Endothelial Dysfunction in Vascular Diseases
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 10 March 2026 | Viewed by 16
Special Issue Editor
Interests: endothelial dysfunction; vascular diseases; atherosclerosis; hypertension
Special Issue Information
Dear Colleagues,
Endothelial dysfunction is a key factor in the development of cardiovascular and metabolic diseases, as it promotes vascular damage through oxidative stress, reduced nitric oxide bioavailability, and chronic inflammation. As the primary interface between blood and tissues, the endothelium plays a crucial role in vascular health by regulating vascular tone, permeability, coagulation, and immune responses. Under physiological conditions, this balance is maintained by mediators such as nitric oxide and prostacyclins; however, in the presence of chronic inflammation, hyperglycemia, dyslipidemia, and oxidative stress, this equilibrium is disrupted, leading to a pro-inflammatory and pro-thrombotic state.
This Special Issue will explore the complex interplay between endothelial dysfunction, inflammation, and metabolic dysregulation in vascular diseases, including, for example, atherosclerosis and hypertension. Emerging research on the role of inflammation in vascular injury and potential therapeutic strategies targeting endothelial repair and protection will also be highlighted. Early recognition of endothelial dysfunction through novel biomarkers and imaging techniques is increasingly regarded as essential for effective prevention and treatment. By advancing the understanding of these processes, this collection aims to promote innovative research and therapeutic approaches to reduce the global burden of cardiovascular diseases.
We invite the submission of original research articles and reviews elucidating the role of endothelial dysfunction in vascular pathology.
Dr. Antonio Nesci
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- endothelial dysfunction
- vascular diseases
- atherosclerosis
- oxidative stress
- nitric oxide
- hypertension
- vascular inflammation
- endothelial repair
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