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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications

edited by

Spiros Vlahopoulos

submission deadline 30 Sep 2026 | Viewed by 336 | Submission Open

Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma

(This special issue belongs to the Section Tumor Microenvironment)

Health-Related Quality of Life in Cancer Survivorship

edited by Deniz Gencer and Elisabeth Coyne

submission deadline 30 Sep 2026 | Viewed by 329 | Submission Open

Keywords: cancer survivorship; health-related quality of life (HRQoL); interventions; psychological support; personalized care; educational resources

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Medical Image-Based Cervical Cancer Prevention, Diagnosis, and Treatment

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 30 Sep 2026 | Viewed by 323 | Submission Open

Keywords: medical imaging; 3-dimensional imaging; cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Beyond PEGylation: Next-Generation Nanomedicine for Cancer Therapy

edited by

Soumen Saha

submission deadline 30 Sep 2026 | Viewed by 305 | Submission Open

Keywords: nanomedicine; tumor-targeting mechanisms; cancers

(This special issue belongs to the Section Tumor Microenvironment)

Redefining Precision Radiotherapy

edited by Srinivasan Vijayakumar

submission deadline 30 Sep 2026 | Viewed by 302 | Submission Open

Keywords: precision radiotherapy; cancer radiotherapy; PRT; RadioTheronostics

(This special issue belongs to the Section Methods and Technologies Development)

Current Status of Neuroendocrine Tumors with a Special Focus on Diagnosis and Novel Treatments—3rd Edition

edited by

Dan Granberg

submission deadline 30 Sep 2026 | Viewed by 292 | Submission Open

Keywords: neuroendocrine tumors; somatostatin analogues; PRRT; chemotherapy; 68Gallium-DOTATOC; PET; CT; targeted therapies; mTOR; inhibitors; angiogenesis

(This special issue belongs to the Section Cancer Therapy)

Advances in Combination Therapy for Lymphoma

edited by

Maria Christina Cox

submission deadline 30 Sep 2026 | Viewed by 283 | Submission Open

Keywords: lymphoma; combination therapies; T-cell engagers; immuno-conjugates; targeted drugs

(This special issue belongs to the Section Cancer Therapy)

Targeting JAK/STAT Signaling Pathways for Studying Cancer Pathogenesis, Discovering Cancer Markers, Developing Therapies, and Bypassing Drug Resistance

edited by

Xiaonan Han

submission deadline 30 Sep 2026 | Viewed by 281 | Submission Open

Keywords: JAK-STAT; cancer markers; drug resistance; tumoroids; CAR T-cell therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Clinical Trials and Precision Medicine for Neuro-Oncology

edited by Malaka Ameratunga

submission deadline 30 Sep 2026 | Viewed by 264 | Submission Open

Keywords: clinical trials; neuro-oncology; precision oncology; molecular targets; precision medicine

(This special issue belongs to the Section Clinical Research of Cancer)

Skin Cancer and Environmental Exposure: Unveiling Latest Insights and Future Directions

edited by

Dimitra Koumaki

submission deadline 30 Sep 2026 | Viewed by 261 | Submission Open

Keywords: skin cancer; melanoma; non-melanoma skin cancer; environmental factors; ultraviolet (UV) radiation; DNA damage; etiology; prevention and treatment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

CRLM in the Era of Transplant Oncology: New Hope, New Questions

edited by Brian Davidson and

Khurum Khan

submission deadline 30 Sep 2026 | Viewed by 259 | Submission Open

Keywords: colorectal cancer; liver transplant; transplant oncology; chemotherapy; immunotherapy; immunosuppression; genetic profiling; circulating ccDNA; staging; surveillance

(This special issue belongs to the Section Cancer Therapy)

New Era of Systemic Therapy for Different Types of Skin Cancer

edited by Magdalena Ciazynska

submission deadline 30 Sep 2026 | Viewed by 252 | Submission Open

Keywords: skin cancer systemic therapy; immunotherapy in skin cancer; targeted therapy in skin malignancies; melanoma and nonmelanoma skin cancer; biomarkers and treatment response; resistance mechanisms; combination therapy; real worldreal-world outcomes; novel therapeutic agents; precision oncology

(This special issue belongs to the Section Cancer Therapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor: 2nd Edition

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Sep 2026 | Viewed by 250 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Next-Generation Cancer Research: AI Approaches for Biomarkers, Therapeutics and Beyond

edited by Wen Zhang

submission deadline 30 Sep 2026 | Viewed by 243 | Submission Open

Keywords: computational genetics; cancer; big data analysis; deep learning; statistical modeling; bioinformatics; AI; biomarkers; therapeutics

(This special issue belongs to the Section Cancer Informatics and Big Data)

PSMA Targeted Strategies and Radioligand Therapies in Prostate Cancer: From Preclinical Models to Clinical Translation

edited by Neha Vapiwala and John Nikitas

submission deadline 30 Sep 2026 | Viewed by 238 | Submission Open

Keywords: prostate cancer; prostate-specific membrane antigen; radioligand therapy; radiopharmaceutical therapy; radiotherapy; theranostics

(This special issue belongs to the Section Cancer Therapy)

Non-Melanoma Skin Cancer: A Growing Problem in the Elderly Population

edited by Jolanta Jaworek and Dariusz Kowalczyk

submission deadline 30 Sep 2026 | Viewed by 236 | Submission Open

Keywords: NMSC; pathomechanism of NMSC; NMSC and gut and/or skin microbiota; NMSC treatment; NMSC diagnosis

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Non-Coding RNAs in Cancer: Molecular Diagnostics and RNA-Based Therapeutics

edited by

Andreas Scorilas

and

Marios A. Diamantopoulos

submission deadline 30 Sep 2026 | Viewed by 232 | Submission Open

Keywords: ncRNAs; miRNAs; lncRNAs; snoRNAs; regulatory RNAs; housekeeping RNAs; cancer biomarkers; RNA-targeted approaches; predictive markers; therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Biomarkers in the Management of Gynecological Cancer

edited by Ferenc Bánhidy,

Keszthelyi Márton

and Balázs Lintner

submission deadline 30 Sep 2026 | Viewed by 231 | Submission Open

Keywords: gynecologic cancer; biomarkers; cervical cancer; endometrial cancer; ovarian cancer; vulvar cancer; diagnostic biomarkers; prognostic biomarkers; predictive biomarkers

(This special issue belongs to the Section Cancer Biomarkers)

Leukemia Stem Cells: Persistence, Resistance, and Novel Eradication Strategies

edited by Elisa Donato and Darja Karpova

submission deadline 30 Sep 2026 | Viewed by 230 | Submission Open

Keywords: leukemia stem cells (LSCs); acute myeloid leukemia (AML); therapeutic resistance; minimal residual disease (MRD); LSC quiescence; cellular therapy; hematopoietic stem cell transplantation (HSCT); LSC microenvironment

Roles of Circular RNAs (circRNAs) in Cancer Development and Progression

edited by

Qubo Zhu

submission deadline 30 Sep 2026 | Viewed by 227 | Submission Open

Keywords: circular RNAs (circRNAs); cancer development; tumor progression; oncogenesis; gene regulation; metastasis; tumor microenvironment; therapeutic targets; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Cancer Biology)

Advanced Multimodal Neuroimaging and Computational Approaches in Brain Tumor Research

edited by

Feng Liu

submission deadline 30 Sep 2026 | Viewed by 226 | Submission Open

Keywords: brain tumors; multimodal neuroimaging; artificial intelligence; radiomics; imaging genomics; diffusion MRI; functional MRI; precision oncology

Therapy in Neuro-Oncology

edited by

Herbert B. Newton

submission deadline 30 Sep 2026 | Viewed by 226 | Submission Open

Keywords: glioma; IDH inhibitor; CAR-T; primary CNS lymphoma; cancer neuroscience; brain metastasis; leptomeningeal disease; molecular classification; pediatric and AYA brain tumors; liquid biopsy; AI; radiation; supportive care

(This special issue belongs to the Section Cancer Therapy)

New Clinical Insights into Gynecological Malignancies

edited by

Amelia Jernigan

submission deadline 30 Sep 2026 | Viewed by 223 | Submission Open

Keywords: innovative care; data science; precision medicine; uterine cancer; ovarian cancer; vulvar cancer; vaginal cancer

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical Pharmacology in Lung Cancer—2nd Edition

edited by

Chih-Jen Yang

submission deadline 30 Sep 2026 | Viewed by 215 | Submission Open

Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS

(This special issue belongs to the Section Cancer Drug Development)

The Evolving Landscape of Endometrial Cancer

edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis

submission deadline 30 Sep 2026 | Viewed by 213 | Submission Open

Keywords: endometrial cancer; patient quality of life; fertility preservation; molecular classification; minimal invasive surgery; emerging therapeutic approaches

(This special issue belongs to the Section Molecular Cancer Biology)

Pancreatic Cancer Ultrasound: A Problem-Based Approach

edited by

Carla Serra

and Andrea Boccatonda

submission deadline 30 Sep 2026 | Viewed by 205 | Submission Open

Keywords: cancer; ultrasound; pancreas; CEUS; malignancy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Tumor Microenvironment in Hematological Malignancies: Advances in Targeted Therapies and Cellular Mechanisms

edited by Carolina Simioni

submission deadline 30 Sep 2026 | Viewed by 196 | Submission Open

Keywords: hematological malignancies; tumor microenvironment; bone marrow niche; targeted therapy; signal transduction; drug resistance; tumor metabolism; cell plasticity; biomarkers; cell–cell interactions

(This special issue belongs to the Section Tumor Microenvironment)

Improving Quality of Life for Glioma Patients: Enhancing Support Access

edited by

Adela Wu

submission deadline 30 Sep 2026 | Viewed by 189 | Submission Open

Keywords: glioma; quality of life; palliative care; supportive care; patient-centered care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advancements in Cervical Cancer Screening and HPV-Related Disease Management

edited by

Maria Lina Tornesello

submission deadline 30 Sep 2026 | Viewed by 184 | Submission Open

Keywords: cervical cancer; cervical intraepithelial neoplasia; HPV (human papillomavirus); cervical cancer screening; high-resolution colposcopy; DNA methylation; HPV genotyping; HPV vaccination; molecular diagnostics; self-sampling; biomarkers; immune response; Ai-assisted screening; cervical cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Current Treatments of Esophageal and Esophagogastric Junction Cancers (2nd Edition)

edited by

Masanobu Nakajima

submission deadline 30 Sep 2026 | Viewed by 183 | Submission Open

Keywords: esophageal cancer; esophagogastric junction cancer; endoscopic resection; surgery; minimally invasive surgery; robotic surgery; chemotherapy; chemoradiotherapy; immune checkpoint inhibitors

(This special issue belongs to the Section Cancer Therapy)

Radiation Therapy for Meningiomas

edited by Helen A. Shih and Lia M. Halasz

submission deadline 30 Sep 2026 | Viewed by 183 | Submission Open

Keywords: radiation therapy; proton radiation; particle therapy; theranostics; brachytherapy; molecular features; advance imaging; late toxicities; quality of life

(This special issue belongs to the Section Cancer Therapy)

Recent Advances in Reconstruction and Surgery for Breast Cancer

edited by

Gilles Houvenaeghel

submission deadline 30 Sep 2026 | Viewed by 182 | Submission Open

Keywords: breast cancer; reconstruction; breast surgery; axillary surgery; sentinel lymph node; neoadjuvant chemotherapy; autologous fat transfer; breast implant

Targeted Therapy for Colorectal Cancer

edited by

Rajat Bhattacharya

submission deadline 30 Sep 2026 | Viewed by 181 | Submission Open

Keywords: colorectal cancer; targeted therapy; combination therapy; novel inhibitors; immune targeting; overcoming resistance

Conventional and AI-Enabled Precision Medicine/Surgery in Oncology

edited by

Georgios Antonios Margonis

and Dimitris Bertsimas

submission deadline 30 Sep 2026 | Viewed by 180 | Submission Open

Keywords: precision medicine; precision surgery; surgical oncology; treatment effect heterogeneity; subgroup discovery; causal inference; real-world evidence; confounding; interpretable AI; clinical decision support

(This special issue belongs to the Section Cancer Informatics and Big Data)

Advances in Diagnosis and Clinical Trials of Bladder Cancer

edited by Mutsuo Furihata

submission deadline 30 Sep 2026 | Viewed by 179 | Submission Open

Keywords: bladder cancer; pathological diagnosis; tumorigenesis; 5-aminolevulinic acid; photodynamic therapies; robot-assisted radical cystectomy; fluorescence navigation; artificial intelligence

Therapy of Nasopharyngeal Carcinoma: Emphasizing Radiotherapy

edited by Yunfei Xia

submission deadline 30 Sep 2026 | Viewed by 177 | Submission Open

Keywords: nasopharyngeal carcinoma (NPC); radiotherapy; IMRT; adaptive radiotherapy; dose optimization; re-irradiation; radioresistance; radiomics; biomarkers; toxicity mitigation

(This special issue belongs to the Section Cancer Therapy)

Epigenomic and Transcriptional Mechanisms in Cancer Progression and Therapy Response

edited by Benjamin L. Kidder

submission deadline 30 Sep 2026 | Viewed by 176 | Submission Open

Keywords: cancer progression; genetic mutations; epigenomic plasticity; tumor heterogeneity; gene regulatory networks; epigenomic mechanisms

(This special issue belongs to the Section Molecular Cancer Biology)

Minimally Invasive Surgery for Gastric Cancer

edited by Steve Kwon

submission deadline 30 Sep 2026 | Viewed by 176 | Submission Open

Keywords: comparison of laparoscopic vs. robotic approaches in long-term oncological and perioperative outcomes; minimally invasive surgery vs. endoscopic resections in treatment of early gastric cancer; minimally invasive surgery vs. open approaches for advanced gastric cancer, including peritoneal carcinomatosis; the role of minimally invasive surgery in D2 lymphadenectomy; minimally invasive emergent gastrectomy for gastric cancer; minimally invasive surgery (or nonoperative management) for gastric cancer in the era of immunotherapy; learning curve of robotic gastrectomy and D2 lymphadenectomy; technical and review papers, e.g., anastomotic techniques and reconstruction methods; minimally invasive total gastrectomy; three-dimensional (3D) imaging in minimally invasive gastric cancer surgery

(This special issue belongs to the Section Methods and Technologies Development)

Strategies and Techniques in Diagnosing, Treating and Surveying Sarcoma

edited by H. Thomas Temple

submission deadline 30 Sep 2026 | Viewed by 170 | Submission Open

Keywords: sarcoma; diagnosis; therapy; treatment; surgery; molecular; radiomics

Novel Strategies for Treating Castration-Resistant Prostate Cancer

edited by

Balaji Chandrasekaran

and

Eswar Shankar

submission deadline 30 Sep 2026 | Viewed by 165 | Submission Open

Keywords: androgen receptor; CRPC; drug resistance; combination therapy; small molecules; chemoprevention

(This special issue belongs to the Section Cancer Therapy)

Precision Oncology in Urothelial Cancer: From Biomarkers to Clinical Translation

edited by Sizhi (Paul) Gao and

Jiaqian Luo

submission deadline 30 Sep 2026 | Viewed by 161 | Submission Open

Keywords: precision oncology; urothelial cancer; biomarker; novel therapies; therapy resistance; tumor heterogeneity; tumor microenvironment; real-world evidence; artificial intelligence

Metabolomics Approaches in Cancer Diagnosis

edited by

Raj Kumar Sharma

submission deadline 30 Sep 2026 | Viewed by 158 | Submission Open

Keywords: metabolomics; metabolites; NMR metabolomics; mass spectrometry in metabolomics; cancer biomarkers; metabolomics methods

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Decoding Glioblastoma: Mechanisms, Innovations, and Therapeutic Advancements

edited by

Frances Chow

, Jerica M. Lomax and Yoon Jae Choi

submission deadline 30 Sep 2026 | Viewed by 156 | Submission Open

Keywords: glioblastoma; tumor heterogeneity; resistance; glioma stem cells; multi-omics; molecular targeting; tumor microenvironment; immunotherapy; spatial transcriptomics; epigenetic regulation; metabolic reprogramming; liquid biopsy; radiomics; advanced imaging; nuclear medicine

The Central Role of CD8+ T Cells in Cancer Immunotherapy: From Functional Remodeling to Clinical Translation

edited by

Shengjun Wang

submission deadline 30 Sep 2026 | Viewed by 152 | Submission Open

Keywords: CD8+T cells; T cell exhaustiont; metabolic reprogramming; epigenetic regulation; tumor microenvironmen; immune checkpoint blockade

Treatment Response and Predictive Factors in Breast Cancer

edited by Masakazu Toi and Louis Chow

submission deadline 30 Sep 2026 | Viewed by 152 | Submission Open

Keywords: breast cancer; treatment; predictive factors; survival rate

Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma: 2nd Edition

edited by

Susana Cedrés

submission deadline 30 Sep 2026 | Viewed by 151 | Submission Open

Keywords: malignant mesothelioma; target therapy; biomarkers

Perspectives in Surgical Treatments of Gastrointestinal Cancer

edited by Jayesh Sagar

submission deadline 30 Sep 2026 | Viewed by 146 | Submission Open

Keywords: artificial intelligence; robotic surgery; GI surgery; colorectal cancer

(This special issue belongs to the Section Methods and Technologies Development)

Novel Insights into Platelet Cancer Crosstalk

edited by

Azaj Ahmed

submission deadline 30 Sep 2026 | Viewed by 146 | Submission Open

Keywords: platelet–tumor interactions; cancer-associated thrombosis; metastasis; tumor microenvironment; platelets; platelet activation; thromboinflammation; hemostasis

Advancements in Surgical and Multidisciplinary Management of Hepatopancreaticobiliary Cancer

edited by Hideki Takami

submission deadline 30 Sep 2026 | Viewed by 144 | Submission Open

Keywords: hepatopancreaticobiliary cancer; pancreatic cancer; biliary tract cancer; hepatocellular carcinoma; multidisciplinary treatment; systemic therapy; neoadjuvant therapy; conversion surgery; precision medicine

Artificial Intelligence for Multi-Modal Data Integration in Computational Oncology and Cancer Diagnosis

edited by

Qianqian Song

submission deadline 30 Sep 2026 | Viewed by 143 | Submission Open

Keywords: computational pathology; artificial intelligence; deep learning; digital pathology; multimodal data integration; biomarker discovery; cancer diagnosis; precision oncology; explainable AI; clinical translation

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Displaying special issue 451-500 on page 10 of 23.

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