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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular and Molecular Mechanisms in Sepsis: Pathogenesis, Immune Response, and Therapeutic Strategies

edited by

Bogdan Pavel

and

Mingui Fu

submission deadline 28 Feb 2026 | Viewed by 98 | Submission Open

Keywords: sepsis; cytokine signaling; immune cell dynamics; epigenetic regulation; metabolic reprogramming; non-coding RNAs; redox signaling; receptor polymorphisms; systems immunology; single-cell omics

(This special issue belongs to the Section Cellular Pathology)

The Role of Cell Signaling Pathway Starvation Therapy for Cancer

edited by

Niramol Savaraj

and Min You

submission deadline 28 Feb 2026 | Viewed by 76 | Submission Open

Keywords: signaling pathways; nutrient deprivation; starvation therapy; metabolic reprogramming; metabolic pathways

(This special issue belongs to the Section Cell Signaling)

Advanced Cell-Analyzing Technologies and Their Biosensing Applications

edited by

Tiean Zhou

and

Linhong Deng

submission deadline 28 Feb 2026 | Viewed by 66 | Submission Open

Keywords: cell analysis; biosensors; single-cell technologies; microfluidics; organ-on-a-chip; AI-driven biosensing diagnostics; nanotechnology; cell mechanics; cellular function analysis; cell phenotype assays

Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer

edited by

Madalina Anca Moldovan

and

Ciprian Tomuleasa

submission deadline 1 Mar 2026 | Viewed by 278 | Submission Open

Keywords: tumor microenvironment; epithelial– mesenchymal transition (EMT); tumor– stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology

Synaptic Senescence in Health and Neurodegeneration: Cellular and Molecular Mechanisms

edited by

Isabel Martinez-Pena y Valenzuela

submission deadline 9 Mar 2026 | Viewed by 265 | Submission Open

Keywords: synapses; synaptic transmission; aging; senescent synapse; neurodegeneration; synaptic plasticity; glial cells

Gene Expression in Adipocytes During Obesity: Understanding Challenges and Future Prospects

edited by

Markus Mandl

submission deadline 10 Mar 2026 | 1 articles | Viewed by 1938 | Submission Open

Keywords: adipocytes; adipose tissue; obesity; hypoxia; transcription factor; metabolism; epigenetics

Omics Technologies for Understanding Cell Pathophysiology

edited by

Ciro Isidoro

Annalisa Chiocchetti

and

Alessandra Ferraresi

submission deadline 10 Mar 2026 | Viewed by 397 | Submission Open

Keywords: epigenomics; cytomics; immunomics; exosomics; personalized medicine

(This special issue belongs to the Section Cellular Pathology)

Targeting Tumor Suppressor Genes for Cancer Therapy

edited by Jogendra Pawar, Smita Kumari and Naseem Akhter

submission deadline 10 Mar 2026 | Viewed by 396 | Submission Open

Keywords: tumor suppressor genes; cancer therapy; gene editing; CRISPR-Cas9; DNA damage repair; oncogenic signaling; immunotherapy; tumor microenvironment; artificial intelligence; personalized medicine

Endothelial Dysfunction in Vascular Diseases

edited by Antonio Nesci

submission deadline 10 Mar 2026 | Viewed by 187 | Submission Open

Keywords: endothelial dysfunction; vascular diseases; atherosclerosis; oxidative stress; nitric oxide; hypertension; vascular inflammation; endothelial repair

α-Synuclein in Parkinson’s Disease

edited by

Maria Ilenia De Bartolo

and

Matteo Costanzo

submission deadline 10 Mar 2026 | Viewed by 173 | Submission Open

Keywords: α -synuclein; protein aggregation; neurodegeneration; Parkinson’ s disease; clinical subtypes; biomarkers; detection techniques; disease heterogeneity; prognostic stratification; translational neuroscience

Neural Governance of Gastrointestinal Motility

edited by Jiande Chen

submission deadline 10 Mar 2026 | Viewed by 159 | Submission Open

Keywords: enteric nervous system; gastrointestinal motility; neural circuitry; neurotransmitter signaling; smooth muscle regulation; neuron– epithelial; organoid models; gut-brain axis; neuro-immune interaction; neuromodulation

Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis III

edited by

Ralf Weiskirchen

submission deadline 15 Mar 2026 | 7 articles | Viewed by 23956 | Submission Open

(This special issue belongs to the Section Tissues and Organs)

Oral Tissue Stem Cells in Regenerative Dentistry

edited by

Jelena Milasin

and

Miloš M. Lazarević

submission deadline 15 Mar 2026 | 6 articles | Viewed by 19113 | Submission Open

Keywords: oral tissue stem cells; oral tissue regeneration; dental materials; stem cell-derived exosomes; stem cell engineering

(This special issue belongs to the Section Stem Cells)

Nanofluidics, Nanopores, and Nanomaterials for Understanding Biology

edited by

Malgorzata A. Witek

submission deadline 15 Mar 2026 | 2 articles | Viewed by 3974 | Submission Open

Keywords: nanofluidics; nanopores; nanomaterials; biology; biochemistry; bioengineering; biotechnology; drug delivery; sequencing; reaction kinetics; single-molecule detection

(This special issue belongs to the Section Cell Methods)

Molecular and Cellular Research on Spinal Cord Injury

edited by

Vinnitsa Buzoianu-Anguiano

and

Jörg Mey

submission deadline 15 Mar 2026 | 1 articles | Viewed by 2491 | Submission Open

Keywords: spinal cord injury; growth inhibitory factors; axonal regeneration; neuroprotection; combined therapies; cell trasnplants; regenerative medicine; inhibition scar formation; extracellular matrix molecules

(This special issue belongs to the Section Cellular Pathology)

Glioblastoma Cells: From Cellular and Molecular Mechanisms to Innovative Therapy—2nd Edition

edited by

Antonella Arcella

submission deadline 15 Mar 2026 | Viewed by 469 | Submission Open

Keywords: glioma; glioblastoma; glioma stem cells (GSCs); MGMT methylation; EGFR signaling; apoptosis; autophagy; molecular-targeted therapy; personalized medicine; radiotherapy; glioma cell biology; prognostic biomarkers; in vitro glioma models; in vivo glioblastoma studies

Glioblastoma Horizons: Exploring Mechanisms and Advancing Therapeutic Strategies

edited by Yang Wu and Julio Plata-Bello

submission deadline 15 Mar 2026 | Viewed by 394 | Submission Open

Keywords: glioblastoma heterogeneity; tumor microenvironment; 3D cell culture models; therapeutic resistance mechanisms; immunotherapy

Phytofactories: From Lab to Applications

edited by

and

submission deadline 15 Mar 2026 | Viewed by 344 | Submission Open

Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Role of Ras-Regulated Signal Pathways

edited by

Takayuki Tsukuba

submission deadline 15 Mar 2026 | Viewed by 301 | Submission Open

Keywords: Ras-regulated signaling pathway; MAPK/ERK pathway; PI3K/AKT pathway; Ral-GDS pathway

(This special issue belongs to the Section Cell Signaling)

Host–Pathogen Interactions and Immune Responses

edited by Harish Chandra

submission deadline 15 Mar 2026 | Viewed by 142 | Submission Open

Keywords: multidrug-resistant bacteria; environmental mycobacteria; exosomes; oxidative stress; catalases; antimicrobial resistance; polycyclic aromatic hydrocarbons (PAHs); cellular signaling

(This special issue belongs to the Section Cellular Immunology)

Targeting Metabolic Vulnerabilities to Selectively Eliminate Cancer Cells

edited by Nina Semenova and

Juan Sebastián Yakisich

submission deadline 15 Mar 2026 | Viewed by 124 | Submission Open

Keywords: cancer cell metabolism; cancer cell signaling pathways; cancer epigenetic regulation; nutrient deprivation; tumor microenvironment; chemotherapy; chemoresistance; radiotherapy; cell death

Retinal Pigment Epithelium Dysfunction in Retinal Disorders: Pathophysiology and Therapeutic Strategies

edited by

Deepthi Rajendran Nair

and Sushma Kalmodia

submission deadline 15 Mar 2026 | Viewed by 116 | Submission Open

Keywords: retinal pigment epithelium (RPE); inherited retinal disease; RPE dysfunction

(This special issue belongs to the Section Tissues and Organs)

Brain Injury: Traumatic and Non-Traumatic Pathophysiology, Translational Approaches and Novel Treatment Strategies

edited by Thomas Kapapa,

Hayrettin Tumani

and Andreas Pfnür

submission deadline 15 Mar 2026 | Viewed by 99 | Submission Open

Keywords: traumatic brain injury; stroke; blood– brain barrier; neuroinflammation; neuroimmunology

(This special issue belongs to the Section Tissues and Organs)

Molecular Pathogenesis and Therapeutic Breakthroughs in Cutaneous Malignancies: From Melanoma to Lymphoma

edited by

Dinesh Pradhan

submission deadline 15 Mar 2026 | Viewed by 96 | Submission Open

Keywords: skin cancer; melanoma; Merkel cell carcinoma; skin lymphoma; squamous cell carcinoma; Mycosis fungoides; adnexal tumors; Sebaceous carcinoma; cutaneous soft tissue tumors

Molecular Mechanisms and Therapeutic Strategies of Macular Degeneration

edited by

Sankarathi Balaiya

submission deadline 19 Mar 2026 | Viewed by 52 | Submission Open

Keywords: macular degeneration; RPE; sirtuin; HDAC; oxidative stress; antioxidant; drusen; lipofuscin

Primary and Continued Cell Cultures

edited by

Xuefeng Liu

submission deadline 20 Mar 2026 | 5 articles | Viewed by 49141 | Submission Open

Keywords: primary normal cells; primary tumor cells; patient-derived cells; CRC (conditionally reprogrammed cells); organoids; circulating tumor cells; human diseases; toxicity; cancer models; drug discovery

(This special issue belongs to the Section Cell Methods)

Organoids as an Experimental Tool

edited by

Ralf Weiskirchen

Leo A. Van Grunsven

and Anjali A. J. Roeth

submission deadline 20 Mar 2026 | 10 articles | Viewed by 34306 | Submission Open

Keywords: organoid culture models; primary cell and cancer spheroid models; organotypic models; organoid research for animal replacement (3R); chip-based methods; general 3D cell culture protocols; in silico approaches; microinjection apical-out organoids; organoid manipulation techniques; organoid intelligence; organoids in diagnostics; imaging in organoids

(This special issue belongs to the Section Tissues and Organs)

Molecular Mechanisms of Autism Spectrum Disorder

edited by Tanya Gandhi and

Charles Lee

submission deadline 20 Mar 2026 | 8 articles | Viewed by 27303 | Submission Open

Keywords: autism spectrum disorder; neurodevelopmental disorders; molecular mechanisms; cellular-molecular mechanisms; neurobiological mechanisms; neural mechanisms; intervention approaches; treatment strategies

(This special issue belongs to the Section Cells of the Nervous System)

The Role of Cellular Senescence in Health, Disease, and Aging

edited by

Yasumichi Inoue

submission deadline 20 Mar 2026 | 9 articles | Viewed by 27153 | Submission Open

Keywords: apoptosis; cancer; cell cycle; DNA damage; metabolic diseases; oxidative stress; senolysis; senescence; therapeutic approach

(This special issue belongs to the Section Cellular Aging)

Highlights in Red Blood Cell Research

edited by

Anna Bogdanova

and

Lars Kaestner

submission deadline 20 Mar 2026 | 5 articles | Viewed by 24684 | Submission Open

Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling

New Advances and Perspectives in Nanotechnology for the Treatment of Cancer Cells

edited by

Karuppusamy Shanmugapriya

submission deadline 20 Mar 2026 | 8 articles | Viewed by 23619 | Submission Open

Keywords: nanotechnology; immunotherapeutics; cancer biotherapeutics; proliferation; regulating factors; cell culture; biomedical application; nutraceuticals; cancer treatment

(This special issue belongs to the Section Cell Methods)

Insight into Cardiomyopathy

edited by Sobuj Mia

submission deadline 20 Mar 2026 | 1 articles | Viewed by 17654 | Submission Open

Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

Advances and Breakthroughs in Stem Cell Research

edited by

Alexander E. Kalyuzhny

and

Hemant Kumar Mishra

submission deadline 20 Mar 2026 | 5 articles | Viewed by 12065 | Submission Open

Keywords: stem cell; induced pluripotent stem cell; iPSC; hematopoietic stem cell

(This special issue belongs to the Section Stem Cells)

New Concepts Relating Mesenchymal Tumors Based on Genetics and Epigenetics

edited by

Uta Flucke

submission deadline 20 Mar 2026 | 4 articles | Viewed by 10178 | Submission Open

Keywords: mesenchymal tumors; soft tissue; sarcoma; genetics; epigenetics

(This special issue belongs to the Section Cell Microenvironment)

The Role of Cilia in Health and Diseases—2nd Edition

edited by Rim Hjeij

submission deadline 20 Mar 2026 | 5 articles | Viewed by 8779 | Submission Open

Keywords: motile cilia; motile ciliopathy; Primary Ciliary Dyskinesia; genetic screening; bronchiectasis; hydrocephalus; laterality defects; infertility; gene therapy

Non-Traditional Roles of Protein Ubiquitination in Cellular Processes and Health

edited by

Chuanjin Wu

submission deadline 20 Mar 2026 | 2 articles | Viewed by 4500 | Submission Open

Keywords: Protein Ubiquitination; ; Ubiquitin chain; ; k63-linked ubiquitination; ; linear ubiquitination; ; ubiquitin-binding proteins; ; deubiquitinases; ; NF-kB; ; autophagy; ; inflammation; ; immunodeficiency; ; neurodegenerative diseases.

(This special issue belongs to the Section Cellular Pathology)

Targeting Tumor Microenvironments for Enhanced Cancer Immunotherapy

edited by

Xin Lu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 3589 | Submission Open

Keywords: tumor microenvironment; cancer immunotherapy; immune modulation; immunosuppressive mechanisms; combination therapies

(This special issue belongs to the Section Cell Microenvironment)

Human Immunodeficiency Virus/Simian Immunodeficiency Virus and Host Interactions

edited by

Nongthombam Boby

and Susanta Pahari

submission deadline 20 Mar 2026 | 2 articles | Viewed by 2113 | Submission Open

Keywords: HIV/SIV/SHIV infection; rhesus macaques; host immunity; chronic inflammation; mucosal immunity; immune evasion; therapeutic intervention; immune checkpoints; microbiota; substance use

(This special issue belongs to the Section Cellular Immunology)

Immune Response in HIV Infection, Pathogenesis and Persistence

edited by Suvadip Mallick

submission deadline 20 Mar 2026 | 2 articles | Viewed by 1861 | Submission Open

Keywords: HIV infection; immune response; chronic inflammation; immune activation; antiretroviral therapy (ART); immune reconstitution; immune checkpoints

(This special issue belongs to the Section Cellular Immunology)

Protein Misfolding and Aggregation: From Molecular Mechanisms to Human Diseases

edited by Xinrui Gui and Jinjun Wu

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1675 | Submission Open

Keywords: protein aggregation; amyloid fibrils; protein quality control; neurodegenerative diseases

(This special issue belongs to the Section Cellular Biophysics)

Targeting Cellular Microenvironment in Aging and Disease

edited by

Alexander Dityatev

and Egor Dzyubenko

submission deadline 20 Mar 2026 | 1 articles | Viewed by 1666 | Submission Open

Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM

(This special issue belongs to the Section Cellular Aging)

Cell Biology: The State of the Art and Perspectives in Japan 2025

edited by

Yasumichi Inoue

submission deadline 20 Mar 2026 | Viewed by 761 | Submission Open

Keywords: cell biology; physiology; molecular biology

Cancer Cell Signaling, Autophagy and Tumorigenesis

edited by Debanjan Bhattacharya

submission deadline 20 Mar 2026 | Viewed by 258 | Submission Open

Keywords: cancer cell signaling; autophagy; tumorigenesis; PI3K/AKT/mTOR pathway; Ras/Raf/MEK/ERK (MAPK) pathway

Chronic Obstructive Pulmonary Disease (COPD): From Molecular and Cellular Mechanisms to Therapeutic Opportunities

edited by

Renat Shaykhiev

, Bradley W. Richmond and

Umadevi Sajjan

submission deadline 20 Mar 2026 | Viewed by 195 | Submission Open

Keywords: chronic obstructive pulmonary disease (COPD); small airway disease; vascular remodeling; emphysema

(This special issue belongs to the Section Cellular Immunology)

Cell and Molecular Mechanisms of Cytogenesis

edited by

Luisa Alexandra Meireles Pinto

and

Teresa Correia Soares Canedo Calado

submission deadline 20 Mar 2026 | Viewed by 173 | Submission Open

Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders

Cellular and Molecular Mechanisms of Neurotoxicity

edited by

Anna Andrioli

Idris Azeez

, Tiziana Cotrufo and

Olumayowa Igado

submission deadline 20 Mar 2026 | Viewed by 123 | Submission Open

Keywords: neurotoxicity; neurodegeneration; neuronal cell death; neurodegenerative disorders; nerve regeneration; heavy metals; air pollution; endogenous neurotoxins; oxidative stress; glutamate

Novel Insights into Endothelial Cells in Vascular Disease

edited by

LI Zhang

submission deadline 20 Mar 2026 | Viewed by 122 | Submission Open

Keywords: endothelial cells; vascular diseases; vascular signaling

Novel Immunotherapies for Diffuse Large B-Cell Lymphoma

edited by

Waseem Lone

submission deadline 20 Mar 2026 | Viewed by 83 | Submission Open

Keywords: diffuse large B-cell lymphoma; immunotherapy; CAR-T cells; bispecific antibodies; immune checkpoint inhibitors; antibody– drug conjugates; tumor microenvironment; biomarkers; translational research

Lipid Homeostasis: Mechanisms, Regulation, and Implications for Health and Disease

edited by

Roger Schneiter

and Museer Ahmad Lone

submission deadline 25 Mar 2026 | 3 articles | Viewed by 4933 | Submission Open

Keywords: lipid metabolism; lipid synthesis and degradation; triglyceride storage; fatty acid oxidation; cholesterol homeostasis; adipogenesis; lipid droplets; lipid signaling pathways; lipid transport proteins; phospholipid balance; sphingolipid metabolism; sterol regulatory element-binding proteins (SREBPs); AMP-activated protein kinase (AMPK); peroxisome proliferator-activated receptors (PPARs); insulin signaling and lipid storage; endoplasmic reticulum stress and lipids; lipoprotein metabolism; non-alcoholic fatty liver disease (NAFLD); lipidomics; autophagy and lipid recycling; lysosomal lipid degradation; lipid-binding proteins; oxidized lipids; lipid imbalance and disease; energy homeostasis and lipid storage; lipid transport vesicles; membrane lipid composition; lipid peroxidation; lipid-related genetic disorders; nutrient sensing and lipid regulation

(This special issue belongs to the Section Cellular Biophysics)

The Silent Regulators: Non-Coding RNAs in Cell Function and Disease

edited by

Christiane Branlant

and

Mirolyuba Simeonova Ilieva

submission deadline 25 Mar 2026 | 3 articles | Viewed by 2457 | Submission Open

Keywords: non-coding RNAs; microRNAs; long non-coding RNAs (lncRNAs); regulatory RNAs; RNA interference; epigenetic regulation; RNA editing; cellular signaling; disease biomarkers; RNA therapeutics

(This special issue belongs to the Section Cell and Gene Therapy)

Displaying special issue 301-350 on page 7 of 13.

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