The Genetics of Head and Neck Squamous Cell Carcinoma
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 58
Special Issue Editor
Interests: carcinogenesis; cancer progression; metastasis signaling; preclinical and animal models; genetic; genomic and epigenomic; target and drug discovery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Head and neck squamous cell carcinoma (HNSCC) remains a significant global health burden, with complex genetic and molecular underpinnings that continue to shape diagnostic, prognostic, and therapeutic strategies. Recent advances in genomic technologies have uncovered a vast array of genetic mutations, epigenetic alterations, and molecular pathways driving HNSCC initiation and progression. Understanding these genetic underpinnings is crucial for developing novel therapeutic strategies, improving patient stratification, and enhancing clinical outcomes. This Special Issue aims to explore the latest advancements in understanding the genetic landscape of HNSCC, highlighting innovations in genomic profiling, biomarker discovery, and precision oncology approaches. We seek to create a comprehensive collection of research that advances knowledge on the interplay between genetic alterations, tumor biology, and the tumor microenvironment, ultimately driving more effective, individualized treatment options. This Special Issue aligns with the journal’s commitment to advancing cancer research and precision medicine, ensuring a balance of foundational insights and translational applications.
We welcome submissions of original research articles, reviews, and short communications addressing key genetic insights into HNSCC development, progression, and treatment resistance. Topics may include, but are not limited to, the following:
- Genomic and transcriptomic profiling of HNSCC subtypes;
- Somatic mutations and their clinical significance;
- Epigenetic regulation and chromatin remodeling in HNSCC;
- Biomarker discovery for diagnosis, prognosis, and therapy response;
- Genetic drivers of treatment resistance;
- The role of the tumor microenvironment in genetic alterations;
- Precision medicine approaches targeting genetic vulnerabilities;
- Comparative genetics between HPV-positive and HPV-negative HNSCC;
- Liquid biopsy and circulating tumor DNA for genetic monitoring.
We look forward to your valuable contributions and collaboration in advancing this vital area of oncology research.
Best,
Dr. Sabrina Daniela da Silva
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- head and neck squamous cell carcinoma
- tumor genetics
- genomic profiling
- precision oncology
- biomarkers
- tumor microenvironment
- epigenetics
- somatic mutations
- molecular pathways
- targeted therapies
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