Recent Developments in Cellular and Molecular Mechanisms and Therapeutic Approaches to Cardiovascular and Metabolic Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: closed (30 July 2025) | Viewed by 2745
Special Issue Editor
Interests: endothelial colony-forming cells; oxidative stress; stress-induced premature senescence; cardiometabolic disorders
Special Issue Information
Dear Colleagues,
Cardiovascular and metabolic diseases are increasing globally, posing a significant public health challenge. It is now well established that these chronic conditions are influenced not only by lifestyle factors in adulthood but also by early-life events, particularly during the first 1,000 days of life. Given the multifaceted nature of these diseases, which affect multiple organs and systems, recent research has focused on identifying key factors and mechanisms contributing to the development of cardiometabolic disorders. These include genetic and epigenetic influences, sex hormones, microbiota composition, inflammation, oxidative stress, programmed cell death, circadian rhythm disruptions, and environmental exposures. The aim of all these studies is to inform and develop targeted therapeutic approaches, such as cardiovascular treatments, oxidative stress management, nutritional interventions, cell therapies, and hormone replacement strategies.
In addition, cardiometabolic disorders exhibit differences based on gender. Women tend to have greater protection against these diseases compared to men, at least until menopause. Furthermore, the underlying mechanisms and potential therapeutic strategies may be significantly influenced by sexual dimorphism, underscoring the importance of incorporating gender-specific considerations into both research and treatment.
Dr. Catherine Yzydorczyk
Guest Editor
Manuscript Submission Information
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Keywords
- cardiometabolic diseases
- developmental programming
- sexual dimorphism
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