Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms of Cell Death in Neurodegenerative Diseases
edited by and Emmanouil Metzakopian
submission deadline 10 Dec 2026 | Viewed by 346 | Submission Open
Keywords: cell death; neurodegenerative diseases; molecular biology; genomics; neuroinflammation; protein aggregation; neurobiology; mitochondria dysfunction
Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders submission deadline 10 Dec 2026 | Viewed by 307 | Submission Open
Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast
Molecular Mechanisms and Targeting Strategies of the Blood–Brain Barrier
edited by Kasandra Bélanger
submission deadline 10 Dec 2026 | Viewed by 273 | Submission Open
Keywords: blood–brain barrier; homeostasis; neurovascular unit; drug delivery; neurorological disorders; BBB integrity; permeability; molecular pathways
(This special issue belongs to the Section Cellular Neuroscience)
Advances in Maternal–Fetal Immunity
edited by
submission deadline 10 Dec 2026 | Viewed by 239 | Submission Open
Keywords: maternal–fetal immunity; developmental immunoregulation; pregnancy immune plasticity; fetal programming; pregnancy immunology
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular and Cellular Mechanisms of Inherited Retinal Diseases
edited by Holly Yu Chen
submission deadline 10 Dec 2026 | Viewed by 193 | Submission Open
Keywords: inherited retinal diseases; retinal degeneration; retinal organoids; müller glia; retinal pigment epithelium
(This special issue belongs to the Section Cellular Pathology)
Cellular Origin of Glioma: From Triggers to Treatments submission deadline 15 Dec 2026 | 2 articles | Viewed by 2991 | Submission Open
Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells
Brain Function and Structure: Mapping Complexity in Neuronal Cells submission deadline 15 Dec 2026 | 1 articles | Viewed by 2522 | Submission Open
Keywords: optogenetics; lab-on-chip platforms and brain organoids; neuronal and glial networks; neuromechanobiology; system neuroscience
From Molecular Mechanisms to Treatment Progress of Ovarian Cancer
edited by Amal M. El-Naggar
submission deadline 15 Dec 2026 | 3 articles | Viewed by 2411 | Submission Open
Keywords: ovarian cancer; molecular mechanisms; therapeutic targets; drug resistance; biomarkers; preclinical models; targeted therapy; immunotherapy; tumor microenvironment; translational research
(This special issue belongs to the Section Reproductive Cells and Development)
Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation
edited by and Osvaldo Bogado Pascottini
submission deadline 15 Dec 2026 | Viewed by 382 | Submission Open
Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling
Role of Hippo Signaling in Cancer submission deadline 15 Dec 2026 | Viewed by 336 | Submission Open
Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis
(This special issue belongs to the Section Cell Signaling)
Immune Cell Plasticity and Dysfunction in Hepatocellular Carcinoma and Viral Hepatitis
edited by
submission deadline 15 Dec 2026 | Viewed by 215 | Submission Open
Keywords: T cell exhaustion; chronic infection; anti-tumor immune response; hepatocellular carcinoma; tumor-infiltrating CD8+; T-cell subpopulations; immunometabolism; tumor microenvironment
(This special issue belongs to the Section Cellular Immunology)
Advances in the Biology and Treatment of T-Cell Lymphoma submission deadline 16 Dec 2026 | Viewed by 491 | Submission Open
Keywords: T-cell lymphoma; cancer biology; oncogenic signaling; cellular mechanisms; cell–cell interactions; targeted therapy
(This special issue belongs to the Section Cellular Immunology)
Innovations in mRNA Delivery Vectors submission deadline 16 Dec 2026 | Viewed by 254 | Submission Open
Keywords: mRNA delivery systems; lipid nanoparticles (LNPs); non-viral vectors; targeted RNA delivery; extracellular vesicles
Development and Characterization of Innovative In Vitro Models
edited by Fengyan Deng and Chongbei Zhao
submission deadline 18 Dec 2026 | 1 articles | Viewed by 2063 | Submission Open
Keywords: 3D organoid development; iPSC; iPSC reprogramming; primary cell derivation; cell immortalization; disease model development; stem cell therapy; molecular biology; cell signaling
Hypoxia and the Immune Landscape in Infection and Cancer
edited by Bernard Burke
submission deadline 18 Dec 2026 | 1 articles | Viewed by 1428 | Submission Open
Keywords: hypoxia; tumor; infection; HIFs; immune checkpoint proteins; immune evasion; metabolic dysregulation; leukocyte recruitment; effector cell function; acidosis
(This special issue belongs to the Section Cellular Immunology)
Soluble Niche Factors Regulating Neural Stem Cells in Development and Disease
edited by
submission deadline 20 Dec 2026 | Viewed by 176 | Submission Open
Keywords: neural stem cells; niche; soluble factors; development; disease
(This special issue belongs to the Section Stem Cells)
Therapeutic Targets in Glioblastoma—Second Edition
edited by and Candice Mazewski
submission deadline 20 Dec 2026 | Viewed by 93 | Submission Open
Keywords: glioblastoma; signaling targets; blood–brain barrier; complementary and alternative medicine; combination therapy; glioma stem cells; progression; resistance; nutrient-sensing
(This special issue belongs to the Section Cellular Neuroscience)
Lipid Mediators in Cardiometabolic Regulation and Disease
edited by Adeniyi Michael Adebesin
submission deadline 21 Dec 2026 | Viewed by 234 | Submission Open
Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins
(This special issue belongs to the Section Cellular Metabolism)
Targeting Hallmarks of Cancer submission deadline 25 Dec 2026 | 3 articles | Viewed by 8498 | Submission Open
Keywords: epigenetic regulators; organotypic culture models; anticancer drugs; hallmarks of cancer
Cellular Pathology: Emerging Discoveries and Perspectives in the USA submission deadline 31 Dec 2026 | 4 articles | Viewed by 13736 | Submission Open
Keywords: cellular pathology; diseases; mechanisms
(This special issue belongs to the Section Cellular Pathology)
Going with the Flow and Beyond: Understanding Benign Blood Disorders and Their Underlying Mechanisms
edited by Tirthadipa Pradhan-Sundd
submission deadline 31 Dec 2026 | 2 articles | Viewed by 3889 | Submission Open
Keywords: benign blood disorders; sickle cell disease; red blood cells; hemoglobin; heme; iron overload; organ damage; hemophilia; thalassemia; anemia; blood vessels; vascular aging; endothelial cells
Exclusive Reviews on Autophagy: From Molecular Mechanisms to Therapeutic Frontiers
edited by and Daolin Tang
submission deadline 31 Dec 2026 | 2 articles | Viewed by 3594 | Submission Open
Keywords: autophagy; macro-autophagy; micro-autophagy; lysosomal degradation; adaptation to stresses; physiological functions and pathological situations
(This special issue belongs to the Section Autophagy)
Melatonin in Neuroprotection: Mechanisms, Mitochondria, and Therapeutic Potential submission deadline 31 Dec 2026 | 1 articles | Viewed by 1788 | Submission Open
Keywords: neurodegenerative disorders; melatonin, neuroprotection; mitochondria; oxidative stress; neuroinflammation; mitochondrial dynamics; therapeutic potential
(This special issue belongs to the Section Mitochondria)
Cellular and Molecular Mechanisms in Endocrine Regulation
edited by Ovidiu Nicolae Pop and
submission deadline 31 Dec 2026 | 1 articles | Viewed by 693 | Submission Open
Keywords: endocrine regulation; cellular signaling; hormone secretion; molecular endocrinology; signal transduction; endocrine cells; nuclear receptors; endocrine homeostasis; cellular communication; endocrine disorders
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms Regulating Keratinocyte Biology, Barrier Function, and Skin Inflammation
edited by and
submission deadline 31 Dec 2026 | Viewed by 289 | Submission Open
Keywords: keratinocytes; skin barrier; skin inflammation
(This special issue belongs to the Section Cellular Pathology)
Cellular and Molecular Mechanisms of Retinal Diseases
edited by Ravirajsinh N. Jadeja and Menaka C. Thounaojam
submission deadline 31 Dec 2026 | Viewed by 228 | Submission Open
Keywords: retinal diseases; cellular and molecular mechanisms; retinal development; degeneration; oxidative stress; hypoxia; inflammation; cell signaling; metabolic regulation; vascular pathology; translational retinal research
(This special issue belongs to the Section Tissues and Organs)
The Role of Glial Cells in the Nervous System
edited by and Lindsey Goodman
submission deadline 31 Dec 2026 | Viewed by 215 | Submission Open
Keywords: glia; astrocytes; microglia; oligodendrocytes; Schwann cells; lipids; inflammation; immunity; neurodegeneration; neurodevelopment
(This special issue belongs to the Section Cellular Neuroscience)
Immuno-Cardiology: Immune Mechanisms from Ischemia to Heart Failure
edited by Djamel Lebeche
submission deadline 31 Dec 2026 | Viewed by 202 | Submission Open
Keywords: cardiology; immune system; inflammation; ischemic injury; heart failure; immunometabolism; immunotherapy; nanomedicine; fibrotic remodeling; scar immunology; systems immunology
(This special issue belongs to the Section Cellular Immunology)
Emerging Topics in Vascular Endothelial Cell Biology—Second Edition
edited by
submission deadline 31 Dec 2026 | Viewed by 147 | Submission Open
Keywords: endothelial cells; endothelial dysfunction; cancer; coronary artery disease; inflammation; angiogenesis
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Mechanisms in Male Fertility submission deadline 31 Dec 2026 | Viewed by 132 | Submission Open
Keywords: male fertility; spermatogenesis; testicular function; germ cell development; spermatozoa; molecular signaling; infertility mechanisms; reproductive health; epigenetic regulation
(This special issue belongs to the Section Reproductive Cells and Development)
Special Issue in Honor of Academician Yi-Xun Liu on the Occasion of His 90th Birthday
edited by Shoulong Deng
submission deadline 31 Dec 2026 | Viewed by 128 | Submission Open
Keywords: reproductive physiology; ovarian function; spermatogenesis; gonadotropins; granulosa cells
(This special issue belongs to the Section Reproductive Cells and Development)
The Role of Exosomes in Regulating Mechanisms of Tumor Growth and Progression
edited by and
submission deadline 31 Dec 2026 | Viewed by 44 | Submission Open
Keywords: extracellular vesicles; exosomes; tumor biology; metastasis; immune modulations; biomarkers; therapeutics
(This special issue belongs to the Section Intracellular and Plasma Membranes)
The Evolution of the Tumor Microenvironment (TME) and Its Role in Neoplastic Progression and Chemoresistance submission deadline 31 Dec 2026 | Viewed by 8 | Submission Open
Keywords: desmoplasia; ECM; hypoxia; stroma; accessory cells; growth factors; acidity; vascular anomalies; TME directed therapy; EMT; chemoresistance; reprogrammed metabolism
(This special issue belongs to the Section Cell Microenvironment)
Cellular and Molecular Mechanisms in Cancer Immunology and Immunotherapy
edited by and Dan Zhao
submission deadline 31 Dec 2026 | Viewed by 5 | Submission Open
Keywords: antibody; vaccine; CAR T cells; cancer prevention; immune checkpoint blockade; tumor microenvironment
(This special issue belongs to the Section Cellular Immunology)
Cellular and Molecular Biochemistry in Natural Products Research
edited by , Stefano Putaggio and
submission deadline 1 Jan 2027 | Viewed by 27 | Submission Open
Keywords: natural products; bioactive metabolites; molecular and cellular mechanisms; redox homeostasis; cell signaling; programmed cell death; mitochondrial dysfunction; metabolic regulation; translational biochemistry
(This special issue belongs to the Section Cellular Metabolism)
The Placental Matrix: Trophoblasts, Decidualization, and Embryo Implantation
edited by
submission deadline 15 Jan 2027 | 1 articles | Viewed by 2708 | Submission Open
Keywords: trophoblast; decidualization; embryo implantation; uterus; infection; cancer; reproductive immunology; reproductive toxicology; cellular differentiation
(This special issue belongs to the Section Tissues and Organs)
New Insights into Astrocytes in Health and Disease
edited by
submission deadline 15 Jan 2027 | 2 articles | Viewed by 2301 | Submission Open
Keywords: astrocytes heterogeneity; blood-brain barrier (BBB); synaptic modulation; metabolic support; neuroinflammation; ageing; neurodegenerative disorders; neurodevelopmental disorders; stress response
(This special issue belongs to the Section Cellular Neuroscience)
Inflammation in the Brain: Cellular Interactions, Molecular Pathways and Translation Toward Novel Therapies submission deadline 15 Jan 2027 | Viewed by 360 | Submission Open
Keywords: neuroinflammatory pathways; inflammasome; neurodegeneration
(This special issue belongs to the Section Cellular Neuroscience)
Systemic Sclerosis: Cellular Mechanisms, Innovative Diagnostics and Advanced Therapeutics
edited by Muhammad Soyfoo
submission deadline 15 Jan 2027 | Viewed by 295 | Submission Open
Keywords: systemic sclerosis; fibrosis; myofibroblasts; immune dysregulation; endothelial dysfunction; extracellular matrix (ECM); autoimmune disease
Signaling Dynamics in Cancer
edited by Claudia Voena, Riccardo Taulli and Francesca Bersani
submission deadline 15 Jan 2027 | Viewed by 272 | Submission Open
Keywords: cancer signaling; cancer biology; tumor microenvironment; tumor progression; biomarkers; therapeutics
(This special issue belongs to the Section Cell Signaling)
Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities
edited by Victoria McGilligan
submission deadline 15 Jan 2027 | Viewed by 262 | Submission Open
Keywords: atherosclerosis; inflammation; inflammatory biomarkers; anti-inflammatory therapies; plaque vulnerability; diagnostics and prognostics
The Orchestration of Glial Cells in Health and Disease
edited by Keying Zhu
submission deadline 20 Jan 2027 | 1 articles | Viewed by 2369 | Submission Open
Keywords: microglia; oligodendrocytes; astrocytes; myelin; neuroinflammation
Molecular Anatomy and Function of Sensory Organs and Sensory Tissues
edited by
submission deadline 20 Jan 2027 | 2 articles | Viewed by 2344 | Submission Open
Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs
(This special issue belongs to the Section Tissues and Organs)
The Dynamic Tumor Microenvironment: Mechanisms of Therapy Resistance and Opportunities for Intervention
edited by Ahmed Lasfar and
submission deadline 20 Jan 2027 | Viewed by 163 | Submission Open
Keywords: tumor microenvironment/TME; therapeutic resistance; mechanisms
(This special issue belongs to the Section Cell Microenvironment)
Advances in Human Pluripotent Stem Cells submission deadline 25 Jan 2027 | 5 articles | Viewed by 10564 | Submission Open
Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells
(This special issue belongs to the Section Stem Cells)
New Advances in Tissue Engineering and Regeneration submission deadline 25 Jan 2027 | 6 articles | Viewed by 8156 | Submission Open
Keywords: tissue regeneration; tissue engineering; regenerative medicine; musculoskeletal tissues; biomaterials; stem cells; 3D bioprinting; scaffold design; cell therapy; organoids; translational research
(This special issue belongs to the Section Tissues and Organs)
Cutaneous Regeneration and Tissue Engineering: From Hair Follicle Regeneration to Skin Restoration
edited by Soung-Hoon Lee
submission deadline 25 Jan 2027 | 4 articles | Viewed by 4484 | Submission Open
Keywords: skin regeneration; hair follicle regeneration; tissue engineering; regenerative biology; biomaterial scaffolds; organoids and 3D skin models; wound healing; acellular matrices; exosome-based therapy; translational dermatology
Therapeutic Targeting of Myeloid Cells in Tumor
edited by Mirko Farina and
submission deadline 25 Jan 2027 | Viewed by 281 | Submission Open
Keywords: myeloid cells; therapeutic targeting; tumor microenvironment; leukemia; myelodysplastic syndromes; tumor development
Emerging Topics in Smooth Muscle Cell Fate and Plasticity in Atherosclerosis submission deadline 29 Jan 2027 | 6 articles | Viewed by 14385 | Submission Open
Keywords: vascular smooth muscle cells; lineage tracing; fate mapping; VSMC plasticity; (single cell) (spatial) omics; vascular heterogeneity; atherosclerosis
(This special issue belongs to the Section Cellular Pathology)
Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease submission deadline 29 Jan 2027 | 4 articles | Viewed by 7492 | Submission Open
Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell–cell communication; cell signaling
(This special issue belongs to the Section Cells of the Cardiovascular System)
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