Signaling Dynamics in Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: 31 July 2026 | Viewed by 15
Special Issue Editors
Interests: cell signaling; cell culture; cancer biology; cancer therapy; hematological malignancies; lymphoma; ALK oncogene
2. Molecular Biotechnology Center “Guido Tarone”, University of Turin, 10126 Turin, Italy
Interests: cancer biology; tumorigenesis; cancer epigenetics; RNA biology in cancer; cancer therapy
Interests: cancer biology; translational biochemistry; preclinical models; cancer metabolism; repeat elements; lung cancer; patient-derived organoids; circulating tumor cells
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cellular signaling networks operate as spatiotemporally regulated dynamic systems, governing core biological processes such as proliferation, differentiation, and cell survival. Dysregulation of signaling dynamics (including aberrant temporal activation, feedback/feedforward loops, and altered crosstalk between pathways) lies at the heart of cancer initiation and progression, driving malignant transformation by disrupting cellular homeostasis. Elucidating the dynamic properties of oncogenic signaling, moving beyond conventional static pathway analyses, is essential to uncover novel molecular mechanisms of tumor development and address key gaps in our understanding of how signaling networks adapt and rewire in cancer cells. However, despite decades of research, our overall understanding of how cancer cell signaling circuits are regulated— and how they influence cancer progression and therapy resistance—remains incomplete.
This Special Issue aims to highlight cutting-edge basic research that explores the molecular principles governing signaling dynamics in cancer. We invite submissions of original research articles and comprehensive reviews that provide new insights into the intrinsic dynamics of oncogenic signaling networks. Topics of interest include, but are not limited to, the following: (1) mechanistic signaling research in cancer progression; (2) spatiotemporal regulation of oncogenic signaling pathways; (3) feedback/feedforward loops mediating signaling plasticity; (4) post-translational modifications (e.g., phosphorylation and ubiquitination) in signaling dynamics; (5) intercellular signaling crosstalk within the tumor microenvironment; and (6) modeling approaches to study signaling dynamics.
We look forward to hearing from you.
Dr. Claudia Voena
Dr. Riccardo Taulli
Dr. Francesca Bersani
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cancer signaling
- cancer biology
- tumor microenvironment
- tumor progression
- biomarkers
- therapeutics
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