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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biomarkers for Gynecological Cancers submission deadline 31 Mar 2026 | 6 articles | Viewed by 10706 | Submission Open
Keywords: biomarkers; cervical; ovarian; uterine; endometrial; vaginal; vulvar; fallopian tube
(This special issue belongs to the Section Cancer Biomarkers)
Gastric Cancer Surgery: Gastrectomy, Risk, and Related Prognosis submission deadline 31 Mar 2026 | 5 articles | Viewed by 10190 | Submission Open
Keywords: gastric cancer; surgical treatment; gastrectomy; outcome; minimally invasive surgical
(This special issue belongs to the Section Clinical Research of Cancer)
Cardio-Oncology: An Emerging Paradigm in Modern Medicine: 2nd Edition
edited by Rohit Moudgil
submission deadline 31 Mar 2026 | 6 articles | Viewed by 8856 | Submission Open
Keywords: cardio-oncology; CTRCD; arrhythmias; anthracyclines; anti-her2 therapies; immune checkpoint inhibitors; artificial intelligence; guidelines; emerging research
(This special issue belongs to the Section Cancer Therapy)
Advances in Pathology of Lymphoma and Leukemia
edited by
submission deadline 31 Mar 2026 | 6 articles | Viewed by 7653 | Submission Open
Keywords: leukemia; lymphoma; immunohistochemical stains; next-generation sequencing; cytogenetics; flow cytometry analysis
(This special issue belongs to the Section Cancer Pathophysiology)
Colorectal Cancer Liver Metastases submission deadline 31 Mar 2026 | 2 articles | Viewed by 6315 | Submission Open
Keywords: liver metastases; colorectal cancer; treatment; imaging; oncologic strategy
(This special issue belongs to the Section Cancer Metastasis)
Advancements in Treatment Approaches for AML submission deadline 31 Mar 2026 | 3 articles | Viewed by 6108 | Submission Open
Keywords: AML treatment; allogeneic HSCT; novel targeted therapeutic agents; diagnostic; treatment strategies
(This special issue belongs to the Section Methods and Technologies Development)
Current Use of Hematopoietic Cell Transplantation in Hematologic Malignancies
edited by Marina Díaz-Beyá and Maria Queralt Salas
submission deadline 31 Mar 2026 | 4 articles | Viewed by 6048 | Submission Open
Keywords: allogeneic hematopoietic cell transplantation; hematologic malignancies; minimal residual disease; patient selection; conditioning regimens; graft-versus-host disease prophylaxis; immunotherapy; targeted treatments; real-world data; acute myeloid leukemia; myelodysplastic syndrome; chronic myelomonocytic leukemia; allogeneic hematopoietic cell transplantation
(This special issue belongs to the Section Transplant Oncology)
Advances in Renal Cell Carcinoma
edited by Philipp Ivanyi and Hendrik Eggers
submission deadline 31 Mar 2026 | 3 articles | Viewed by 5294 | Submission Open
Keywords: renal cell carcinoma; treatment; metastatic; prediction; medical treatment; immunotherapy; multimodal therapy; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Immunotherapy in Urothelial Carcinoma
edited by
submission deadline 31 Mar 2026 | 2 articles | Viewed by 5162 | Submission Open
Keywords: bladder cancer; upper tract urothelial carcinoma; immune checkpoint inhibitors; tumor microenvironment; biomarkers for immunotherapy; combination therapy; neo-adjuvant/adjuvant immunotherapy; resistance mechanisms; novel immunotherapeutic approaches; personalized medicine
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Oral Microbiome and Its Link to Oral Cancer: Exploring the Role of Infectious Agents
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 4363 | Submission Open
Keywords: oral microbiome; oral cancer; infectious agents; microbial dysbiosis; host– microbe interactions
(This special issue belongs to the Section Infectious Agents and Cancer)
Significance of KRAS Gene Mutations in Colorectal Cancer (2nd Edition) submission deadline 31 Mar 2026 | 2 articles | Viewed by 4313 | Submission Open
Keywords: KRAS; colorectal cancer; target therapy; mechanism; treatment targets
(This special issue belongs to the Section Molecular Cancer Biology)
The EGFR-Tyrosine Kinase Inhibitors (EGFR-TKIs) and Immune Checkpoint Inhibitors (ICIs) for Non-Small Cell Lung Cancer submission deadline 31 Mar 2026 | 2 articles | Viewed by 3673 | Submission Open
Keywords: non-small cell lung cancer; target therapy; EGFR-tyrosine kinase inhibitors; immunotherapy; immune checkpoint inhibitors; molecular analysis; surgery; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Treatment Options and Risk Factors of Pancreatic Neuroendocrine Neoplasms
edited by Anna Caterina Milanetto and
submission deadline 31 Mar 2026 | 3 articles | Viewed by 3586 | Submission Open
Keywords: pancreatic neuroendocrine neoplasms; CT scan; MRI; PET/CT; target therapy; radioligand therapy; chemotherapy; microwave ablation; radiofrequency ultrasound ablation; hepatic arterial embolization
(This special issue belongs to the Section Cancer Therapy)
Intratumoral Heterogeneity in Brain Cancers
edited by Michael Oldham
submission deadline 31 Mar 2026 | 1 articles | Viewed by 3146 | Submission Open
Keywords: intratumoral heterogeneity; brain; clonal evolution; tumor microenvironment; multiomics
(This special issue belongs to the Section Molecular Cancer Biology)
Development of Biomarkers and Antineoplastic Drugs in Solid Tumors
edited by , Sofia Verkhovskaia and Michela Roberto
submission deadline 31 Mar 2026 | 3 articles | Viewed by 3004 | Submission Open
Keywords: solid tumors; drugs; biomarkers; immunotherapy; targeted therapy; artificial intelligence
(This special issue belongs to the Section Cancer Drug Development)
Cancer Drug Discovery and Development: 2nd Edition
edited by Gary Piazza
submission deadline 31 Mar 2026 | 2 articles | Viewed by 2869 | Submission Open
Keywords: signal transduction inhibitors; small-molecule inhibitors; antibodies; PROTOC; immunotherapy; medicinal chemistry; chemical optimization; high-throughput screening
(This special issue belongs to the Section Cancer Drug Development)
Cellular and Molecular Mechanisms of Malignant Nervous System Cancers
edited by
submission deadline 31 Mar 2026 | 3 articles | Viewed by 2511 | Submission Open
Keywords: medulloblastoma; pediatric glioma; neuroblastoma; diagnosis and prognostic markers; IDH; TERT; and EGFR mutations; DNA methylation; treatment approaches and strategies (chemotherapy; radiation therapy; immunotherapy; and targeted therapy); resistance mechanisms; tumor microenvironment; molecular characteristics of tumor heterogeneity
(This special issue belongs to the Section Molecular Cancer Biology)
Minimally Invasive Therapies in Urologic Cancers
edited by Eric M. Walser and
submission deadline 31 Mar 2026 | 2 articles | Viewed by 2282 | Submission Open
Keywords: laparoscopic surgery; robotic-assisted surgery; ablation; high-intensity focused ultrasound; partial nephrectomy; minimally invasive procedures; urologic cancers
(This special issue belongs to the Section Methods and Technologies Development)
Neoadjuvant Chemoradiotherapy for Gastrointestinal Cancer
edited by Daniel Martin
submission deadline 31 Mar 2026 | 1 articles | Viewed by 2058 | Submission Open
Keywords: gastrointestinal cancers; neoadjuvant chemoradiotherapy; rectal cancer; esophageal cancer; pancreatic cancer; gastric cancer; immunotherapy; precision medicine; image guided radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Multiple Myeloma: Diagnosis and Therapy submission deadline 31 Mar 2026 | 2 articles | Viewed by 1949 | Submission Open
Keywords: multiple myeloma; plasma cell disorders; relapsed and refractory multiple myeloma; blood and marrow transplant
(This special issue belongs to the Section Cancer Therapy)
The Role of Viruses in the Development of Cancer
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1924 | Submission Open
Keywords: DNA and RNA tumour viruses; HPV; EBV; KSHV; HCV; HBV; HTLV1; McPyV
(This special issue belongs to the Section Infectious Agents and Cancer)
Exercise Interventions for People Living with Cancer: Advances in Knowledge and Implementation
edited by and Chris Swain
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1541 | Submission Open
Keywords: cancer; survivorship; exercise; physical activity; implementation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Development of Immunotherapies to Treat Lymphoma submission deadline 31 Mar 2026 | 1 articles | Viewed by 1299 | Submission Open
Keywords: lymphoma immunotherapy; CAR T-cell therapy; immune checkpoint inhibitors; monoclonal antibodies; personalized immunotherapy
Genetic Alterations and the Tumor Microenvironment
edited by Shanye Yin
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1247 | Submission Open
Keywords: tumor microenvironment; cancer immunology; immune checkpoint blockade; somatic mutations; T cell signaling; immune evasion; macrophage polarization; cancer immunotherapy resistance; single-cell transcriptomics; spatial analysis
(This special issue belongs to the Section Tumor Microenvironment)
Robotic and Thoracoscopic Surgery for Thoracic Oncology
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 1151 | Submission Open
Keywords: robotic-assisted thoracic surgery; video-assisted thoracoscopic surgery (VATS); lung cancer surgery; esophageal cancer; thymic tumors; minimally invasive surgery; pleural tumors; chest wall tumors; mediastinal surgery; thoracic oncology
(This special issue belongs to the Section Clinical Research of Cancer)
Novel Strategies to Fight Metastatic Breast Cancer
edited by and
submission deadline 31 Mar 2026 | 1 articles | Viewed by 850 | Submission Open
Keywords: breast cancer; metastasis; targeted therapy; biomarkers; personalized medicine; prognosis
(This special issue belongs to the Section Molecular Cancer Biology)
Deep Learning and Radiomics for Cancer Diagnosis, Staging, and Treatment Response
edited by Mohamed Shehata, , and Hanaa ZainEldin
submission deadline 31 Mar 2026 | 1 articles | Viewed by 688 | Submission Open
Keywords: radiomics; deep learning; cancer imaging; diagnosis; staging; treatment response; machine learning; medical image analysis; precision oncology; federated learning; AI in healthcare
(This special issue belongs to the Section Methods and Technologies Development)
Diagnosis and Therapy in Urothelial Cancer
edited by
submission deadline 31 Mar 2026 | 1 articles | Viewed by 667 | Submission Open
Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma
(This special issue belongs to the Section Cancer Therapy)
Modern Pathology, Artificial Intelligence and Personalized Therapy in Gastrointestinal Cancer
edited by Wenqing Cao
submission deadline 31 Mar 2026 | 1 articles | Viewed by 612 | Submission Open
Keywords: molecular pathology; biomarkers; digital pathology; targeted therapy; gastric cancer; colon; liver; pancreas
(This special issue belongs to the Section Cancer Therapy)
Advances in the Management and Prognosis of Brain Metastases submission deadline 31 Mar 2026 | Viewed by 472 | Submission Open
Keywords: immunotherapy; target therapy; stereotactic radiotherapy; prognosis; quality of life
(This special issue belongs to the Section Cancer Therapy)
Advances on Imaging and Treatment of Head and Neck Cancer
edited by Yading Yuan, Vishruta A. Dumane, and Luqman Dad
submission deadline 31 Mar 2026 | Viewed by 438 | Submission Open
Keywords: head and neck cancer; medical imaging; robotic surgery; image-guided radiation therapy; proton radiotherapy; online adaptive radiotherapy; artificial intelligence; machine learning
(This special issue belongs to the Section Cancer Therapy)
State of the Art and Advances in Kaposi Sarcoma
edited by
submission deadline 31 Mar 2026 | Viewed by 348 | Submission Open
Keywords: Kaposi sarcoma; human herpes virus 8 (HHV-8); oncogenesis; chemotherapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Contemporary Lung Cancer Nodal Staging and Evolving Therapeutic Paradigms
edited by and George A. Eapen
submission deadline 31 Mar 2026 | Viewed by 338 | Submission Open
Keywords: ninth TNM classification; nodal staging; endoscopic/endobronchial ultrasound; neoadjuvant/adjuvant therapy; biomarker testing
(This special issue belongs to the Section Cancer Therapy)
Glioblastoma Stem Cells: Molecule Pathways and Cancer Therapy
edited by Shilpi Singh
submission deadline 31 Mar 2026 | Viewed by 324 | Submission Open
Keywords: glioblastoma; glioma stem cells; therapeutic resistance; tumor recurrence; tumor microenvironment; cellular and molecular pathways
(This special issue belongs to the Section Molecular Cancer Biology)
TGF-β Signaling in the Tumor Microenvironment: Dual Roles in Cancer Progression and Therapy
edited by
submission deadline 31 Mar 2026 | Viewed by 233 | Submission Open
Keywords: TGF-β signaling; tumor microenvironment; solid tumors; hematologic malignancies; immune modulation; therapeutic resistance; TGF-β pathway inhibitors; cancer immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
Imaging and Liquid Biopsy Biomarkers for Cancer Diagnosis and Treatment (2nd Edition) submission deadline 31 Mar 2026 | Viewed by 232 | Submission Open
Keywords: cancer imaging; liquid biopsy; cancer diagnosis; treatment response; prognosis; metastasis; circulating tumor cells; disseminated tumor cells; circulating tumor DNA; circulating tumor RNA
(This special issue belongs to the Section Methods and Technologies Development)
miRNAs in Targeted Cancer Therapy
edited by Mustafa Özen
submission deadline 31 Mar 2026 | Viewed by 228 | Submission Open
Keywords: miRNA; micro-RNA; targeted therapy; cancer treatment; solid tumors; hematological malignancies; non-coding RNAs; epigenetic regulation; cancer therapeutics; gene therapy
(This special issue belongs to the Section Cancer Therapy)
Pioneering Advances in Neurosurgical Oncology: From Innovative Techniques to Better Patient Outcomes submission deadline 31 Mar 2026 | Viewed by 223 | Submission Open
Keywords: endoscope; 3D exoscope; tractography MRI; molecular biomarkers; stem cells; transoral; cordomas; skullbase
(This special issue belongs to the Section Methods and Technologies Development)
Immune Landscape of Multiple Myeloma
edited by Muhamed Baljevic and
submission deadline 31 Mar 2026 | Viewed by 218 | Submission Open
Keywords: myeloma; immune; T cells; therapy; fitness
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Flow Cytometry and Beyond: Innovative Cytometric Approaches in Cancer Detection, Profiling, and Therapeutic Monitoring
edited by , , Lefkothea Dova and Savvas Dimitriadis
submission deadline 31 Mar 2026 | Viewed by 214 | Submission Open
Keywords: cancer diagnostics; next-generation flow cytometry; AI-driven cytometry; high-dimensional single-cell analysis; cancer immunophenotyping; cytometry-based biomarkers; tumor heterogeneity; extracellular vesicles; spectral and mass cytometry; intraoperative flow cytometry
(This special issue belongs to the Section Methods and Technologies Development)
Proteomics in Skin Cancer: Recent Advances
edited by and Beatrice Dyring-Andersen
submission deadline 31 Mar 2026 | Viewed by 201 | Submission Open
Keywords: proteomics; skin cancer; mass spectrometry; melanoma; non-melanoma skin cancers; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia (2nd Edition)
edited by , Konstantinos Liapis and
submission deadline 31 Mar 2026 | Viewed by 178 | Submission Open
Keywords: myelodysplastic syndrome; acute myeloid leukemia; bone marrow micro-environment; targeted therapies; hematopoietic stem cell; leukemic stem cell; hematopoietic stem cell transplantation
(This special issue belongs to the Section Cancer Therapy)
Mitochondrial Metabolism in Cancer Immune Responses
edited by and Kiwon Lee
submission deadline 31 Mar 2026 | Viewed by 177 | Submission Open
Keywords: mitochondria; cancer metabolism; immune response; tumor microenvironment (TME); immunometabolism; mitochondrial reprogramming; reactive oxygen species (ROS); cancer immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Quantitative Imaging, AI, and Novel Imaging Techniques for Precision Radiology in Prostate Cancer
edited by Rulon R. Mayer, and
submission deadline 31 Mar 2026 | Viewed by 168 | Submission Open
Keywords: prostate cancer; multi-parametric MRI (mpMRI); bi-parametric MRI; positron emission tomography (PET); computed tomography (CT); ultrasound (US); artificial intelligence (AI); convolutional neural network; visual language model; computer-aided diagnosis; spatially registered multi-parametric MRI; prostate specific membrane antigen in PET/CT
(This special issue belongs to the Section Methods and Technologies Development)
Proteomic and Oncogenic Biomarkers in Gastrointestinal Cancer submission deadline 31 Mar 2026 | Viewed by 160 | Submission Open
Keywords: tumor biomarkers; early detection; tumor progression; carcinogenesis; inflammatory mediators; gastrointestinal cancer; prognostic biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Screening and Surveillance of Gastrointestinal and Pancreatic Cancers
edited by Darina Kohoutová and
submission deadline 31 Mar 2026 | Viewed by 155 | Submission Open
Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Mastering the Immunosuppressive Tumor Microenvironment with Cancer Vaccines submission deadline 31 Mar 2026 | Viewed by 151 | Submission Open
Keywords: tumor microenvironment; cancer vaccines; immunosuppression; immune modulation; checkpoint inhibitors; dendritic cell vaccines; T cell activation; personalized cancer immunotherapy; vaccine adjuvants; combination immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
Lipids and Small Metabolites in Cancer—2nd Edition
edited by and
submission deadline 31 Mar 2026 | Viewed by 137 | Submission Open
Keywords: lipid; small metabolites; cancer; metabolome- and lipidome-related mechanisms; amino acids; fatty acids; numerous components of biochemical pathways
(This special issue belongs to the Section Molecular Cancer Biology)
Real-World Clinical Studies in Acute Leukemia
edited by
submission deadline 31 Mar 2026 | Viewed by 136 | Submission Open
Keywords: acute myeloid leukemia (AML); acute lymphoid leukemia (ALL); refractory/relapsed leukemia; target therapy; FLT3 inhibitors; IDH (1-2) inhibitors; venetoclax; hypomethylating agents; stem cell transplantation (SCT); minimal residual disease (MRD); MRD-driven therapy
(This special issue belongs to the Section Clinical Research of Cancer)
World Lung Cancer Awareness Month: 2nd Edition
edited by
submission deadline 31 Mar 2026 | Viewed by 132 | Submission Open
Keywords: lung cancer; tumor microenvironment; early detection; therapeutic targets; new therapeutic strategies; surgery; genetics
(This special issue belongs to the Section Cancer Therapy)
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