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Cells
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Advances in the Regulation of Proteins and Genes for Stem...
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Advances in the Regulation of Proteins and Genes for Stem Cells

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".

Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 569

Special Issue Editor

Prof. Dr. Bonghee Lee

E-Mail Website
Guest Editor
Center for Genomics and Proteomics & Stem Cell Core Facility, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea
Interests: stem cells; biomarkers; genomics; proteomics; therapeutics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advancements in genomics and proteomics have significantly enhanced our understanding of stem cell biology, offering insights into their fundamental properties and potential therapeutic applications.

Genomics involves the comprehensive analysis of an organism’s complete set of DNA, including all of its genes. In stem cell research, genomics has been instrumental in identifying pluripotency markers, understanding differentiation pathways, and ensuring genomic integrity.

Proteomics is the large-scale study of proteins, which are vital to understanding cellular functions. In the context of stem cells, proteomics has facilitated the elucidation of differentiation mechanisms, the identification of post-translational modifications (PTMs), and the development of diagnostic tools.

The convergence of genomics and proteomics in stem cell research has deepened our understanding of stem cell biology, improved the development of differentiation protocols, and enhanced the safety and efficacy of stem cell-based therapies.

Therefore, this Special Issue will summarize the latest genomic and proteomic findings involved in stem cells, both in maintenance and differentiation. The use of genomic and proteomic biomarkers as potential diagnostic markers and therapeutics for the prevention or treatment of intractable diseases will also be addressed.

I look forward to your contributions.

Prof. Dr. Bonghee Lee
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stem cells
  • pluripotency
  • differentiation
  • diagnosis
  • therapeutics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

15 pages, 6702 KiB  
Article
CREB5 Promotes the Proliferation of Neural Stem/Progenitor Cells in the Rat Subventricular Zone via the Regulation of NFIX Expression
by Tao Yu, Hanyue Zhang, Chuang Zhang, Guorui Ma, Tu Shen, Yan Luan and Zhichao Zhang
Cells 2025, 14(16), 1240; https://doi.org/10.3390/cells14161240 - 12 Aug 2025
Viewed by 374
Abstract
Neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) of the central nervous system (CNS) are critical for tissue repair following injury or disease. These cells retain the capacity to proliferate, migrate, and differentiate into neurons, astrocytes, and oligodendrocytes, making them a promising [...] Read more.
Neural stem/progenitor cells (NSPCs) in the subventricular zone (SVZ) of the central nervous system (CNS) are critical for tissue repair following injury or disease. These cells retain the capacity to proliferate, migrate, and differentiate into neurons, astrocytes, and oligodendrocytes, making them a promising therapeutic target for neurodegenerative disorders and traumatic injuries. However, the molecular mechanisms regulating their proliferation remain incompletely understood. This study investigates the role of cAMP responsive element-binding protein 5 (CREB5) in the proliferation of rat SVZ-derived NSPCs and elucidates its regulatory mechanism. Using RNA interference, we demonstrated that CREB5 knockdown significantly reduced cell viability, neurosphere formation capacity, and the number of proliferating cells (BrdU- and Ki-67-positive cells) both in vitro and in vivo. In contrast, CREB5 overexpression played opposing roles in cell proliferation. Additionally, alteration of CREB5 expression did not affect apoptosis, as assessed by TUNEL staining, indicating a specific role in proliferation rather than in cell death. Mechanistically, we identified Nuclear Factor One X (NFIX) as a transcriptional target of CREB5. CREB5 binds to the AP-1 site in the NFIX promoter, enhancing its expression. CREB5 knockdown inhibited NFIX expression, while CREB5 overexpression exerted the opposite function. ChIP and luciferase reporter assays further confirmed that CREB5 directly regulates NFIX promoter activity. More importantly, alteration of NFIX expression could reverse the effect of CREB5 on NSPC proliferation. These findings highlight CREB5 as a key regulator of NSPC proliferation through its interaction with NFIX, providing a potential therapeutic target for stem cell-based treatments of CNS disorders. Full article
(This article belongs to the Special Issue Advances in the Regulation of Proteins and Genes for Stem Cells)
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