Innovations in mRNA Delivery Vectors
Special Issue Editor
2. Centre de Recherche du Centre Hospitalier Universitaire de Québec, Québec, QC G1E 6W2, Canada
Interests: Duchenne muscular dystrophy; Friedreich's ataxia; Alzheimer’s disease; CRISPR; base editing; myoblast transplantation
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Special Issue Information
Dear Colleagues,
We are thrilled to announce a Special Issue entitled “Innovations in mRNA Delivery Vectors.” mRNA delivery systems have become central to modern molecular and cellular research, enabling precise control of gene expression, protein production, and cell fate engineering. Rapid progress in vector design—spanning lipid nanoparticles, polymers, peptides, and hybrid biomaterials—has significantly expanded the landscape of mRNA technologies. Emerging insights into intracellular trafficking, vector–membrane interactions, and mRNA stabilization are driving the development of more efficient, tunable, and cell-selective delivery systems. This Special Issue aims to highlight cutting-edge discoveries, methodologies, and conceptual advances that deepen our understanding of mRNA delivery biology and broaden its research applications.
The papers in this Special Issue will focus on the latest findings related to mRNA delivery vectors. Topics will include, but are not limited to, the following:
- Structural and mechanistic insights into mRNA vector design and function;
- Cellular uptake, transport, and endosomal escape of mRNA carriers;
- mRNA stability, translation efficiency, and intracellular fate;
- Targeted delivery strategies informed by receptor biology and cell signaling;
- Advanced tools and assays for analyzing mRNA delivery at the single-cell or systems level;
- Delivery by lipid nanoparticles (LNPs);
- Delivery by extracellular vesicles (EVs).
We invite original research articles, reviews, and perspectives that present novel discoveries and critical analyses relevant to mRNA vector development. All submissions will undergo rigorous peer review to ensure scientific excellence and relevance.
Prof. Dr. Jacques P. Tremblay
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- mRNA delivery systems
- lipid nanoparticles (LNPs)
- non-viral vectors
- targeted RNA delivery
- extracellular vesicles
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