New Research on Immunity and Inflammation in Cardiovascular Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Cardiovascular System".
Deadline for manuscript submissions: 31 July 2025 | Viewed by 580
Special Issue Editor
Interests: cardiovascular disease and inflammation; preclinical atherosclerosis; endothelial dysfunction; intima-media thickness
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The basic pathogenetic mechanisms of cardiovascular (CV) disease remain poorly understood. Recent evidence shows that immuno-inflammatory activity plays a pivotal role in many CV diseases. Atherosclerosis, as the most frequent cardiovascular disease, is primarily a chronic inflammatory disease of the arterial wall. Inflammation induces endothelial dysfunction, which results in an increased permeability of the vessel wall to lipoproteins and their sub-endothelial accumulation. It also induces leukocyte recruitment and platelet activation, which is followed by atherosclerotic plaque formation and CV events. Inflammation is a common mechanism that links traditional risk factors to the development of atherosclerosis. Inflammation is a critical feature of vulnerable plaques, which influences their stability and related thromboembolic complications. In addition, inflammatory pathways may be leading mechanisms in other CV diseases, including heart failure, cardiomyopathies, and rhythm disorders. Inflammation is also involved in the pathogenesis of venous thromboembolic diseases and chronic venous insufficiency. Inflammation of the vessel wall is specifically caused by a large family of chemotactic cytokines, known as chemokines. The intensity of inflammatory processes can be determined by establishing the levels of circulating inflammatory markers, which also serve as potential biomarkers of disease severity and prognosis.
In the proposed Special Issue, “New Research on Immunity and Inflammation in Cardiovascular Disease”, we would like to elucidate the role of inflammation in the pathogenesis of different atherosclerotic CV diseases and its involvement in venous diseases. In addition, the utility of circulating inflammatory markers in determining disease severity and prognosis will be discussed. Finally, the role of the anti-inflammatory treatment of CV disease will be described.
Prof. Dr. Pavel Poredoš
Guest Editor
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Keywords
- inflammation
- atherosclerosis
- coronary artery disease
- peripheral arterial disease
- cerebrovascular disease
- venous thromboembolic disease
- circulating biomarkers
- anti-innflammatory treatment of cardiovascular disease
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