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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Current Advances in Plant Gene Regulatory Networks

edited by

Laszlo Kozma-Bognar

submission deadline 20 Feb 2026 | 1 articles | Viewed by 911 | Submission Open

Keywords: plants; light signaling; circadian clock; thermomorphogenesis; hormonal regulation; a/biotic stress-responsive gene expression; flowering time

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Advances in Molecular Research on Cancer Drug Targets and Drug Resistance

edited by

Yuhao Xie

Concettina La Motta

and

Rakesh Kumar Srivastava

submission deadline 20 Feb 2026 | Viewed by 240 | Submission Open

Keywords: cancer therapy; drug targets; drug resistance; molecular mechanisms; targeted therapy; tumor microenvironment; personalized medicine; biomarkers

Molecular Cell Biology of T Cells in Cancer and Infectious Diseases

edited by

Gustavo P. Amarante-Mendes

and João Viola

submission deadline 20 Feb 2026 | Viewed by 149 | Submission Open

Keywords: T cells; cancer; infectious diseases; genomics; proteomics; metabolomics; metabolism

(This special issue belongs to the Section Cellular Immunology)

Elucidating Roles of Cell Adhesion Molecules in Health and Disease

edited by Vladimir Sytnyk

submission deadline 20 Feb 2026 | Viewed by 143 | Submission Open

Keywords: cell adhesion molecules (CAMs); immunoglobulin superfamily CAMs（IgSF-CAMs); integrins; cadherins; selectins; proteoglycans

Advances in T Cell Targeting for Cancer Immunotherapy

edited by Ryma Toumi

submission deadline 20 Feb 2026 | Viewed by 105 | Submission Open

Keywords: immunotherapy; immune checkpoint blockade; immunosuppressive microenvironment; exhaustion; armored T cells; adoptive cell therapy

Autophagic Signatures in Health and Disease: Molecular Insights and Clinical Applications

edited by

Simone Patergnani

and

Alberto Danese

submission deadline 20 Feb 2026 | Viewed by 72 | Submission Open

Keywords: autophagy; pathology; physiology; therapy; methods

(This special issue belongs to the Section Autophagy)

Astrocytes: Roles and Functions in the Brain

edited by

Victor Huang

and

Rita Raisman-Vozari

submission deadline 21 Feb 2026 | Viewed by 100 | Submission Open

Keywords: astrocyte biology; glial cells; synaptic regulation; CNS disorders; neuroinflammation; blood– brain barrier; brain metabolism; reactive astrocytes; neuron– glia interaction; therapeutic targeting

Natural Products and Their Derivatives Against Human Disease

edited by

Mamunur Rashid

submission deadline 25 Feb 2026 | 6 articles | Viewed by 10427 | Submission Open

Keywords: natural products; immunomodulatory; diseases; molecular mechanism of immunity

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Molecular and Signaling Pathways in Pathological Changes of Esophageal, Gastric and Intestinal Epithelial Cells and Methods of Cell Protective Treatment

edited by

Tomasz Brzozowski

submission deadline 25 Feb 2026 | 1 articles | Viewed by 774 | Submission Open

Keywords: gastrointestinal epithelial cells; cellular signaling; molecular pathways; cell damage; cell protection; esophageal integrity; gastric secretion; gastric ulcer; duodenal ulcer; intestinal digestion and absorption; intestinal integrity; inflammatory bowel disease; irritable bowel syndrome; ulcerative colitis; Crohn’ s disease

Small Molecule Inhibitors: A New Era in Cancer Treatment

edited by

Natarajan Aravindan

Kousalya Lavudi

and Suman Asalla

submission deadline 25 Feb 2026 | Viewed by 186 | Submission Open

Keywords: small-molecule inhibitors; CAR-T cell therapy; immune responsiveness; cancer cell resistance

Molecular, Cellular and Biochemical Approaches of Anti-Cancer Drugs

edited by

Gamaleldin Ibrahim Harisa

submission deadline 25 Feb 2026 | Viewed by 148 | Submission Open

Keywords: anti-cancer drugs; chemosensitizers; multidrug resistance; cellular techniques; nanoparticle delivery; in silico studies; in vivo studies; targeted therapies; cancer progression; bioactive compounds

Research on Extracellular Vesicles in Health and Disease

edited by

Maria Concetta Cufaro

submission deadline 25 Feb 2026 | Viewed by 145 | Submission Open

Keywords: extracellular vesicles; molecular mechanism; biomarker discovery; therapeutics; translational medicine; proteins; DNA and RNA

Molecular and Cellular Mechanisms of Ischemic Stroke

edited by Milani Deb-Chatterji

submission deadline 25 Feb 2026 | Viewed by 121 | Submission Open

Keywords: ischemic stroke; neuroinflammation; blood– brain barrier; neurovascular unit; molecular targets for stroke therapy

Remyelination: From Molecular Mechanism to Therapy

edited by

Antonella Ragnini-Wilson

and

Gaetano Barbato

submission deadline 25 Feb 2026 | Viewed by 119 | Submission Open

Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration

New Trends and Advances in Induced Neural Cells and iPSC Technologies

edited by

Guoqiang Sun

submission deadline 25 Feb 2026 | Viewed by 112 | Submission Open

Keywords: induced neural cells; induced pluripotent stem cell (iPSC); neurological disease modeling

(This special issue belongs to the Section Cells of the Nervous System)

Antigen Processing in Autoimmunity and Cancer—Mechanisms and Translational Perspectives

edited by Peter Van Endert

submission deadline 25 Feb 2026 | Viewed by 104 | Submission Open

Keywords: major histocompatibility molecule; antigen processing; antigen presentation; protease; endoplasmic reticulum aminopeptidase; antitumor immunity; autoimmunity; immunotherapy

Molecular Mechanisms of Treatment Resistance in Prostate Cancer

edited by

Christopher J. Ong

submission deadline 25 Feb 2026 | Viewed by 93 | Submission Open

Keywords: metastatic castration-resistant prostate cancer (mCRPC); molecular mechanisms; novel treatment strategies; systemic precision treatments; epigenetics; cellular plasticity; tumor microenvironment signaling; therapeutic resistance

The Role of the Extracellular Matrix in Tissue Development, Repair, and Disease

edited by

Stacey C. Schutte

Wei-Chih Lien

and

Ching-Yun Chen

submission deadline 26 Feb 2026 | Viewed by 76 | Submission Open

Keywords: extracellular matrix; matrisome; cell– ECM interactions; cell signaling

(This special issue belongs to the Section Tissues and Organs)

Mitophagy and Mitochondrial Quality Control in Neurodegenerative Disorders

edited by Mohamed Eldeeb

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1392 | Submission Open

Keywords: protein degradation; protein quality control; proteasome; ubiquitin; autophagy; mitophagy; mitochondrial quality control; mitochondrial import; proteolysis; neurodegeneration

(This special issue belongs to the Section Mitochondria)

Novel Insights into Mechanism and Treatment of Degenerative Disc Disease

edited by Yejia Zhang

submission deadline 27 Feb 2026 | 1 articles | Viewed by 1148 | Submission Open

Keywords: intervertebral disc (IVD) degeneration; back pain; age; genetics; injury

(This special issue belongs to the Section Cellular Pathology)

Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation

edited by Hari Krishna Reddy Rachamala and

Naga Malleswara Rao Nakka

submission deadline 27 Feb 2026 | 1 articles | Viewed by 372 | Submission Open

Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology

(This special issue belongs to the Section Cell Methods)

Targeting of Cancer Cells with Small Molecule Drugs

edited by

Jannet Kocerha

submission deadline 27 Feb 2026 | Viewed by 90 | Submission Open

Keywords: small molecule drugs; cancer cell targeting; targeted cancer therapy; drug delivery systems; precision oncology

(This special issue belongs to the Section Cellular Pathology)

Ion Channels in Cancer: From Molecular Mechanisms to Therapeutic Targets

edited by Saverio Gentile

submission deadline 27 Feb 2026 | Viewed by 81 | Submission Open

Keywords: ion channels; cancer therapeutic targeting; tumor microenvironment

Pathogenesis of Alcohol-Associated Hepatitis and Its Therapies

edited by Kyle Lauren Poulsen

submission deadline 27 Feb 2026 | Viewed by 77 | Submission Open

Keywords: alcohol-associated hepatitis; drug screening; drug delivery; pathophysiology; therapeutics

Signaling in Cancer Stem Cells

edited by Upasana Ray

submission deadline 28 Feb 2026 | 3 articles | Viewed by 12057 | Submission Open

Keywords: cancer stem cells (CSCs); stem cells signaling pathways; cancer progression and metastasis; therapeutic resistance; targeting cancer stem cells signaling; cancer heterogeneity; targeted therapy for CSCs; identifying biomarkers for CSCs

(This special issue belongs to the Section Stem Cells)

Role of Extracellular Matrix in Cancer and Disease

edited by

Maurizio Onisto

Marco Franchi

and

Valentina Masola

submission deadline 28 Feb 2026 | 6 articles | Viewed by 11299 | Submission Open

Keywords: extracellular matrix; cancer; disease; ECM targeting; ECM turn-over and remodeling

(This special issue belongs to the Section Cell Microenvironment)

The Role of IgE and IgG Antibodies in Allergic Reactions: Cellular Mechanisms and Biological Implications

edited by

Monique Vogel

and

Paul Engeroff

submission deadline 28 Feb 2026 | 3 articles | Viewed by 10466 | Submission Open

Keywords: IgE; IgG; allergy; inflammation; glycosylation; immunotherapy; autoantibodies; Fc receptors; soluble receptors

(This special issue belongs to the Section Cellular Immunology)

Cellular Pathology: Emerging Discoveries and Perspectives in the USA

edited by

Mohammed S. Razzaque

submission deadline 28 Feb 2026 | 2 articles | Viewed by 5900 | Submission Open

Keywords: cellular pathology; diseases; mechanisms

(This special issue belongs to the Section Cellular Pathology)

The Potential of Induced Pluripotent Stem Cells

edited by Yun Chang

submission deadline 28 Feb 2026 | 2 articles | Viewed by 5015 | Submission Open

Keywords: pluripotent stem cells; reprogramming; engineering; regenerative medicine; differentiation; therapeutic applications; biomaterials

(This special issue belongs to the Section Stem Cells)

Cell Migration and Invasion

edited by Veronika Miskolci

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3601 | Submission Open

Keywords: cell migration; cell invasion; cancer metastasis; molecular mechanisms; therapeutic strategies; signaling pathways

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 28 Feb 2026 | 3 articles | Viewed by 3203 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Biomarkers in Human Diseases and Emerging Diagnostic Technologies for Their Identification and Application

edited by

Andrea Cruz

and

Carla Carvalho

submission deadline 28 Feb 2026 | 2 articles | Viewed by 3164 | Submission Open

Keywords: biomarkers; human diseases; disease mechanisms; biomarker validation; early detection; accurate diagnosis; prognosis evaluation; treatment monitoring; diagnostic technologies; biosensors; microfluidics

Membrane Dynamics and the Role of Aquaporins in Plant Cells

edited by

Farzana Sabir

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2980 | Submission Open

Keywords: aquaporins; membrane dynamics; plant cell; water transport; osmoregulation; cell membrane permeability; aquaglyceroporins; stress response; membrane trafficking

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Skeletal Muscle: Structure, Physiology and Diseases

edited by

Vincenzo Sorrentino

submission deadline 28 Feb 2026 | 2 articles | Viewed by 2708 | Submission Open

Keywords: excitation– contraction coupling; store-operated calcium entry; sarcomeric proteins; skeletal muscle metabolism; skeletal muscle diseases; muscle plasticity; development; sarcopenia; aging

(This special issue belongs to the Section Tissues and Organs)

Cell Therapeutics for Corneal Diseases

edited by

Dimitrios Karamichos

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2201 | Submission Open

Keywords: cell therapies; corneal diseases; drug development; tissue engineering; stem cells; regeneration; tissue repair

(This special issue belongs to the Section Tissues and Organs)

Unconventional T Cells in Health and Disease

edited by Lauren Howson

submission deadline 28 Feb 2026 | 1 articles | Viewed by 2054 | Submission Open

Keywords: MR1-restricted T cells; γ δ T cells; CD1-restricted T cells; unconventional T cells

(This special issue belongs to the Section Cellular Immunology)

Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition

edited by

Qiwei Yang

submission deadline 28 Feb 2026 | 1 articles | Viewed by 1586 | Submission Open

Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome

(This special issue belongs to the Section Cellular Pathology)

Signal Transduction and Targeted Therapy for Tumors

edited by

Rodolfo Daniel Cervantes-Villagrana

submission deadline 28 Feb 2026 | Viewed by 1029 | Submission Open

Keywords: cancer progression; metastasis; invasion; cancer signaling; cell communication; cancer neuroscience; tumor angiogenesis; target therapy; immunotherapy; drug resistance; anti-tumor therapy

(This special issue belongs to the Section Cell Signaling)

Kidney Disease: The Role of Cellular Mechanisms in Renal Pathology

edited by

Jinu Kim

submission deadline 28 Feb 2026 | 1 articles | Viewed by 806 | Submission Open

Keywords: kidney fibrosis; acute kidney injury (AKI); chronic kidney disease (CKD); epithelial-to-mesenchymal transition (EMT); renal cell populations; stem cell therapy; renal regeneration; inflammation in kidney disease; cell-based models; renal repair mechanisms

(This special issue belongs to the Section Tissues and Organs)

The Pivotal Role of Tumor Stem Cells in Glioblastoma: Second Edition

edited by

Paola Palumbo

and Silvano J. Santini

submission deadline 28 Feb 2026 | 1 articles | Viewed by 802 | Submission Open

Keywords: glioblastoma stem cells; resistance; cancer therapy; signaling pathways; tumor microenvironment

Cellular Mechanisms in Oral Cavity Homeostasis and Disease

edited by

Mohamed Mekhemar

submission deadline 28 Feb 2026 | 1 articles | Viewed by 691 | Submission Open

Keywords: oral cavity; cell signaling; periodontal disease; stem cells; regeneration; inflammation; oral epithelium; tissue homeostasis; immunomodulation; cellular microenvironment

Role of RNA as Regulator, Therapeutic Target and Probe for Early Disease Diagnosis

edited by

Mona Batish

submission deadline 28 Feb 2026 | Viewed by 407 | Submission Open

Keywords: coding RNAs; non-coding RNAs (ncRNAs); regulatory RNAs; RNA-based diagnostics; disease biomarkers; RNA monitoring techniques; molecular probes; RNA interference (RNAi)

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 28 Feb 2026 | Viewed by 342 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

Novel Insights into Neuroinflammation and Related Diseases

edited by Tahmineh Mokhtari

submission deadline 28 Feb 2026 | Viewed by 318 | Submission Open

Keywords: neuroinflammation; neuropsychological disorders; neurodegeneration; neuro-immune interactions; glial-neuronal crosstalk; autophagy and apoptosis; cellular and molecular mechanisms; neuroinflammatory biomarkers; imaging techniques; novel therapeutic strategies

(This special issue belongs to the Section Cells of the Nervous System)

Parkinson's Disease: Advances in Molecular Understanding and Emerging Therapies

edited by

Asad Jan

and Sara Elfarrash

submission deadline 28 Feb 2026 | Viewed by 223 | Submission Open

Keywords: Parkinson’ s disease; atypical Parkinsonism; neurodegeneration; neuroinflammation; alpha-synuclein; disease models; brain organoids; human induced pluripotent stem cells (iPSCs); transcriptomics; proteomics; multi-omics; spatial biology; multiplex imaging; PD genetics

(This special issue belongs to the Section Cellular Aging)

Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms

edited by Tirthadipa Pradhan-Sundd

submission deadline 28 Feb 2026 | Viewed by 221 | Submission Open

Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells

Ocular Surface and Adnexal Diseases: Molecular Mechanisms and Treatment Progresses

edited by

Edit Tóth-Molnár

submission deadline 28 Feb 2026 | Viewed by 163 | Submission Open

Keywords: ocular surface and adnexal diseases; dry eye disease; eyelid diseases; lacrimal gland diseases; molecular mechanisms; therapeutic strategies

Recent Advances in Microfluidics and Organoids for Biomedical Applications

edited by Lionel Fernel Gamarra

submission deadline 28 Feb 2026 | Viewed by 161 | Submission Open

Keywords: microfluidics; organoids; biomimetic models; organ-on-a-chip; tissue engineering; pharmacology; biosensors; computational modeling; artificial intelligence; nanomedicine; personalized medicine; bioprinting; in silico; induced pluripotent stem cells (iPSCs); mesenchymal and pluripotent stem cells

(This special issue belongs to the Section Tissues and Organs)

Microautophagy: The Least Known of the Autophagy Strategies

edited by

Patrice X. Petit

submission deadline 28 Feb 2026 | Viewed by 143 | Submission Open

Keywords: core autophagy machinery; ESCRT machinery; lysosomophagy; membrane fission; membrane fusion; microautophagy; SNAREs

(This special issue belongs to the Section Autophagy)

The Lipid Metabolism and Signaling in Dry Eye Disease

edited by Ni Made Airanthi Kusuma Widjaja-Adhi and Marcin Golczak

submission deadline 28 Feb 2026 | Viewed by 133 | Submission Open

Keywords: lipid metabolism; meibogenesis; dry eye disease (DED); meibomian gland dysfunction (MGD); ocular surface; neuroinflammation; tear film; lipidomics; spatial transcriptomics; therapeutics development; molecular mechanisms

Displaying special issue 301-350 on page 7 of 13.

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