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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Primary Central Nervous System Lymphoma: A Challenging Disease
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3715 | Submission Open
Keywords: primary central nervous system lymphoma (PCNSL); diffuse large B cell lymphoma (DLBCL); advanced imaging; novel therapies; prognostic markers
Recent Advances in the Understanding of Myelodysplastic Syndrome and Acute Myeloid Leukemia (2nd Edition)
edited by , Konstantinos Liapis and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 3530 | Submission Open
Keywords: myelodysplastic syndrome; acute myeloid leukemia; bone marrow micro-environment; targeted therapies; hematopoietic stem cell; leukemic stem cell; hematopoietic stem cell transplantation
(This special issue belongs to the Section Cancer Therapy)
T-Cell Lymphoma: From Diagnosis to Treatment
edited by Lubomir Sokol and Yumeng Zhang
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3527 | Submission Open
Keywords: cutaneous T-cell lymphomas (CTCLs); peripheral T-cell lymphomas (PTCLs); Sezary syndrome (SS); mycosis fungoides (MF); genetic; epigenetic; therapeutic strategies
Hepatocellular Carcinoma Progression and Metastasis
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 3345 | Submission Open
Keywords: hepatocellular carcinoma; tumor progression; metastasis; liver cancer; angiogenesis; epithelial–mesenchymal transition; tumor microenvironment; molecular pathways; biomarkers; targeted therapy; systemic therapy
(This special issue belongs to the Section Cancer Metastasis)
Pathology and Treatment of Triple-Negative Breast Cancer (2nd Edition)
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 3288 | Submission Open
Keywords: triple-negative breast cancer (TNBC); molecular profiling; tumor microenvironment; targeted therapy; novel biomarkers
IBD-Associated Cancer
edited by Takayuki Ogino
submission deadline 30 Nov 2026 | 2 articles | Viewed by 3222 | Submission Open
Keywords: IBD-associated cancer; Crohn’s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Role of Human Papillomavirus (HPV) in Cancers: Epidemiology, Molecular Biology, and Advancements in Detection Methods
edited by
submission deadline 30 Nov 2026 | 3 articles | Viewed by 3109 | Submission Open
Keywords: human papillomavirus (HPV); cancer; HPV-related cancer; epidemiology; oncogenesis; molecular mechanisms; diagnostic technologies; epidemiological trends; risk factors; HPV-associated cancers; molecular pathways; cellular pathways; biomarkers; diagnostic tools; immune response; host–pathogen interaction
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Gynecological Cancers: Molecular Insights to Precision Therapy
edited by Gian Franco Zannoni and
submission deadline 30 Nov 2026 | 3 articles | Viewed by 2686 | Submission Open
Keywords: gynecological cancers; precision medicine; molecular biomarkers; targeted therapy; tumor microenvironment; immunotherapy; translational oncology
The Role of Ferroptosis in Cancer (2nd Edition)
edited by Wei Li
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2671 | Submission Open
Keywords: ferroptosis; cancer; reactive oxygen species; ROS; regulated cell death; RCD; immunogenic cell death; ICD; immunosuppression
(This special issue belongs to the Section Molecular Cancer Biology)
Innovations and Current Evidence in Radiotherapy for Urological Cancers
edited by
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2663 | Submission Open
Keywords: radiotherapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; testicular cancer; penile cancer; palliative; metastases; salvage
(This special issue belongs to the Section Cancer Therapy)
Advances in Nanoparticle and Exosome Technology for Delivery of Payloads in CNS Tumors
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 2441 | Submission Open
Keywords: glioblastoma; brain metastasis; nanoparticles; exosomes; viral therapy; delivery of payload; imaging probes
(This special issue belongs to the Section Cancer Drug Development)
Radiation Therapy for Metastatic Cancer
edited by Johnny Kao
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2294 | Submission Open
Keywords: metastasis; radiation therapy; tumor agnostic; oligometastases; survivorship; combined modality therapy
(This special issue belongs to the Section Cancer Therapy)
Clinical Treatment and Translational Advances in Myelodysplastic Syndromes and Acute Myeloid Leukemia submission deadline 30 Nov 2026 | 2 articles | Viewed by 2283 | Submission Open
Keywords: myeloid neoplasms; myelodysplastic neoplasms; acute myeloid leukemia; leukemogenesis; target therapy
Advances in Urological Cancer: Innovative Therapies and Biomarkers
edited by Hiroshi Yaegashi
submission deadline 30 Nov 2026 | 2 articles | Viewed by 2182 | Submission Open
Keywords: urological oncology; urothelial cancer; prostate cancer; renal cancer; biomarkers; immunotherapy
Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy submission deadline 30 Nov 2026 | 1 articles | Viewed by 2068 | Submission Open
Keywords: oncoproteins; targeted therapy; oncogenic signaling pathways; tumor microenvironment; oxidative stress and cancer; tumorigenesis; cancer chemoprevention
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in the Management of Pelvic Tumors: 2nd Edition
edited by Giorgia Gaia and
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1880 | Submission Open
Keywords: pelvic cancer; prostate cancer; bladder cancer; uterine cancer; ovarian cancer; rectal cancer; anal cancer
(This special issue belongs to the Section Cancer Therapy)
Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1720 | Submission Open
Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies
(This special issue belongs to the Section Clinical Research in Cancer)
Contemporary Head and Neck Oncology: Progress, Clinical Dilemmas, and Future Directions submission deadline 30 Nov 2026 | 3 articles | Viewed by 1720 | Submission Open
Keywords: head and neck oncology; clinical dilemmas; future directions; diagnosis; biological characterization; treatment strategies; recurrent/metastatic settings
(This special issue belongs to the Section Cancer Therapy)
New Clinical Insights into Gastrointestinal Cancers
edited by Dai Shida
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1627 | Submission Open
(This special issue belongs to the Section Clinical Research in Cancer)
Burkitt Lymphoma: From Pathogenesis to Current Treatments: 2nd Edition
edited by Lorenzo Leoncini and
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1625 | Submission Open
Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy
Pathology of Renal Tumors
edited by and Anna Caliò
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1617 | Submission Open
Keywords: renal cell tumors; diagnosis; prognosis; metabolomics; genomics; molecular; immunohistochemistry; histopathology
(This special issue belongs to the Section Cancer Pathophysiology)
In Vitro and In Vivo Pharmacology for Glioma Drug Discovery submission deadline 30 Nov 2026 | 1 articles | Viewed by 1427 | Submission Open
Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence
(This special issue belongs to the Section Cancer Drug Development)
Thermal Analysis and Proteomic Approaches for Biofluid Proteome Profiling in Cancer Diagnostics
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1356 | Submission Open
Keywords: thermal analysis; proteomics; thermal liquid biopsy; differential scanning calorimetry; mass spectrometry; serum proteome; clinical diagnostics; cancer diagnostics; biospecimen
(This special issue belongs to the Section Methods and Technologies Development)
Adjuvant Therapy and the Cytotoxic Effects in Colorectal Cancers
edited by William H. Gmeiner
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1341 | Submission Open
Keywords: colorectal cancer; adjuvant chemotherapy; targeted therapy; immunotherapy; metastatic colorectal cancer; drug resistance; combination therapy; cytotoxic effects
(This special issue belongs to the Section Cancer Therapy)
Tumor Microenvironment Biomarkers: Bridging Immunology and Metastasis submission deadline 30 Nov 2026 | 1 articles | Viewed by 1322 | Submission Open
Keywords: tumor microenvironment; molecular biomarkers; cancer progression; immunomodution; therapeutic targets
(This special issue belongs to the Section Cancer Biomarkers)
The Prevalence and Incidence of Different Cancers: Risk Factors, Predictions and Modelling Cancer Rates
edited by Aleksandra Izabela Czerw
submission deadline 30 Nov 2026 | 2 articles | Viewed by 1051 | Submission Open
Keywords: cancer epidemiology; prevalence modelling; incidence modelling; epidemic modelling; risk factors
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Targeted Therapy in Glioblastoma and Glioma
edited by Ben A. Strickland
submission deadline 30 Nov 2026 | 1 articles | Viewed by 1041 | Submission Open
Keywords: glioblastoma; neuro-oncology; immunotherapy; tumor microenvironment; macrophage checkpoint; complement system; sphingolipid metabolism; drug resistance; MGMT methylation; combination therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Pharmacology, Microbiology and Immunology in Cancers
edited by Mihail Virgil Boldeanu
submission deadline 30 Nov 2026 | 1 articles | Viewed by 989 | Submission Open
Keywords: cancer pharmacology; tumor immunology; cancer microbiome; immunotherapy; targeted therapy; tumor microenvironment; drug resistance; host–microbiota interactions; translational oncology; personalized cancer therapy
Signaling Pathways and Molecular Crosstalk in the Tumor Microenvironment submission deadline 30 Nov 2026 | 2 articles | Viewed by 953 | Submission Open
Keywords: tumor microenvironment (TME); signal transduction pathways; intercellular communication; cancer progression and metastasis; therapeutic targets and drug resistance
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Precision Diagnostics and Personalized Therapeutics for Prostate Cancer
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 880 | Submission Open
Keywords: diagnostics; personalized therapeutics; prostate cancer
Diet, Microbiome, and Immune Regulation in Early-Onset and Obesity-Associated Gastrointestinal Cancers: Mechanisms, Biomarkers, and Therapeutic Targets
edited by Saratchandra Khumukcham and
submission deadline 30 Nov 2026 | Viewed by 867 | Submission Open
Keywords: colorectal cancer; gastrointestinal cancer; obesity-associated cancer; diet-induced obesity; aging; intestinal epithelium; tumor microenvironment; Wnt signaling; cancer immunology; organoid models
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Recent Advances and Emerging Directions in Lung Cancer Radiotherapy
edited by Arturo Navarro-Martín
submission deadline 30 Nov 2026 | 2 articles | Viewed by 781 | Submission Open
Keywords: lung cancer; hypofractionated radiotherapy; lattice; flash therapy; protons
(This special issue belongs to the Section Cancer Therapy)
Imaging in Breast Cancer: Advancing Screening, Diagnosis, and Therapy
edited by Almir Galvão Vieira Bitencourt and Soraia Damião
submission deadline 30 Nov 2026 | 1 articles | Viewed by 656 | Submission Open
Keywords: breast neoplasms/diagnostic imaging; mammography; contrast media; magnetic resonance imaging; ultrasound; PET-CT; early detection of cancer; neoadjuvant therapy; artificial intelligence; precision medicine
Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease
edited by
submission deadline 30 Nov 2026 | Viewed by 542 | Submission Open
Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy, quality of life, and prognosis
New Insights in Urologic Oncology: Immune and Tumor Antigen Targeting Approaches
edited by Justin H. Hwang, Alex Tsai and Ali Arafa
submission deadline 30 Nov 2026 | 1 articles | Viewed by 522 | Submission Open
Keywords: urologic cancer; immune therapies; tumor antigens; tumor microenvironment; targeted therapies; therapeutic resistance; tumor heterogeneity
The Use of Artificial Intelligence in Cancer Research, Diagnosis, and Care
edited by
submission deadline 30 Nov 2026 | 1 articles | Viewed by 497 | Submission Open
Keywords: artificial intelligence; oncology; cancer diagnosis; prognostic modeling; clinical validation; digital twins
Onco-Nephrology: Managing Kidney Health in Cancer Patients
edited by Gerrit van den Berg
submission deadline 30 Nov 2026 | 1 articles | Viewed by 481 | Submission Open
Keywords: onconephrology; nephrotoxicity; acute kidney injury; chronic kidney disease; kidney health; nephrotoxin stewardship; cancer survival; personalized medicine; supportive care
Tumor Heterogeneity in Breast Cancer—the “Omics” Revolution submission deadline 30 Nov 2026 | Viewed by 469 | Submission Open
Keywords: breast cancer; tumor heterogeneity; tumor microenvironment; transcriptional regulation; single-cell RNA-seq; spatial transcriptomics; genomics; epigenomics; proteomics; metabolomics
(This special issue belongs to the Section Molecular Cancer Biology)
Role of Cytokines in Cancer (2nd Edition) submission deadline 30 Nov 2026 | Viewed by 456 | Submission Open
Keywords: inflammation; tumor microenvironment; cytokines
(This special issue belongs to the Section Tumor Microenvironment)
New Approaches to Surgical Treatment and Care for Urological Cancer
edited by and Bente Thoft Jensen
submission deadline 30 Nov 2026 | Viewed by 387 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; penile cancer; patient perspective; patient education; enhanced recovery after surgery (ERAS) protocols; prehabilitation rehabilitation; sexual health
(This special issue belongs to the Section Clinical Research in Cancer)
Cellular Senescence in Cancer: Therapeutic Induction, Microenvironmental Crosstalk and Clinical Implications submission deadline 30 Nov 2026 | Viewed by 385 | Submission Open
Keywords: therapy-induced senescence (TIS); TIS resistance; senescence-associated secretory phenotype (SASP); senescence-associated heterochromatin foci (SAHF); immune escape; immune response; immune surveillance; cancer-associated fibroblasts; tumor microenvironment; senolytic therapy; senomorphics; senomodulation; extracellular vesicles; chromatin; imprinting and epigenetic reprogramming; biomarkers
(This special issue belongs to the Section Molecular Cancer Biology)
Acute Myeloid Leukemia: Novel Therapeutic Agents and Clinical Trials
edited by Wieslaw W. Jedrzejczak
submission deadline 30 Nov 2026 | Viewed by 361 | Submission Open
Keywords: acute leukemia; targeted therapy; antibody–drug conjugates
(This special issue belongs to the Section Clinical Research in Cancer)
Intraoperative Radiotherapy in Cancer Treatment
edited by
submission deadline 30 Nov 2026 | Viewed by 360 | Submission Open
Keywords: intraoperative radiation therapy; image-guided IORT; IOERT; kV-IORT; HDR-IORT; FLASH
(This special issue belongs to the Section Cancer Therapy)
HMGA Oncoproteins in Cancer submission deadline 30 Nov 2026 | Viewed by 357 | Submission Open
Keywords: HMGA1; HMGA2; chromatin architecture; oncogenic signaling; tumor progression; biomarkers; therapeutic targeting
(This special issue belongs to the Section Molecular Cancer Biology)
Epigenetic Alterations in Human Tumors
edited by Michail Panagiotidis and
submission deadline 30 Nov 2026 | Viewed by 352 | Submission Open
Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Minimally Invasive Surgery in Gastrointestinal Cancers
edited by and Fabio Rondelli
submission deadline 30 Nov 2026 | Viewed by 348 | Submission Open
Keywords: laparoscopic surgery; robotic surgery; gastrointestinal cancer; colorectal surgery; hepatobiliary surgery; pancreatic surgery; oesophagogastric surgery; peritoneal surface malignancies
(This special issue belongs to the Section Cancer Therapy)
Biomarkers in Liquid Biopsy: Circulating Tumor DNA (ctDNA), Circulating Tumor Cells (CTCs) and Exosomes
edited by George Zarkavelis
submission deadline 30 Nov 2026 | Viewed by 333 | Submission Open
Keywords: liquid biopsy; circulating tumor DNA; circulating tumor cells; early cancer detection; assessment of minimal residual disease (MRD); monitoring treatment response; identifying resistance to therapy
(This special issue belongs to the Section Methods and Technologies Development)
Novel Approaches to Management of Therapy and Prevention of Pancreatic Cancer
edited by and Vasiliki Liaki
submission deadline 30 Nov 2026 | Viewed by 330 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); targeted therapy; preclinical models; cancer mutiomics; early detection; prevention; precision medicine; biomarkers; drug resistance
(This special issue belongs to the Section Cancer Therapy)
Metabolic Reprogramming and Neuroendocrine Regulation in Cancer: From Pathophysiology to Therapeutic Targets submission deadline 30 Nov 2026 | Viewed by 319 | Submission Open
Keywords: ageing and cancer; breast cancer metabolism; cancer metabolism; inflammation; insulin resistance; metabolic reprogramming; neuroendocrine signaling; obesity and cancer; precision oncology; tumor microenvironment
(This special issue belongs to the Section Cancer Pathophysiology)
Multiple Myeloma: From Molecular Insights to Clinical Treatment
edited by Mikala Gabor
submission deadline 30 Nov 2026 | Viewed by 314 | Submission Open
Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation
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