Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 31 May 2026 | Viewed by 191 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 31 May 2026 | Viewed by 190 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cellular Neuroscience)
Inflammatory Signaling and Vascular Dysfunction in Atherosclerosis
edited by and Jianzhong Shen
submission deadline 31 May 2026 | Viewed by 168 | Submission Open
Keywords: inflammation in atherosclerosis; atherothrombosis; cell signaling
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 31 May 2026 | Viewed by 165 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
Cellular and Molecular Mechanisms of Heart Development
edited by Jun K. Takeuchi
submission deadline 31 May 2026 | Viewed by 148 | Submission Open
Keywords: heart development; cardiovascular; epigenetics; cell fate; differentiation; cardiac growth; cardiac morphogenesis; heart regeneration; cardiac organoid
Extracellular Vesicles in Reproductive Communication: From Gametogenesis to Implantation
edited by and Osvaldo Bogado Pascottini
submission deadline 31 May 2026 | Viewed by 148 | Submission Open
Keywords: extracellular vesicles; reproductive biology; gametogenesis; oocyte maturation; embryo-maternal communication; implantation; reproductive disorders; epigenetic regulation; EV Cargo; intercellular signaling
Mitochondria Beyond Energy: Signaling, Immunity, and Cell Fate submission deadline 31 May 2026 | Viewed by 141 | Submission Open
Keywords: mitochondria; stem cells; cell fate; organogenesis; immunometabolism
Cancer and Vessels: Insights at the Cellular and Molecular Levels
edited by Francesco Pezzella and Tom Donnem
submission deadline 31 May 2026 | Viewed by 139 | Submission Open
Keywords: angiogenesis; vessel co-option; tumor microenvironment; tumor blood vessels; tumor vasculature; metastasis
(This special issue belongs to the Section Cellular Pathology)
Regulatory Mechanisms of Vascular Smooth Muscle Cells and Immune Cells in Vascular Disease Progression
edited by and
submission deadline 31 May 2026 | Viewed by 138 | Submission Open
Keywords: vascular smooth muscle cells; immune cells; inflammation; vascular disease; atherosclerosis; aneurysm; cellular crosstalk; phenotypic transition
(This special issue belongs to the Section Cells of the Cardiovascular System)
Immunotherapy-Induced Cardiotoxicity: Unraveling the Immune Landscape of Myocarditis
edited by
submission deadline 31 May 2026 | Viewed by 133 | Submission Open
Keywords: immunotherapy; immune checkpoints; adoptive cell therapy; cardiac adverse events; cardiac inflammation; immune checkpoint inhibitor associated myocarditis; cardiac immune landscape; innate immune response; adaptive immune response; myeloid cells; macrophages; antigen presentation & phagocytosis; T cells; T cell clonality; cytokines; chemokines; chemotaxis; immune crosstalk; immune– stromal crosstalk; multi-omics
Skeletal Muscle Aging and Regeneration: Mitochondrial Health, Molecular Signaling, and Therapeutic Interventions
edited by
submission deadline 31 May 2026 | Viewed by 131 | Submission Open
Keywords: aging; skeletal muscle; regeneration; satellite cells; muscle stem cells; muscle wasting; mitochondria; fibro-adipogenic progenitor cells; repair
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 31 May 2026 | Viewed by 130 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
(This special issue belongs to the Section Tissues and Organs)
Molecular Mechanisms and Therapeutic Strategies for Skeletal Muscle Disorders submission deadline 31 May 2026 | Viewed by 106 | Submission Open
Keywords: skeletal muscle; muscular disorders; myokines; muscle regeneration; muscle atrophy; inflammation; stress response; myoblast
Cellular and Molecular Pathways in Immune Tolerance and Autoimmune Regulation
edited by
submission deadline 31 May 2026 | Viewed by 105 | Submission Open
Keywords: immune tolerance; autoimmune regulation; immune homeostasis; regulatory T cells; regulatory B cells; cytokine networks; molecular mechanisms; therapeutic strategies
(This special issue belongs to the Section Cellular Immunology)
B Cells in Action: Interaction Dynamics and Functional Decisions
edited by Michael L. Atchison and
submission deadline 31 May 2026 | Viewed by 103 | Submission Open
Keywords: B cell development and differentiation; adaptive immunity; germinal center B cell; class-switch recombination; immunosuppression; cytokines; inflammation; epigenetic regulation; metabolic reprogramming; immune response
(This special issue belongs to the Section Cellular Immunology)
DNA Damage and Repair in Targeted Cancer Therapy
edited by Mohd Saleem Dar, Sajad Ahmad Bhat and
submission deadline 31 May 2026 | Viewed by 98 | Submission Open
Keywords: cancer cells; DNA damage and repair mechanism; genome organization; BER; NER; MMR; HR; and NHEJ; targeted therapy; inhibitors/PROATCS; drug resistance; drug toxicity; biomarkers; personalized medicine
Advances in Ion Channel Biology: From Molecular Mechanisms to Therapeutic Targets
edited by Shridhar Sanghvi, and
submission deadline 31 May 2026 | Viewed by 95 | Submission Open
Keywords: ion channels; electrophysiology; cryo-electron microscopy; channelopathy; membrane protein; gating mechanism; structural biology
Cellular Responses to Heavy Metals: From Intestinal Uptake to Disease submission deadline 31 May 2026 | Viewed by 91 | Submission Open
Keywords: cadmium (Cd) bioavailability; heavy metal intestinal uptake; heavy metal-induced cardiotoxicity; heavy metal-induced neurotoxicity; heavy metal-induced osteotoxicity; heavy metals and malignancies
Epigenetic and Cellular Regulation in Hematologic Disorders
edited by
submission deadline 31 May 2026 | Viewed by 90 | Submission Open
Keywords: epigenetics; hematologic disorders; leukemia; myelodysplastic syndrome; thrombosis; thrombocytopenia; bleeding
Cellular Mechanisms and Therapeutic Potentials of Neurodevelopmental Defects submission deadline 31 May 2026 | Viewed by 88 | Submission Open
Keywords: neurodevelopmental disorders; neuronal connectivity; precocious therapies; synaptic plasticity; neurogenesis; glial function
(This special issue belongs to the Section Cellular Neuroscience)
Endometrial Cancer: From Molecular Mechanisms to Therapeutic Approaches
edited by Tomaž Büdefeld and
submission deadline 31 May 2026 | Viewed by 76 | Submission Open
Keywords: endometrial cancer; genetic mutation; epigenetics; cell signaling; TIME; metastasis; biomarker; therapy; drug delivery; risk factor
Decoding Heart Failure: From Mechanisms to Treatment
edited by and Dirk L. Brutsaert
submission deadline 31 May 2026 | Viewed by 62 | Submission Open
Keywords: heart failure; pathological process; molecular mechanisms; cellular mechanisms; genetic mechanisms; therapeutic target
Stem Cell-Based Strategies for Cardiac Tissue Engineering and Regeneration
edited by Munira Xaymardan and
submission deadline 31 May 2026 | Viewed by 53 | Submission Open
Keywords: cardiac tissue engineering; stem cells; cardiomyocytes; cardiac organoids; engineered heart tissues; biomaterials; scaffolds; gene therapy; RNA reprogramming; cardiac fibrosis; cardiac regeneration; myocardial repair; translational studies
(This special issue belongs to the Section Stem Cells)
Molecular Bases Underlying Early Embryonic Development in Mammals
edited by , Julio Ávila Marrero and Angela Palumbo
submission deadline 31 May 2026 | Viewed by 50 | Submission Open
Keywords: embryonic development; early embryogenesis; gene expression; miRNA profile; reproductive physiology; cell signalling; embryo quality; developmental competence; in vitro embryo culture
(This special issue belongs to the Section Reproductive Cells and Development)
Modeling Lung Regeneration and Injury Responses Using Organoids and Engineered Niches
edited by Tristan Frum
submission deadline 31 May 2026 | Viewed by 45 | Submission Open
Keywords: lung biology; regeneration; stem cells; intra- and extracellular signaling; cell techniques; organoids; bioengineering
(This special issue belongs to the Section Tissues and Organs)
Advancements in Research on Metabolic Syndrome
edited by Gautam Kumar Pandey
submission deadline 31 May 2026 | Viewed by 44 | Submission Open
Keywords: metabolic syndrome; multi-omics; insulin resistance; cell signaling in metabolic disease
Cellular Metabolism and Immune Regulation in Cancer Progression and Metastasis
edited by Xu Jing
submission deadline 31 May 2026 | Viewed by 39 | Submission Open
Keywords: cellular metabolism; tumor immunology; cancer progression; metastasis; immunometabolism; metabolic reprogramming; tumor microenvironment; immune evasion; cancer therapy; metabolic biomarkers
(This special issue belongs to the Section Cellular Metabolism)
Human Pluripotent Stem Cells and Organoids: Current Trends and Future Perspectives submission deadline 1 Jun 2026 | 1 articles | Viewed by 978 | Submission Open
Keywords: human pluripotent stem cells; organoids; disease modeling; regenerative medicine; genome editing; single-cell omics; tissue engineering; drug discovery; precision medicine
(This special issue belongs to the Section Stem Cells)
Molecular Mechanisms of Fibrosis in Chronic Liver Diseases
edited by , Regina Golan-Gerstl and Ihab Ansari
submission deadline 1 Jun 2026 | Viewed by 214 | Submission Open
Keywords: liver fibrosis; MASH; immune checkpoints; epigenetic regulation; hepatic stellate cells (HSCs); antifibrotic therapy; molecular mechanisms; inflammation; ROS
Mechanisms, Biomarkers, and Therapeutics of Neurodegeneration
edited by
submission deadline 1 Jun 2026 | Viewed by 31 | Submission Open
Keywords: neurodegeneration; biomarkers; mechanistic studies; protein aggregation; protein degradation; neuroinflammation; targeted therapies; genetics; precision medicine
(This special issue belongs to the Section Cellular Neuroscience)
Macrophages in Cancer: Immunosuppression, Immunoregulation, and Immunotherapy
edited by
submission deadline 5 Jun 2026 | 3 articles | Viewed by 12507 | Submission Open
Keywords: macrophage; immunosuppression; immunoregulation; immunotherapy; tumor immune microenvironment
(This special issue belongs to the Section Cellular Immunology)
Novel Insights into Molecular Mechanisms and Therapy of Myeloma
edited by and
submission deadline 10 Jun 2026 | 7 articles | Viewed by 19139 | Submission Open
Keywords: multiple myeloma; CAR-T therapy; relapse; methylation; drug resistance; treatment strategy; molecular mechanism; novel target; biomarker
(This special issue belongs to the Section Cellular Pathology)
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 10 Jun 2026 | 1 articles | Viewed by 1384 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
Molecular Mechanisms of Cardiac Repair and Regeneration
edited by Mahesh Thirunavukkarasu
submission deadline 10 Jun 2026 | Viewed by 125 | Submission Open
Keywords: cardiac repair and regeneration; cardiomyocyte; cardiac fibrosis; signaling pathways; immune regulation; extracellular vesicles; stem cell therapies; epigenetics; biomarkers
(This special issue belongs to the Section Cells of the Cardiovascular System)
The Metabolic Edge: How Cancer Cells Adapt, Survive, and Resist Therapy
edited by
submission deadline 10 Jun 2026 | Viewed by 106 | Submission Open
Keywords: cancer metabolism; metabolic rewiring; therapy resistance; metabolic plasticity; nutrient uptake; mitochondrial remodeling; tumor microenvironment; metabolic vulnerabilities
(This special issue belongs to the Section Cellular Metabolism)
Lipid Mediators in Cardiometabolic Regulation and Disease
edited by Adeniyi Michael Adebesin
submission deadline 10 Jun 2026 | Viewed by 58 | Submission Open
Keywords: lipid mediators; lipoprotein; fatty acid metabolites; cellular membranes; cardiometabolic regulation; cellular metabolism; adipogenesis; signaling pathways; receptors; lipid transport proteins
(This special issue belongs to the Section Cellular Metabolism)
The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition
edited by and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 3914 | Submission Open
Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular Origin of Glioma: From Triggers to Treatments
edited by Katherine Karakoula
submission deadline 15 Jun 2026 | Viewed by 390 | Submission Open
Keywords: glioblastoma; brain tumour; tumour heterogeneity; targeted therapy; glioma stem cells
Novel Insights into Developing Therapeutic Strategies for Neurological Disorders
edited by , Joanna A. Korecka and
submission deadline 15 Jun 2026 | 1 articles | Viewed by 291 | Submission Open
Keywords: neurological disorders; RNA therapeutics; gene therapy; antisense oligonucleotides; gene editing; cell therapy; precision medicine; neurodegenerative diseases; neurodevelopmental disorders; neurogenetic disorders
Regulation of Hormone Secretion from Islets in Health and Disease
edited by
submission deadline 15 Jun 2026 | Viewed by 220 | Submission Open
Keywords: islet hormone secretion; paracrine signaling; autocrine regulation; intra-islet communication; islet cell plasticity; transdifferentiation; multi-hormonal dysregulation; circadian regulation; single-cell omics; islet inflammation and immune crosstalk
Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 15 Jun 2026 | Viewed by 166 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Bone and Soft Tissue Tumors: Molecular Mechanisms and Emerging Therapeutics
edited by
submission deadline 15 Jun 2026 | Viewed by 138 | Submission Open
Keywords: sarcoma; bone and soft tissue tumors; molecular pathology; dysregulated signaling pathways; genetic and epigenetic alterations; therapeutic resistance; novel molecular biomarkers; therapeutic strategies; in vitro and in vivo models
Overcoming Resistance to Immune Checkpoint Inhibitors in Cancer: Mechanisms, Models, and Therapeutic Strategies
edited by Nai-Yun Sun, and
submission deadline 15 Jun 2026 | Viewed by 104 | Submission Open
Keywords: immune checkpoint inhibitors; primary resistance; acquired resistance; tumor microenvironment; immune exhaustion; preclinical cancer models; genetic and epigenetic alterations; excluded/desert tumors; inflamed tumors; cancer immunotherapy
Molecular Mechanism of Liver Transplantation
edited by Carmen Peralta and Juan Carlos Cutrin
submission deadline 20 Jun 2026 | 1 articles | Viewed by 4456 | Submission Open
Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies
(This special issue belongs to the Section Tissues and Organs)
Decoding the Complexity of Angiogenesis: Insights into Vascular Formation and Disease submission deadline 20 Jun 2026 | 3 articles | Viewed by 3625 | Submission Open
Keywords: angiogenesis; vasculogenesis; development; physiological angiogenesis; pathophysiology; cell– cell communication; cell signaling
(This special issue belongs to the Section Cells of the Cardiovascular System)
Mechanisms of Antimicrobial Treatment in Human Diseases
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 3065 | Submission Open
Keywords: multidrug resistance; epidemiology; novel antimicrobial resistance traits
(This special issue belongs to the Section Cellular Pathology)
Biomolecular Condensates in Oncology and Immunology submission deadline 20 Jun 2026 | 1 articles | Viewed by 1749 | Submission Open
Keywords: liquid-liquid phase separation (LLPS); biomolecular condensates; pro-oncogenic signaling; innate and adaptive immunity; transcriptional regulation; epigenetic regulation; condensate targeting; antiviral mechanisms; intercellular adhesion; cell migration and metastasis
(This special issue belongs to the Section Cellular Immunology)
Progress of Nanoparticles in the Treatment of Cancers
edited by and Nafees Ahamad
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1545 | Submission Open
Keywords: nanoparticles; cancer treatment; cellular mechanisms; molecular biology; pathophysiology; drug delivery; drug resistance; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Cell Microenvironment)
Beyond Bystanders: The Emerging Roles of Glia in Brain Health and Disease
edited by
submission deadline 20 Jun 2026 | 1 articles | Viewed by 1085 | Submission Open
Keywords: astrocytes; microglia; oligodendrocytes; neuroinflammation; neuroimmunology; synaptic plasticity; blood– brain barrier; neuropsychiatric disorders
(This special issue belongs to the Section Cellular Neuroscience)
Molecular Anatomy and Function of Sensory Organs and Sensory Tissues
edited by
submission deadline 20 Jun 2026 | Viewed by 339 | Submission Open
Keywords: sensory organ; sensory tissue; vision; hearing; skin; sensory structures of internal organs
(This special issue belongs to the Section Tissues and Organs)
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