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Natural Products in Biomedicine and Pharmacotherapy, 2nd Edition

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Bioorganic Chemistry and Medicinal Chemistry".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 1249

Special Issue Editor


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Guest Editor
Institute of Clinical Sciences, Department of Surgery, Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg, Sweden
Interests: redox signaling; Keap1; Nrf2; liver cancer; lung cancer; apoptosis; DNA damage; cellular toxicology; genetic toxicology; gene regulation; cell physiology; xenobiotics; pharmacogenomics; toxicogenomics; carcinogenesis; endocrine disruptors; metabolism; mouse models; structure–activity relationships
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Special Issue Information

Dear Colleagues,

Bioactive compounds from natural products and their structural analogues have been used for a long time in biomedical and pharmacotherapeutic applications for treating conditions such as cancer, cardiovascular diseases, and infectious diseases. Following on from the first edition, we invite researchers to present primary research papers, reviews, visionary perspectives, or retrospective analyses that address recent advances in our understanding of the contributions of natural products to biological processes, as well as to the development of new therapeutics with consequences for human health and drug safety. Studies addressing the pharmacokinetic and pharmacodynamic properties of natural products, as well as studies utilizing novel analytical tools, the genome mining of novel natural products, the genetic engineering of natural products’ biosynthetic genes, structure-based methods, molecular dynamics simulations, and computational tools for the analysis of bioactive compounds from natural products, are welcome. Studies utilizing rational genetic engineering, promoter engineering, targeted gene manipulation, and heterologous expression for improving the pharmacological properties of bioactive compounds, as well as for improving the immunomodulatory properties of natural products, would also be an asset.

Dr. Ahmed Ezat El Zowalaty
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • genetic engineering
  • pharmacotherapy
  • anticancer
  • antimicrobials

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Published Papers (1 paper)

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Review

36 pages, 1849 KB  
Review
Mechanistic Insights into the Wound Healing Activity of Plant Species in Diabetic Ulcers
by Rodson Glauber Ribeiro Chaves, Fernanda Farias Costa, Letícia Andrade Fuchs, Lays Scherrer Rodrigues, Rhuan Antonio Nogueira Moraes, Paulo Sila da Silva Alves Junior, Márcia Cristina Goncalves Maciel, Flavia Maria Mendonça Amaral, Denise Fernandes Coutinho and Aramys Silva Reis
Curr. Issues Mol. Biol. 2025, 47(12), 972; https://doi.org/10.3390/cimb47120972 - 24 Nov 2025
Viewed by 859
Abstract
Diabetic foot ulcers represent a major complication driven by chronic inflammation, oxidative stress, impaired angiogenesis, and defective extracellular matrix remodeling. This integrative review synthesizes mechanistic evidence from 51 preclinical studies evaluating plant-derived interventions in diabetic animal models. Database searches (PubMed, Embase, Scopus) identified [...] Read more.
Diabetic foot ulcers represent a major complication driven by chronic inflammation, oxidative stress, impaired angiogenesis, and defective extracellular matrix remodeling. This integrative review synthesizes mechanistic evidence from 51 preclinical studies evaluating plant-derived interventions in diabetic animal models. Database searches (PubMed, Embase, Scopus) identified species modulating discrete molecular targets across healing phases. In the inflammatory phase, extracts suppressed NF-κB-dependent cytokine production (IL-1β, TNF-α, IL-6), reduced oxidative stress via Nrf2/HO-1 activation, and disrupted AGE-RAGE signaling, facilitating neutrophil resolution and macrophage reprogramming. During proliferation, interventions upregulated angiogenic factors (VEGF, bFGF, IGF-1) through ERK1/2 and PI3K/Akt-eNOS pathways, stimulated fibroblast proliferation, and enhanced collagen deposition. In the remodeling phase, extracts improved tensile strength by modulating MMP-2/9 and TIMP-2 balance, promoting type I collagen maturation and organized fiber architecture. Polyphenol-rich species (Punica granatum, Quercus infectoria, Polygonatum kingianum) demonstrated the most robust multi-target activity. However, translational gaps persist due to extract heterogeneity, limited phytochemical standardization, and overreliance on young male rodent models. Future development requires standardized bioactive quantification, dose–response characterization, advanced delivery systems (hydrogels, nanofibers), and validation in aged animals with comorbidities. These mechanistic insights support plant-based therapies as multi-component adjuvants targeting the complex pathophysiology of diabetic ulcers. Full article
(This article belongs to the Special Issue Natural Products in Biomedicine and Pharmacotherapy, 2nd Edition)
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