Inflammation and Atherosclerosis: Emerging Mechanisms, Biomarkers and Therapeutic Opportunities

Dear Colleagues,

In recent years, growing evidence has established inflammation as a central driver of atherosclerotic plaque initiation, progression, and destabilisation. Advances in molecular and imaging technologies have unveiled complex interactions between immune, vascular, and metabolic pathways that govern plaque vulnerability and contribute to acute cardiovascular events. At the same time, the identification of novel inflammatory biomarkers and signalling mediators is opening new avenues for the development of diagnostic tools and targeted therapeutic strategies.

In this Special Issue on inflammation and atherosclerosis, we aim to highlight recent discoveries in the field, encompassing fundamental mechanistic insights as well as translational and clinical advances. Topics will include inflammatory pathways involved in plaque destabilisation, emerging biomarkers for risk stratification, innovative imaging approaches, and novel anti-inflammatory or immunomodulatory interventions.

We welcome original research articles, perspectives, and comprehensive review papers that advance understanding of inflammation-driven atherosclerosis and promote the development of strategies to predict and prevent plaque rupture and its clinical consequences.

Dr. Victoria McGilligan
Guest Editor

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