Pathology of Renal Tumors
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Pathophysiology".
Deadline for manuscript submissions: 30 May 2026 | Viewed by 2
Special Issue Editors
Interests: renal cell carcinoma; FISH; cathepsin K; PEComa; immunohistochemistry
Special Issue Information
Dear Colleagues,
Recent research has greatly expanded our understanding of the pathological features of renal tumors, particularly at the molecular and metabolomic levels. Genomic studies have refined tumor classification, and the latest edition of the World Health Organization now recognizes several new renal tumor entities defined by characteristic genetic alterations, for instance, tumors with SDH or FH deficiency, or those with rearrangements involving TFE3/TFEB or ALK.
At the molecular level, mutations in chromatin-modifying genes (such as SETD2, BAP1, and KDM5C) disrupt histone modifications, leading to genomic instability and impaired DNA repair. These changes contribute to malignant transformation and progression in many renal cancers. In addition, the mTOR pathway has been found to be altered in a subset of renal tumors, promoting cellular metabolism, angiogenesis, and proliferation.
Metabolomic profiling has further revealed consistent alterations in amino-acid, energy, sugar, and nucleotide metabolism, reinforcing the concept that renal tumors may be viewed as a “metabolic disease.” These metabolic shifts may serve as non-invasive biomarkers and help elucidate tumor behaviors such as aggressiveness, immune evasion, and therapy response.
In light of this evolving landscape, this Special Issue of Cancers aims to explore how molecular and metabolomic insights can enhance the classification, diagnosis, and potential treatment of renal cell tumors. We welcome original research articles and comprehensive reviews that critically analyze these topics and further advance our understanding of renal cell tumors.
Prof. Dr. Guido Martignoni
Dr. Anna Caliò
Guest Editors
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Keywords
- renal cell tumors
- diagnosis
- prognosis
- metabolomics
- genomics
- molecular
- immunohistochemistry
- histopathology
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