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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Inherited Metabolic Disorders

edited by Paul Gissen

submission deadline 28 Feb 2026 | Viewed by 13 | Submission Open

Keywords: metabolic disorders; enzyme defects; protein misfolding; metabolic pathways; cellular metabolism; molecular pathology; disease mechanisms; therapeutic targets; organelle dysfunction; metabolic networks

(This special issue belongs to the Section Cellular Metabolism)

Omics Technologies for Understanding Cell Pathophysiology

edited by

Ciro Isidoro

Annalisa Chiocchetti

and

Alessandra Ferraresi

submission deadline 10 Mar 2026 | Viewed by 270 | Submission Open

Keywords: epigenomics; cytomics; immunomics; exosomics; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 10 Mar 2026 | Viewed by 7 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

Oral Tissue Stem Cells in Regenerative Dentistry

edited by

Jelena Milasin

and

Miloš M. Lazarević

submission deadline 15 Mar 2026 | 5 articles | Viewed by 12803 | Submission Open

Keywords: oral tissue stem cells; oral tissue regeneration; dental materials; stem cell-derived exosomes; stem cell engineering

(This special issue belongs to the Section Stem Cells)

Nanofluidics, Nanopores, and Nanomaterials for Understanding Biology

edited by

Malgorzata A. Witek

submission deadline 15 Mar 2026 | 2 articles | Viewed by 2722 | Submission Open

Keywords: nanofluidics; nanopores; nanomaterials; biology; biochemistry; bioengineering; biotechnology; drug delivery; sequencing; reaction kinetics; single-molecule detection

(This special issue belongs to the Section Cell Methods)

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Mar 2026 | Viewed by 131 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

Retinal Pigment Epithelium Dysfunction in Retinal Disorders: Pathophysiology and Therapeutic Strategies

edited by

Deepthi Rajendran Nair

and Sushma Kalmodia

submission deadline 15 Mar 2026 | Viewed by 27 | Submission Open

Keywords: retinal pigment epithelium (RPE); inherited retinal disease; RPE dysfunction

(This special issue belongs to the Section Tissues and Organs)

New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells

edited by

Karuppusamy Shanmugapriya

submission deadline 20 Mar 2026 | 7 articles | Viewed by 16035 | Submission Open

Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment

(This special issue belongs to the Section Cell Methods)

New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics

edited by

Uta Flucke

submission deadline 20 Mar 2026 | 3 articles | Viewed by 4392 | Submission Open

Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Cardiomyopathy

edited by

Zaglia Tania

and

Maurizio Forte

submission deadline 30 Mar 2026 | Viewed by 25 | Submission Open

Keywords: genetic cardiomyopathies; acquired cardiomyopathies; cardiac arrhythmias; disease mechanisms; disease cause; pathogenesis

(This special issue belongs to the Section Tissues and Organs)

Flow Cytometry in Immunology Research

edited by

Ziv Porat

and Ekaterina Kopitman

submission deadline 31 Mar 2026 | 2 articles | Viewed by 7012 | Submission Open

Keywords: multi-parametric analysis; full-spectrum flow cytometry; imaging flow cytometry; immuno-phenotyping; immune synapse; cytokines; activation markers; cancer immunology; host-pathogen interactions; functional immune assays

(This special issue belongs to the Section Cell Methods)

Current Research on Immunotherapy for Glioblastoma

edited by Markella Zannikou

submission deadline 31 Mar 2026 | Viewed by 149 | Submission Open

Keywords: GBM; tumor microenvironment; cancer vaccines; TIL (tumor-infiltrating lymphocytes) therapy; combination therapy; BiTEs; immune checkpoint therapy; CAR T-cell therapy; peptide/dendritic vaccines; tumor-associated antigens; oncolytic virotherapy

(This special issue belongs to the Section Cellular Immunology)

The Challenges and Opportunities of Mesenchymal Stromal Cells in Regenerative Medicine

edited by

Lucie Bacakova

submission deadline 31 Mar 2026 | Viewed by 20 | Submission Open

Keywords: mesenchymal stromal cells; mesenchymal stem cells; medicinal signaling cells; multipotent stem cells; paracrine secretion; angiogenesis; immunomodulation; cell therapy; cell-free cell-based therapy; stem cell differentiation; tissue engineering

Cellular and Molecular Mechanisms in Aging

edited by Michel Satya Naslavsky and Mateus Vidigal

submission deadline 1 Apr 2026 | Viewed by 170 | Submission Open

Keywords: cellular senescence; aging models; DNA repair; neurodegeneration; elderly

(This special issue belongs to the Section Cellular Aging)

Mast Cells in Health and Disease: Current Insights and Future Perspectives on Development, Activation, Functional Roles, and Therapeutic Strategies

edited by

Aida Paivandy

submission deadline 15 Apr 2026 | Viewed by 465 | Submission Open

Keywords: mast cell granules; mast cell mediators; mast cell development; mast cell survival; mast cell activation; mast cell activating and inhibitory receptors; receptor signaling; allergic and non-allergic pathologies; immunity and host defense; mast cell-directed therapeutic approaches

(This special issue belongs to the Section Cellular Immunology)

Novel Therapeutic Targets and Approaches, Genetic Markers and Signaling Pathways in Neoplasms

edited by

Daria A. Chudakova

and

Kazuyuki Kitatani

submission deadline 20 Apr 2026 | 10 articles | Viewed by 22886 | Submission Open

Keywords: cancer; neoplasms; personalized medicine; genetic markers; next-generation sequencing (NGS); whole-genome sequencing; signaling pathways in cancer; novel therapeutic targets; drug development

(This special issue belongs to the Section Cell and Gene Therapy)

Chromosomal Instability in Health and Disease

edited by Anna V. Roschke

submission deadline 20 Apr 2026 | 3 articles | Viewed by 3471 | Submission Open

Keywords: chromosomal instability; aneuploidy; polyploidy; cancer evolution; chromosomal instability and aneuploidy in embryonic development; chromosomal instability and polyploidy in evolutionary process; somatic aneuploidy in senescence and ageing

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Recent Advances in Novel Cell and Gene Therapies for the Treatment of Immune Diseases

edited by Qingdong Guan

submission deadline 20 Apr 2026 | 1 articles | Viewed by 1314 | Submission Open

Keywords: cell therapy; gene therapy; chimeric antigen receptor T cells; T cell receptor-engineered T cells; tumor-infiltrating lymphocytes; hematopoietic stem cells; chimeric antigen receptor NK cells; induced pluripotent stem cells; mesenchymal stem/stromal cells; immune regulatory cells

(This special issue belongs to the Section Cellular Immunology)

pH Sensing, Signaling, and Regulation in Cellular Processes

edited by Maike Glitsch

submission deadline 20 Apr 2026 | Viewed by 281 | Submission Open

Keywords: extra- and intracellular pH; pH sensing; signaling; and regulation; pH-dependent receptors; proton signaling; ion channels; G-protein-coupled receptors; cell biology and function; physiological and pathological processes; aging; cancer; inflammation; and so on; novel therapeutic strategies and targets

(This special issue belongs to the Section Cell Signaling)

Role of Gamma Delta T Cells in Immunotherapy

edited by

Dieter Kabelitz

and Wenwei Tu

submission deadline 30 Apr 2026 | Viewed by 312 | Submission Open

Keywords: gamma delta T cells; adoptive cell therapy; chimeric antigen receptors; bispecific antibodies; cancer immunotherapy; tumor microenvironment; phosphoantigens; butyrophilin 2A1/3A1; virus infection; multidrug-resistant bacteria; extracellular vesicles

(This special issue belongs to the Section Cellular Immunology)

Retinal Disorders: Cellular Mechanisms and Targeted Therapies

edited by

Takeshi Iwata

submission deadline 15 May 2026 | 2 articles | Viewed by 3814 | Submission Open

Keywords: inherited eye diseases; genome; omics; gene editing; iPS cells; animal models; single cell analysis; AI; epigenetics

(This special issue belongs to the Section Cellular Pathology)

Diabetes-Induced Organ Damage: Cellular Mechanisms and Therapeutic Opportunities

edited by

Mohammed S. Razzaque

submission deadline 30 Jun 2026 | 5 articles | Viewed by 13935 | Submission Open

Keywords: diabetes mellitus; vascular lesions; nephropathy; cardiomyopathy; neuropathy; retinopathy; therapeutic opportunities

(This special issue belongs to the Section Tissues and Organs)

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Jun 2026 | Viewed by 8 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

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