Cellular and Molecular Mechanisms in Male Fertility
A Special Issue of Cells (ISSN 2073-4409) belonging to the section "Reproductive Cells and Development".
Deadline for manuscript submissions: 31 December 2026 | Viewed by 598
Editors
Interests: male (in)fertility and reproduction; sperm biology; aging; endocrine disruptors; biomarkers; RNA; protein-protein interactions; contraception
Interests: human fertility; reproductive toxicology; environmental pollutants; lifestyle factors; cell signalling pathways and biomarkers
Special Issue Information
Dear Colleagues,
Male fertility is a complex trait regulated by coordinated cellular and molecular processes. Despite significant advances in reproductive biology, infertility affects a growing number of men worldwide, highlighting the urgent need to better understand the underlying mechanisms. Advances in molecular biology and reproductive technologies are now revealing the intricate networks that govern spermatogenesis, testicular function and hormonal regulation. This Special Issue aims to highlight cutting-edge research that uncovers the cellular and molecular mechanisms underlying male fertility, from germ cell development and Sertoli–Leydig cell interactions to epigenetic regulation and signaling pathways critical for fertility. We particularly welcome original research, reviews and perspective articles leveraging state-of-the-art approaches, such as single-cell omics, advanced imaging, CRISPR-based models and integrative systems biology, as well as contributions exploring genetic, environmental and lifestyle impacts on male reproductive function, to provide novel mechanistic insights or translational potential for diagnosis, therapy and fertility preservation. By bringing together the latest discoveries in cellular and molecular reproductive science, this Special Issue seeks to provide a comprehensive, forward-looking resource that will advance our understanding of male fertility and inspire new strategies for improving reproductive outcomes. We invite the scientific community to submit their work, with the aim of creating a high-impact collection that will serve as a key reference and stimulus for the future of male fertility research.
Dr. Joana Santiago
Dr. Magda Carvalho Henriques
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- male fertility
- spermatogenesis
- testicular function
- germ cell development
- spermatozoa
- molecular signaling
- infertility mechanisms
- reproductive health
- epigenetic regulation
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