthi

submission deadline 30 Jun 2026 | 2 articles | Viewed by 4190 | Submission Open

Keywords: cellular metabolism; metabolic reprogramming; immunometabolism; tumor microenvironment; immunotherapy; metabolites; immunosuppression; immune cells; tumor cells

(This special issue belongs to the Section Molecular Medicine)

Cancer Immunology: Molecular Tools, New Therapeutic Targets, Challenges, and Opportunities

edited by Pablo C. Ortiz-Lazareno

submission deadline 30 Jun 2026 | 4 articles | Viewed by 3039 | Submission Open

Keywords: cancer immunology; immune response; immune evasion; immune checkpoints; immune response

(This special issue belongs to the Section Molecular Medicine)

Natural Products in Biomedicine and Pharmacotherapy, 2nd Edition

edited by

Ahmed Ezat El Zowalaty

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2367 | Submission Open

Keywords: natural products; genetic engineering; pharmacotherapy; anticancer; antimicrobials

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Molecular Biology in Drug Design and Precision Therapy, 2nd Edition

edited by

Cristina Manuela Dragoi

Ion-Bogdan Dumitrescu

and

Alina Crenguta Nicolae

submission deadline 30 Jun 2026 | 3 articles | Viewed by 1591 | Submission Open

Keywords: molecular biology; drug design; molecular targets; disease mechanisms; structural biology; computational chemistry; pharmacology; precision medicine; molecular pathways; personalized therapy; drug research

(This special issue belongs to the Section Molecular Medicine)

Molecular Mechanisms, Diet and Therapeutic Interventions in Neurological Disorders

edited by

Giulia Accardi

and

Francesco Cacciabaudo

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1316 | Submission Open

Keywords: neurodegeneration; metabolic interventions; intermittent fasting; Mediterranean diet; molecular biomarkers; neuroinflammation; mitochondrial dysfunction; precision nutrition

(This special issue belongs to the Section Molecular Medicine)

Future Challenges of Targeted Therapy of Cancers, 3rd Edition

edited by

Simona Gurzu

submission deadline 30 Jun 2026 | 2 articles | Viewed by 1266 | Submission Open

Keywords: biomarkers; tumor tissue; individualized therapy; gene profile; epithelial– mesenchymal transition; immunotherapy; angiogenesis; metastases; oncology; pathology

(This special issue belongs to the Section Molecular Medicine)

Design and Synthesis of Bioactive Peptides and Molecular Conjugates for Targeted Drug Delivery

edited by

Ashmeet Singh

submission deadline 30 Jun 2026 | 1 articles | Viewed by 881 | Submission Open

Keywords: peptides; non-covalent synthesis; fluorescent probes; biomaterials; stimuli-responsive; hydrogels; site specific; drug delivery

(This special issue belongs to the Section Bioorganic Chemistry and Medicinal Chemistry)

Advances in Bioactive Molecules and Modern Structure–Activity Approaches

edited by

Claudiu N. Lungu

submission deadline 30 Jun 2026 | 1 articles | Viewed by 834 | Submission Open

Keywords: QSAR; structure– activity modeling; drug design

(This special issue belongs to the Section Biochemistry, Molecular and Cellular Biology)

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