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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Select Topics in Molecular and Cellular Mechanisms of Mammalian Reproduction

edited by Zhengui Zheng,

Brent M. Bany

and Liang Ma

submission deadline 20 Jul 2026 | 7 articles | Viewed by 19555

Keywords: reproductive organ development; sexual differentiation; reproductive tract function; fertilization; implantation; placentation; parturition; lactation

(This special issue belongs to the Section Reproductive Cells and Development)

The Roles of the Extracellular Matrix in Cardiac Structure and Function: A Commemorative Issue in Honor of Dr. Thomas K. Borg

edited by

Wayne Carver

and Edie Goldsmith

submission deadline 20 Jul 2026 | 9 articles | Viewed by 17181

Keywords: collagen; integrin; extracellular matrix; cardiomyocyte; fibroblast; heart bioengineering

(This special issue belongs to the Section Cell Microenvironment)

Insights into the Pathophysiology of NeuroCOVID: Current Topics

edited by

Christian Barbato

Antonio Minni

and

Carla Petrella

submission deadline 20 Jul 2026 | 4 articles | Viewed by 9734

Keywords: neuroCOVID; longCOVID; neurocognitive; cellular and molecular neurobiology; brain fog; anxiety; depression; biomarkers; translational biomedicine; neurodegenerative diseases

(This special issue belongs to the Section Cellular Pathology)

Mitochondria at the Crossroad of Health and Disease—Second Edition

edited by

Nickolay Brustovetsky

submission deadline 20 Jul 2026 | 7 articles | Viewed by 9613

Keywords: mitochondria; oxidative phosphorylation; mitochondrial ion transport; permeability transition pore; mitochondrial ROS generation; mitochondrial quality control; mitochondrial traffic; mitochondrial morphology; mitochondrial dynamics; mitophagy

(This special issue belongs to the Section Cellular Aging)

Second Edition of Advances in Adipose Tissue Biology

edited by

Melvin K. S. Leow

submission deadline 20 Jul 2026 | 2 articles | Viewed by 6233

Keywords: adipocyte differentiation, progenitors, and stem cells; adipokines, myokines, hepatokines, cytokines, cellular signaling, and molecular crosstalk; white adipose tissue (WAT) and brown adipose tissue (BAT); beige fat and browning of WAT; research techniques and methodologies; diagnostics and therapeutics, genomics, metabolomics, other ‘omics’ technologies; metabolic syndrome, obesity, insulin resistance, cancer

(This special issue belongs to the Section Tissues and Organs)

Cancer and Immune System Interactions

edited by

Hong-Jian Zhu

and

Bradley Creamer

submission deadline 20 Jul 2026 | 4 articles | Viewed by 3725

Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor–immune interactions; immune checkpoint regulation; translational oncology

(This special issue belongs to the Section Cell Microenvironment)

Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment

edited by Shashi Anand

submission deadline 20 Jul 2026 | 1 articles | Viewed by 862

Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance

(This special issue belongs to the Section Cellular Metabolism)

Clockwork Cells: Decoding the Language of Cell Cycle Regulators

edited by

Guanxiong Yan

, Kyung-sang Lee,

Richard W. Wong

and

Gary S. Stein

submission deadline 20 Jul 2026 | 1 articles | Viewed by 760

Keywords: cyclins; cyclin-dependent kinases (CDKs); checkpoints; cell proliferation; mitosis; meiosis

(This special issue belongs to the Section Cell Proliferation and Division)

Impact of Chronic Substance Exposure on Hematopoiesis and Immunity

edited by

Mary Mohrin

and

Hami Hemati

submission deadline 20 Jul 2026 | Viewed by 402

Keywords:

Substance Use

Alcohol

Immunity

Inflammation

Hematopoietic stem and progenitor cells

Monocytes

Neutrophils

Macrophages

T cells

Cellular and Molecular Research of Plant-Derived Exosomes

edited by Mukesh Kumar Sriwastva

submission deadline 20 Jul 2026 | Viewed by 332

Keywords: plant-derived exosomes; extracellular vesicles; exosome isolation and characterization; cross-kingdom communication; therapeutic applications; biomolecule cargo (proteins, RNAs, lipids); plant exosome-like nanoparticles; drug delivery systems

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Applications of Nanotechnology and Molecular Imaging in Cancer

edited by

Zheng-Rong Lu

and Victoria Laney

submission deadline 20 Jul 2026 | Viewed by 261

Keywords: contrast agents and mechanisms; probes; molecular imaging; longitudinal imaging; tumor microenvironment; nanomaterials; cell signaling; cancer therapy; intracellular pathways; imaging-guided treatment

A New Frontier for Cancer Diagnosis and Therapy

edited by

Concettina La Motta

Md Manirujjaman

and

A.S.M. Waliullah

submission deadline 25 Jul 2026 | 1 articles | Viewed by 2063 | Submission Open

Keywords: cancer diagnosis; precision oncology; liquid biopsy; molecular biomarkers; immunotherapy; targeted therapy; nanomedicine; multi-omics; artificial intelligence; tumor heterogeneity

(This special issue belongs to the Section Cellular Immunology)

Molecular Regulation of Trophoblast Invasion in Placental Function and Pregnancy Disorders

edited by Mirjana Nacka-Aleksić

submission deadline 25 Jul 2026 | 1 articles | Viewed by 289 | Submission Open

Keywords: trophoblast invasion; preeclampsia; placenta accreta; human trophoblast stem cells

(This special issue belongs to the Section Reproductive Cells and Development)

Harnessing the Immune System: Emerging Therapeutic Strategies in Cancer

edited by Kishan Shamjibhai Italiya

submission deadline 25 Jul 2026 | Viewed by 228 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; adoptive cell therapy; cancer vaccines; T cell therapy; immuno-oncology; tumor immune evasion; immune modulation; antitumor immunity

(This special issue belongs to the Section Cellular Immunology)

Applications of Proteomics in Human Diseases and Treatments

edited by

Giovanni Cuda

and

Marco Gaspari

submission deadline 30 Jul 2026 | 3 articles | Viewed by 4237 | Submission Open

Keywords: biomarkers; clinical proteomics; single-cell proteomics; next-generation proteomics; biofluids; high-throughput proteomics

(This special issue belongs to the Section Cell Methods)

Osteoporosis Treatment: Targeting Osteoclast and Osteoblast Function with microRNA Therapeutics

edited by

Aijaz Ahmad John Bhat

submission deadline 30 Jul 2026 | 1 articles | Viewed by 2814 | Submission Open

Keywords: osteoporosis; microRNA; osteoblasts; osteoclasts; osteocytes; fracture; bone remodeling

(This special issue belongs to the Section Tissues and Organs)

New Advances in Immunomodulation Using Biomaterials

edited by

Gundula Schulze-Tanzil

and Vaishali Inamdar

submission deadline 30 Jul 2026 | 1 articles | Viewed by 1307 | Submission Open

Keywords: immunomodulation; biomaterials; cell–material interactions; biocompatibility; immune system

Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy

edited by

Toshimichi Onuma

and

Jianjun Wei

submission deadline 30 Jul 2026 | Viewed by 287 | Submission Open

Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies

(This special issue belongs to the Section Cellular Pathology)

Targeted Therapy and Immunotherapy in Breast Cancer: Molecular Mechanisms and Translational Advances

edited by Saranya Chumsri, Hatem H. Soliman and

Aixa Elena Soyano

submission deadline 30 Jul 2026 | Viewed by 282 | Submission Open

Keywords: breast cancer; targeted therapy; immunotherapy; biomarkers of response; therapeutic resistance

(This special issue belongs to the Section Cellular Immunology)

Cellular Mechanisms of Anti-Cancer Therapies

edited by Ilgen Mender and

Kazuyuki Kitatani

submission deadline 31 Jul 2026 | 8 articles | Viewed by 32771 | Submission Open

Keywords: anti-cancer therapies; innovative treatment strategies; cellular mechanisms; drug resistance; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies

edited by

Agnieszka Bojarska-Junak

and

Michal Zarobkiewicz

submission deadline 31 Jul 2026 | 6 articles | Viewed by 19116 | Submission Open

Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Vascular-Related Diseases

edited by

Bingmei Fu

and

Ye Zeng

submission deadline 31 Jul 2026 | 9 articles | Viewed by 13850 | Submission Open

Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system

(This special issue belongs to the Section Cellular Pathology)

Advances in the Cellular and Molecular Mechanisms of Cardiovascular Diseases

edited by

Timothy Martin Palmer

and Katie S. Wraith

submission deadline 31 Jul 2026 | 8 articles | Viewed by 13543 | Submission Open

Keywords: thrombosis; smooth muscle; endothelium; atherosclerosis; inflammation

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advances in the Discovery of Retinal Degeneration

edited by

Ram Prasad

and

Yvonne Adu-Rutledge

submission deadline 31 Jul 2026 | 6 articles | Viewed by 11871 | Submission Open

Keywords: retinal cell biology; photoreceptors; oxidative stress; inflammation; blood–retinal barriers; diabetic retinopathy; clinical eye research; inherited retinal diseases; ocular immunology

(This special issue belongs to the Section Cellular Pathology)

Mechanisms of Lung Growth and Regeneration

edited by

Saverio Bellusci

and

Yuanlin Song

submission deadline 31 Jul 2026 | 5 articles | Viewed by 11311 | Submission Open

Keywords: stem cells; niche; aging; growth factors; extracellular matrix; organoids; fibrosis; single-cell RNAseq

(This special issue belongs to the Section Cell Microenvironment)

Adipose Tissue Functioning in Health and Diseases

edited by Richard C Chang

submission deadline 31 Jul 2026 | 6 articles | Viewed by 9370 | Submission Open

Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance

(This special issue belongs to the Section Tissues and Organs)

Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer

edited by

Madalina Anca Moldovan

and

Ciprian Tomuleasa

submission deadline 31 Jul 2026 | 5 articles | Viewed by 7516 | Submission Open

Keywords: tumor microenvironment; epithelial–mesenchymal transition (EMT); tumor–stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology

Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities

edited by

Thomas Nicholson

submission deadline 31 Jul 2026 | 3 articles | Viewed by 7013 | Submission Open

Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies

(This special issue belongs to the Section Cellular Pathology)

Cellular and Molecular Mechanisms in Neuropsychiatric and Neurological Disorders

edited by Irina Balan

submission deadline 31 Jul 2026 | 4 articles | Viewed by 6947 | Submission Open

Keywords: cellular mechanisms; molecular mechanisms; neuropsychiatric disorders; neurological disorders; neuroinflammation; neuronal signaling; gene expression; synaptic function; glial cells; peripheral factors

(This special issue belongs to the Section Cellular Pathology)

The Role of Pancreatic Beta-Cells in Obesity and Type 2 Diabetes

edited by Mayur Doke, Juan Domínguez-Bendala and Oscar Alcazar

submission deadline 31 Jul 2026 | 4 articles | Viewed by 6336 | Submission Open

Keywords: pancreatic beta-cells; GLP-1; obesity; type 2 diabetes; islet biology; beta-cell regeneration; insulin resistance; incretin therapies; single-cell transcriptomics; metabolic stress

Cellular and Molecular Mechanisms of Heart Diseases

edited by

Sumita Mishra

submission deadline 31 Jul 2026 | 2 articles | Viewed by 6141 | Submission Open

Keywords: heart failure; HFrEF; HFpEF; molecular signaling; therapeutic interventions; ejection fraction; fibrosis; metabolism; mitochondrial dysfunction; cardiovascular therapies

(This special issue belongs to the Section Cellular Pathology)

Regulation of Ca²⁺ Signals in Human Disease

edited by Yandong Zhou

submission deadline 31 Jul 2026 | 4 articles | Viewed by 4970 | Submission Open

Keywords: calcium signaling; cellular homeostasis; disease mechanisms; calcium channels; therapeutic targets

(This special issue belongs to the Section Cell Signaling)

Advances in Smart and Innovative Nanoparticles for Precision Tumor Therapy: Design, Delivery, Immune Modulation, and Clinical Translation

edited by Hari Krishnareddy Rachamala and

Naga Malleswara Rao Nakka

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4564 | Submission Open

Keywords: smart nanoparticles; tumor-targeted drug delivery; immune modulation; stimuli-responsive nanocarriers; clinical translation in oncology

(This special issue belongs to the Section Cell Methods)

Integrated Approaches Between Metabolomics and Cellular Aging

edited by Maria Nikolaou and

Nikolaos Theodorakis

submission deadline 31 Jul 2026 | 2 articles | Viewed by 4469 | Submission Open

Keywords: metabolomics; cellular aging; senescence; mitochondrial dysfunction; DNA damage; biomarkers; metabolism

(This special issue belongs to the Section Cellular Aging)

Genetic Mechanisms in Cellular Genomics and Therapeutics

edited by Elaine T. Lim and Yingleong Chan

submission deadline 31 Jul 2026 | 1 articles | Viewed by 4279 | Submission Open

Keywords: genetics of human diseases; functional genomics; cellular mechanisms; genomics or stem cell technologies; therapeutics research and development for human diseases

Epigenetic Mechanisms of Tumorigenesis

edited by

Hengbin Wang

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3967 | Submission Open

Keywords: epigenetics; tumorigenesis; gene expression; cell identity; precise medicine

Standardization and Metrological Advancements in Cellular and Genomic Diagnostics for Cancer

edited by

Jessica Petiti

and Marika Fava

submission deadline 31 Jul 2026 | 1 articles | Viewed by 3562 | Submission Open

Keywords: cancer diagnostics; cellular analysis; genomic profiling; precision medicine; metrology in diagnostics; next generation sequencing (NGS); reference measurement systems (RMSs); quality assurance (QA); IVDR compliance; SI-traceable standards

Cellular and Molecular Mechanisms of Neurotoxicity

edited by

Anna Andrioli

Idris Azeez

, Tiziana Cotrufo and

Olumayowa Igado

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3337 | Submission Open

Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate

The Language of Neural Cells: Decoding Molecular Signaling in Neurodevelopmental and Neuro-Oncological Disorders

edited by

Marilena Briglia

Alice Foti

and Adriana C. E. Graziano

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2928 | Submission Open

Keywords: neural cells; molecular signaling; neurodevelopmental disorders; neuro-oncological disorders; transcriptional dysregulation

(This special issue belongs to the Section Cellular Neuroscience)

The Role of Cell Signaling Pathway Starvation Therapy for Cancer

edited by

Niramol Savaraj

and Min You

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2219 | Submission Open

Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways

(This special issue belongs to the Section Cell Signaling)

Aquaporins at the Crossroads of Human Health and Disease

edited by

Anna Patrizia Gena

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1663 | Submission Open

Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics

Rho Family Small GTPases in Health and Diseases

edited by

Katalin Szászi

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1571 | Submission Open

Keywords: Rho signalling; Rho guanine nucleotide exchange factor; Rho GTPase-activating protein; Rho effector; dysregulation of Rho GTPases; Rho pathway inhibitors

(This special issue belongs to the Section Cell Signaling)

AI and Multi-Modal Data Integration in Neurobiology and Neurological Diseases

edited by Jeon Lee

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1356 | Submission Open

Keywords: artificial intelligence; multi-modal integration; multi-omics; neurobiology; neurological disease; molecular characterization; neuronal biomarker; cellular pathway

(This special issue belongs to the Section Cellular Neuroscience)

Application of Stem Cells and Cellular Engineering in Musculoskeletal Tissue Regeneration

edited by

Alessandra Colombini

submission deadline 31 Jul 2026 | 2 articles | Viewed by 1060 | Submission Open

Keywords: mesenchymal stem cells (MSCs); tissue specific progenitors; cellular engineering; musculoskeletal tissue regeneration; tissue engineering; biomaterials; 3D culture systems; mechanobiology; extracellular vesicles; translational regenerative medicine

(This special issue belongs to the Section Stem Cells)

Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer—2nd Edition

edited by Sachin Mulik, Weshely Kujur,

Engin Berber

and Sumit Sen Santara

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1044 | Submission Open

Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes

(This special issue belongs to the Section Cellular Immunology)

Advances in Toxoplasma gondii Treatment, Immunology and Host–Parasite Interaction

edited by

Namrata Anand

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1021 | Submission Open

Keywords: T. gondii; treatment strategies; secretory proteins; immune response; exosomes; nanoparticle; congenital infection; host–parasite interaction

(This special issue belongs to the Section Cellular Immunology)

Immunometabolic Reprogramming in Diabetic Kidney Disease: The Interplay of Innate Immunity, Oxidative Stress, and Cellular Metabolism

edited by

Nela Kelam

, Sandra Kostić and Anita Racetin

submission deadline 31 Jul 2026 | 1 articles | Viewed by 637 | Submission Open

Keywords: diabetic kidney disease; immunometabolism; innate immunity; oxidative stress; metabolic reprogramming; inflammasome; renal fibrosis; mitochondrial dysfunction; non-coding RNAs; multi-omics integration

ALK Signaling Pathways in NSCLC: From Cell Biology to Therapeutic Insights

edited by

Edyta Maria Urbanska

and

Eric Santoni-Rugiu

submission deadline 31 Jul 2026 | Viewed by 404 | Submission Open

Keywords: anaplastic lymphoma kinase (ALK); non-small-cell lung cancer (NSCLC); ALK tyrosine kinase inhibitors (ALK-TKIs); drug resistance; signal transduction and oncogenic pathways; molecular diagnostics (IHC, FISH, NGS); targeted therapy

Is Gene Therapy the Answer to Overcoming Diabetes?

edited by

Ann Simpson

and

Najah Therese Nassif

submission deadline 31 Jul 2026 | Viewed by 376 | Submission Open

Keywords: gene therapy; type 1 diabetes; type 2 diabetes; glycemic control; beta-cell transcription factors; insulin granules; viral vectors

Extracellular Vesicles: Drivers, Biomarkers and Therapeutics in Cardiovascular Disease

edited by

Prabhu Mathiyalagan

submission deadline 31 Jul 2026 | Viewed by 343 | Submission Open

Keywords: cardiovascular disease; extracellular vesicles; biomarkers; therapeutics; drug delivery; RNA therapeutics; fibrosis; atherosclerosis; liquid biopsy

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