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Cancers
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Advances in the Management of Pelvic Tumors: 2nd Edition
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Advances in the Management of Pelvic Tumors: 2nd Edition

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 837

Special Issue Editors

Dr. Giorgia Gaia

E-Mail Website
Guest Editor
Gynecology Unit, ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Milano, Italy
Interests: ovarian cancer; uterine cancer; robotic and laparoscopic surgery; oncology
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Chiara Sighinolfi

E-Mail Website
Guest Editor
Urology Unit, ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Milano, Italy
Interests: urology; oncology; robotic surgery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the second edition of the previous Special Issue entitled “Advances in the Management of Pelvic Tumors”

Pelvic tumors are quite frequent conditions and include prostate, bladder, uterine, ovarian, rectal and anal malignancies. The treatment of tumors occurring within the pelvis can be challenging.

This Special Issue will cover advances in the management of pelvic cancers, including surgical, medical and radiation treatments. It will focus on organ-confined and locally advanced diseases. Novel findings in robotic surgery, as well as medical and personalized therapies, are welcomed.

Dr. Giorgia Gaia
Dr. Maria Chiara Sighinolfi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pelvic cancer
  • prostate cancer
  • bladder cancer
  • uterine cancer
  • ovarian cancer
  • rectal cancer
  • anal cancer

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Published Papers (1 paper)

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Review

15 pages, 473 KB  
Review
Liquid Biopsy in Non-Metastatic Prostate Cancer: Clinical Evidence and Future Directions
by Maria Chiara Sighinolfi, Giuseppe Pallotta, Marzia Del Re, Koosha Moosavi, Or Schubert, Francesco Rossi, Filippo Gavi, Simone Assumma, Enrico Panio, Angelo Totaro, Filippo Turri, Mauro Ragonese, Nazario Foschi, Pierluigi Russo, Ela Patel, Carlo Gandi, Giuseppe Palermo, Eros Scarciglia, Francesco Pinto, Simona Presutti, Marcio Covas Moschovas, Angelo Minucci, Roberto Iacovelli, Chiara Ciccarese, Luca Tagliaferri, Francesco Pierconti, Camilla Nero, Gian Franco Zannoni and Bernardo Roccoadd Show full author list remove Hide full author list
Cancers 2026, 18(5), 800; https://doi.org/10.3390/cancers18050800 - 28 Feb 2026
Viewed by 626
Abstract
Background and Objective: Liquid biopsy has transformed the management of advanced prostate cancer, yet its clinical role in non-metastatic disease remains uncertain. Conventional biomarkers such as PSA, imaging, and pathology have limited ability to capture minimal residual disease and biological aggressiveness. The objective [...] Read more.
Background and Objective: Liquid biopsy has transformed the management of advanced prostate cancer, yet its clinical role in non-metastatic disease remains uncertain. Conventional biomarkers such as PSA, imaging, and pathology have limited ability to capture minimal residual disease and biological aggressiveness. The objective of this review was to critically evaluate the current evidence on circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in non-metastatic prostate cancer, focusing on feasibility, prognostic value, and potential clinical applications. Methods: A narrative review of PubMed-indexed original studies evaluating liquid biopsy in clinically localized or non-metastatic prostate cancer was performed. Eligible studies included patients treated with curative-intent local therapy or experiencing biochemical recurrence without radiologic metastases. Study designs were predominantly prospective or retrospective observational cohorts. Liquid biopsy analytes included CTCs and ctDNA assessed from peripheral blood plasma using EpCAM-based enrichment, targeted next-generation sequencing, whole-genome sequencing, or ultra-sensitive tumor-informed assays. Primary outcomes included detection rates, associations with clinicopathologic features, biochemical recurrence, metastasis-free survival, and overall survival. Key Findings and Limitations: Across 11 studies, CTC detection using EpCAM-based platforms was infrequent in localized disease and biochemical recurrence and showed limited prognostic value (10–11% in preoperative settings). In contrast, ctDNA was detectable in a minority of patients but consistently identified biologically aggressive disease and a higher risk of recurrence when present, particularly using tumor-informed ultra-sensitive assays. Limitations include low detection rates, heterogeneous methodologies, small sample sizes, and predominantly exploratory study designs. Conclusions and Clinical Implications: Currently, its most promising application is not broad screening, but as a selective, biology-driven tool for detecting minimal residual disease and refining risk assessment. CtDNA acts as a biological risk modifier, potentially guiding the escalation or de-escalation of adjuvant therapy. However, prospective biomarker-driven trials are required to validate these strategies before routine clinical implementation. Full article
(This article belongs to the Special Issue Advances in the Management of Pelvic Tumors: 2nd Edition)
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