Tumor Microenvironment Biomarkers: Bridging Immunology and Metastasis
A Special Issue of Cancers (ISSN 2072-6694) belonging to the section "Cancer Biomarkers".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 1282
Editors
Interests: cancer biology; immunotherapy; tumor microenvironment; drug delivery
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The complex and dynamic ecosystem of the tumor microenvironment (TME) is now recognized as a central regulator of cancer progression, therapeutic resistance, and metastasis. Composed of diverse cellular components—including immune cells, cancer-associated fibroblasts, and endothelial cells—and non-cellular elements such as hypoxia and extracellular matrix, the TME creates a supportive niche for tumor survival and spread. A critical challenge in modern oncology is to decode these intricate interactions and translate them into actionable biomarkers and therapeutic targets, effectively bridging our understanding of immunology with the mechanisms of metastatic dissemination.
This Special Issue aims to highlight cutting-edge research that identifies and validates biomarkers within the TME, with a focus on their dual role in modulating immune responses and driving metastatic processes. We invite submissions of original research articles, comprehensive reviews, and translational studies that explore novel cellular and molecular biomarkers, advanced imaging and spatial profiling technologies, and integrative omics approaches. Contributions that elucidate how TME-derived biomarkers can predict therapeutic response, immune evasion, and metastatic potential are particularly encouraged.
By fostering a multidisciplinary dialogue, this collection seeks to advance the development of precision oncology strategies that target the TME, with the ultimate goal of overcoming drug resistance and preventing metastasis to improve long-term patient outcomes.
Dr. Abdel Kareem Azab
Guest Editor
Dr. Tithi Bhattacharyya
Guest Editor Assistant
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- tumor microenvironment
- molecular biomarkers
- cancer progression
- immunomodution
- therapeutic targets
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