The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

Dear Colleagues,

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. The production of reactive oxygen species (ROS) in the heart and blood vessels plays an essential role in maintaining the homeostasis of the cardiovascular system. However, ROS production is a double-edged sword. Transient and low-level ROS production within the cardiovascular system triggers cell signaling pathways that lead to hormetic adaptation. In contrast, the continuous production or accumulation of high levels of ROS results in pathological injury in the cardiomyocytes and vascular cells.

Oxidative stress occurs when the overproduction of ROS overwhelms the elimination ability of antioxidants. Accumulating evidence has shown that oxidative stress plays a critical role in the development and progression of CVD and has also been associated with mitochondrial dysfunction and chronic inflammation in the cardiovascular system. Cardiovascular risk factors include dietary habits, physical activity, smoking, metabolic syndromes, hypertension, high lipid levels, and chronic inflammation, all of which are related to oxidative stress and the overall impact of CVD incidence and outcome. Targeting the underlying molecular mechanism to regulate ROS production and oxidative stress may enable the development of novel and effective therapeutic strategies against various cardiovascular disorders. However, it is still an enigma as to how the comprehensive oxidative stress-related signaling pathways are orchestrated in cardiovascular physiology and pathology contexts.

This Special Issue of Cells aims to address the complexity of ROS signaling in CVD, to update our knowledge on the regulation of oxidative stress in cardiovascular disorders, and to identify potential clinical therapeutical targets. We welcome original research and review articles on state-of-the-art technologies and the latest findings in the field. Moreover, this Special Issue will cover broad aspects of these critical scientific areas, from in vitro cellular studies to the in vivo physiological and pathological aspects of oxidative stress in the cardiovascular system.

Dr. Liya Yin
Dr. Chuanxi Cai
Guest Editors

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