Recent Developments in Cellular and Molecular Mechanisms and Therapeutic Approaches to Cardiovascular and Metabolic Diseases

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 30 July 2025 | Viewed by 854

Special Issue Editor


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Guest Editor
Department Woman-Mother-Child, Division of Pediatrics, DOHaD Laboratory, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland
Interests: endothelial colony-forming cells; oxidative stress; stress-induced premature senescence; cardiometabolic disorders

Special Issue Information

Dear Colleagues,

Cardiovascular and metabolic diseases are increasing globally, posing a significant public health challenge. It is now well established that these chronic conditions are influenced not only by lifestyle factors in adulthood but also by early-life events, particularly during the first 1,000 days of life. Given the multifaceted nature of these diseases, which affect multiple organs and systems, recent research has focused on identifying key factors and mechanisms contributing to the development of cardiometabolic disorders. These include genetic and epigenetic influences, sex hormones, microbiota composition, inflammation, oxidative stress, programmed cell death, circadian rhythm disruptions, and environmental exposures. The aim of all these studies is to inform and develop targeted therapeutic approaches, such as cardiovascular treatments, oxidative stress management, nutritional interventions, cell therapies, and hormone replacement strategies.

In addition, cardiometabolic disorders exhibit differences based on gender. Women tend to have greater protection against these diseases compared to men, at least until menopause. Furthermore, the underlying mechanisms and potential therapeutic strategies may be significantly influenced by sexual dimorphism, underscoring the importance of incorporating gender-specific considerations into both research and treatment.

Dr. Catherine Yzydorczyk
Guest Editor

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Keywords

  • cardiometabolic diseases
  • developmental programming
  • sexual dimorphism

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Published Papers (1 paper)

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Review

68 pages, 19995 KiB  
Review
Sexual Dimorphism in Cardiometabolic Diseases: From Development to Senescence and Therapeutic Approaches
by Thea Chevalley, Marion Dübi, Laurent Fumeaux, Maria Serena Merli, Alexandre Sarre, Natacha Schaer, Umberto Simeoni and Catherine Yzydorczyk
Cells 2025, 14(6), 467; https://doi.org/10.3390/cells14060467 - 20 Mar 2025
Viewed by 748
Abstract
The global incidence and prevalence of cardiometabolic disorders have risen significantly in recent years. Although lifestyle choices in adulthood play a crucial role in the development of these conditions, it is well established that events occurring early in life can have an important [...] Read more.
The global incidence and prevalence of cardiometabolic disorders have risen significantly in recent years. Although lifestyle choices in adulthood play a crucial role in the development of these conditions, it is well established that events occurring early in life can have an important effect. Recent research on cardiometabolic diseases has highlighted the influence of sexual dimorphism on risk factors, underlying mechanisms, and response to therapies. In this narrative review, we summarize the current understanding of sexual dimorphism in cardiovascular and metabolic diseases in the general population and within the framework of the Developmental Origins of Health and Disease (DOHaD) concept. We explore key risk factors and mechanisms, including the influence of genetic and epigenetic factors, placental and embryonic development, maternal nutrition, sex hormones, energy metabolism, microbiota, oxidative stress, cell death, inflammation, endothelial dysfunction, circadian rhythm, and lifestyle factors. Finally, we discuss some of the main therapeutic approaches, responses to which may be influenced by sexual dimorphism, such as antihypertensive and cardiovascular treatments, oxidative stress management, nutrition, cell therapies, and hormone replacement therapy. Full article
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