Novel Pharmacological Strategies and Molecular Mechanisms in Nonclinical Research
A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 13
Special Issue Editor
2. Laboratory of Systems Integration Pharmacology, Clinical & Regulatory Science, Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Av. Prof Gama Pinto, 1649-003 Lisboa, Portugal
3. H&TRC—Health and Technology Research Center, ESTeSL—Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa, 1990-096 Lisboa, Portugal
Interests: pharmacology; pharmacotherapy; non-clinical studies; disease animal models; inflammation; inflammatory bowel disease; colitis-associated cancer; periodontitis
Special Issue Information
Dear Colleagues,
The Special Issue "Novel Pharmacological Strategies and Molecular Mechanisms in Nonclinical Research" aims to explore innovative advances in pharmacology, focusing on the molecular underpinnings that drive drug efficacy and safety in nonclinical models. As the complexity of disease biology becomes increasingly evident, the development of targeted pharmacological interventions requires an in-depth understanding of their molecular and cellular pathways. This Special Issue seeks to gather original research and systematic reviews on novel drug targets, signalling cascades, receptor–drug interactions, gene expression modulation, and molecular biomarkers predictive of therapeutic response.
Particular emphasis will be placed on studies employing in vivo models to uncover mechanistic insights into drug action. Contributions may also include innovative drug delivery approaches, pharmacological structure–activity relationships, and pharmacogenomic strategies. By bridging molecular mechanisms with pharmacological innovation, this Special Issue aims to provide a comprehensive overview of how molecular-level research can be integrated with preclinical development to guide the rational design of next-generation therapeutics, enhancing their translational potential.
Researchers from pharmacology, molecular biology, and related disciplines are invited to contribute to this Special Issue, which aims to promote interdisciplinary dialogue and accelerate the bench-to-bedside transition of novel pharmacological strategies.
Dr. Vanessa Mateus
Guest Editor
Manuscript Submission Information
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Keywords
- molecular pharmacology
- drug targets
- signal transduction pathways
- nonclinical models
- receptor-ligand interactions
- pharmacogenomics
- preclinical drug development
- gene expression modulation
- mechanism of action
- translational pharmacology
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