Lipid Mediators in Cardiometabolic Regulation and Disease

Dear Colleagues,

Lipid mediators (LMs), including bioactive lipids such as prostaglandins, leukotrienes, epoxylipids, endocannabinoids, specialized pro-resolving mediators, ceramides, sphingolipids, and sterols, are potent signaling molecules and key regulators of cellular metabolism, signaling, and homeostasis. Research on these LMs has contributed immensely to our understanding of how their diverse biophysical and biochemical properties encode information for intra- and intercellular crosstalk in cardiometabolic (CDM) processes and yielded efficacious therapies for CDM diseases (CDMDs). Despite significant progress in this research area, critical knowledge gaps remain, including the following: (1) roles of specific LMs in CDMD; (2) the identity of bioactive metabolites of LMs involved in CDMD; (3) signaling mechanisms available to LMs; (4) proteins involved in the biosynthesis, trafficking, sensing, and inactivation of LMs; and (5) cellular compartments involved in the bioactions of LMs. This Special Issue aims to augment our understanding of the roles of LMs in CDMD by integrating diverse mechanistic perspectives that highlight LMs as central modulators of CDMD.

We welcome research articles, perspectives, and reviews that elucidate biosynthetic pathways, intracellular signaling networks, paracrine and inter-tissue crosstalk, and the functional and therapeutic roles of LMs in cardiometabolic regulation.

Dr. Adeniyi Michael Adebesin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.