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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Radiation Therapy for Head and Neck Cancer

edited by

Vassilis Kouloulias

submission deadline 31 Dec 2025 | 5 articles | Viewed by 7783 | Submission Open

Keywords: adaptive radiotherapy ; hyper- and hypo-fractionated radiotherapy ; artificial intelligence in radiotherapy for head and neck cancer ; quality assurance and set-up errors associated with IMRT; VMAT; IGRT; and SGRT techniques ; protons and heavy ions for radiotherapy ; re-irradiation ; nanoparticles plus radiotherapy ; hyperthermia plus radiotherapy ; radiotherapy plus immunotherapy ; the de-escalation of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Precision Oncology for Rare Skin Cancers

edited by Gino K. In and Aparna Nallagangula

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7760 | Submission Open

Keywords: rare skin cancers; melanoma; cutaneous squamous cell carcinoma; basal cell carcinoma; Merkel cell carcinoma; sebaceous carcinoma; adnexal/sweat gland carcinoma; dermatofibrosarcoma protuberans; extramammary Paget’ s disease; cutaneous sarcomas

(This special issue belongs to the Section Molecular Cancer Biology)

Recent Advances in Non-muscle Invasive Bladder Cancer

edited by Paul L. Crispen

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7641 | Submission Open

Keywords: non-muscle invasive bladder cancer; adjuvant therapy; surveillance; BCG refractory; intravesical therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Radiosurgery for Brain Tumors

edited by Anna Petoukhova

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7165 | Submission Open

Keywords: radiosurgery with photons and protons; stereotactic radiosurgery (SRS); brain tumors; gliomas; meningioma; pituitary adenoma; magnetic resonance imaging (MRI); magnetic resonance linac (MRL)

(This special issue belongs to the Section Cancer Therapy)

Multidisciplinary Treatment with Surgery and Chemotherapy of Liver Metastases from Colorectal Cancer

edited by

Luca Viganò

and Pietro Majno

submission deadline 31 Dec 2025 | 1 articles | Viewed by 7090 | Submission Open

Keywords: colorectal liver metastases; liver surgery; oncology; multidisciplinary approach; prognosis; recurrence; precision medicine; genetics; tumor biology; liver transplantation; perioperative therapy and conversion therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Surgical Treatment of Urinary Tumors

edited by Pierre I. Karakiewicz and

Simone Morra

submission deadline 31 Dec 2025 | 2 articles | Viewed by 7011 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; quality of life; urologic oncology

(This special issue belongs to the Section Cancer Therapy)

Innovative Biomarkers and Imaging Techniques for the Early Detection and Risk Stratification of Urological Tumours

edited by

Magdalena Görtz

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6864 | Submission Open

Keywords: urological tumours; novel biomarkers; advanced imaging techniques; early detection; risk stratification; molecular diagnostics; multimodal data integration; personalized treatment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Artificial Intelligence-Assisted Radiomics in Cancer

edited by

Seong K. Mun

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6711 | Submission Open

Keywords: radiomics; learning tools; data normalization; segmentation; artificial intelligence; quantitative imaging; multi-dimensional feature analysis; statistical models; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Surgical Treatment of Hepatocellular Carcinoma

edited by

Wei-Chen Lee

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6621 | Submission Open

Keywords: surgical techniques; surgical indications; surgical outcomes; clinical trials; liver transplantation; adjuvant therapy; basic research

(This special issue belongs to the Section Clinical Research of Cancer)

Enhancing Cancer Treatments through Fluorescence-Guided Surgery

edited by Ibrahim Khot and Yazan Sulaiman Khaled

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6594 | Submission Open

Keywords: fluorescence-guided resection; fluorescent imaging; cancer surgery; tumour targeting; intraoperative staging; oncological fluorescence; precision medicine

(This special issue belongs to the Section Methods and Technologies Development)

Feature Review for Cancer Therapy: 2nd Edition

edited by

Robert Kleszcz

and

Jarosław Paluszczak

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6499 | Submission Open

Keywords: cancer therapy; chemotherapy; targeted therapy; cancer co-treatment; biomarkers; natural compounds; drug-repurposing; nanomaterials

(This special issue belongs to the Section Cancer Therapy)

Feature Paper in Section ‘Cancer Epidemiology and Prevention’ in 2025

edited by Roger Anderson and

Paweł Koczkodaj

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6277 | Submission Open

Keywords: cancer prevention; cancer epidemiology; health policy; public health; global health; health education; health promotion

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Feature Papers in Section “Methods and Technologies Development” in 2025

edited by

Damiano Caruso

and

Marta Zerunian

submission deadline 31 Dec 2025 | 1 articles | Viewed by 6176 | Submission Open

Keywords: innovative diagnostic technology; artificial intelligence; cancer diagnosis; personalized treatment; diagnostic and therapeutic strategies

(This special issue belongs to the Section Methods and Technologies Development)

Latest Advancements in Health-Related Quality of Life Research in Cancer Survivorship (2nd Edition)

edited by

Richard Crevenna

and

Thomas Licht

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5913 | Submission Open

Keywords: cancer survivors; oncology; psycho-oncology; health-related quality of life; patient-reported outcome measures; self-report

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Advances in Breast and Gynecologic Cancer Pathology: Molecular Insights and Therapeutic Implications

edited by

Hisham Bahmad

submission deadline 31 Dec 2025 | 1 articles | Viewed by 5755 | Submission Open

Keywords: breast cancer; gynecologic malignancies; diagnostic pathology; molecular biomarkers; histopathology; cytopathology; prognostic markers; targeted therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Clear Cell Renal Cell Carcinoma 2024–2025

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5671 | Submission Open

Keywords: clear cell renal cell carcinoma; pathology; diagnosis; hypoxia; intratumor heterogeneity; immune checkpoint blockage antiangiogenic therapy

(This special issue belongs to the Section Cancer Pathophysiology)

Feature Papers in Section “Cancer Informatics and Big Data”

edited by

Jason Roszik

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5373 | Submission Open

Keywords: artificial intelligence; deep learning; next-generation sequencing; precision medicine and clinical decision-making; single-cell data analytics

(This special issue belongs to the Section Cancer Informatics and Big Data)

Novel Treatments for Ocular and Periocular Cancers

edited by

Vidhya R. Rao

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5300 | Submission Open

Keywords: ocular cancer; intraocular tumor; retinoblastoma; uveal melanoma

(This special issue belongs to the Section Cancer Therapy)

New Perspectives in the Management of Central Nervous System (CNS) Tumors

edited by

Alessia Pellerino

, Francesco Bruno and

Teresa Somma

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5089 | Submission Open

Keywords: gliomas; brain metastases; leptomeningeal metastases; liquid biopsy; neuroradiological tools; brain surgery; targeted therapy; immunotherapy; clinical trials; molecular factors

(This special issue belongs to the Section Cancer Therapy)

Molecular Mechanisms in Bone and Soft Tissue Sarcomas

edited by

Alexander L. Lazarides

and Zachary D.C. Burke

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4688 | Submission Open

Keywords: sarcoma; bone sarcoma; soft tissue sarcoma; osteosarcoma; molecular level; translation

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights on Management of Acute Lymphoblastic Leukemia in the Contemporary Era

edited by Talha Badar

submission deadline 31 Dec 2025 | 1 articles | Viewed by 4555 | Submission Open

Keywords: B-cell ALL; T-cell ALL; MRD in ALL; Ph+ve ALL; CAR T-cells; NGS-MRD; menin inhibitors; blinatumomab; inotuzumab; ponatinib; BCR-ABL1; TKI

(This special issue belongs to the Section Cancer Therapy)

New Challenges in Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia

edited by Federico Mosna and Irene Cavattoni

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4508 | Submission Open

Keywords: acute myeloid leukemia (AML); allogeneic hematopoietic stem cells transplantation (allo-HSCT); immunotherapy; leukemic stem cells; graft versus host disease (GVHD); infections in immunodepressed patients; immune reconstitution; post-transplant management; long-term results; clinical

(This special issue belongs to the Section Cancer Therapy)

Advances in Ovarian Cancer Treatment: Past, Present and Future

edited by Dimitrios Tsolakidis and Dimitrios Zouzoulas

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4385 | Submission Open

Keywords: ovarian cancer; cytoreductive surgery; HIPEC; chemotherapy; immunotherapy

(This special issue belongs to the Section Cancer Therapy)

Burkitt Lymphoma: From Pathogenesis to Current Treatments

edited by Lorenzo Leoncini and

German K. Ott

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4272 | Submission Open

Keywords: Burkitt lymphoma; high-grade B-cell lymphoma; EBV; NGS; whole-exome sequencing; RNAseq; methylation analysis; tumor microenvironment; immunotherapy; chemotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Diagnostics and Prognostics in the Management of Intrathoracic Malignancies

edited by Akshay Jatin Patel and Marcus Taylor

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3997 | Submission Open

Keywords: intrathoracic malignancies; diagnostics; prognostics; molecular biomarkers; radiomics; artificial intelligence; immunobiological parameters; personalized therapy

(This special issue belongs to the Section Methods and Technologies Development)

Endometrial Cancer—from Diagnosis to Management

edited by Mingxin Shi and

Xiang Zhao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3906 | Submission Open

Keywords: endometrial cancer; prognosis; diagnosis; novel biomarker; immunotherapy; targeted therapy; prevention

(This special issue belongs to the Section Cancer Therapy)

Innovations in Addressing Disparities in Cancer

edited by

Rajesh Singh

and

Shailesh Singh

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3710 | Submission Open

Keywords: artificial intelligence on health equity; artificial intelligence and machine learning technologies in cancer care; genomic testing and biomarkers; AI in social determinants of health; health justice; precision medicine and health informatics; innovative cancer care delivery model for overcoming health disparity; equity lens; racial differences in the immunological landscape; racial differences in treatment and disease outcome

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Oral Cancer: Prevention and Early Detection (2nd Edition)

edited by

Gianluca Tenore

and

Umberto Romeo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3643 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Insights into Microbial-Based Cancer Therapy

edited by Amitabha Ray

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3635 | Submission Open

Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment

(This special issue belongs to the Section Cancer Therapy)

Novel Therapeutic Targets for Metastatic Lung Cancer

edited by

Andrea De Giglio

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3454 | Submission Open

Keywords: metastatic lung cancer; targeted therapy; immunotherapy; resistance mechanisms; tumor microenvironment; biomarkers; novel drug targets; translational oncology; precision medicine; epigenetic modulation

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in the Section “Cancer Therapy” in 2025

edited by

Abdullah Esmail

, Qiang Wang and

Hiroyuki Takei

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3350 | Submission Open

Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.

(This special issue belongs to the Section Cancer Therapy)

Image-Guided Adaptive Radiation Therapy (IGART): Advancing Precision Oncology

edited by An Liu, Bin Cai and Murat Surucu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3349 | Submission Open

Keywords: advanced imaging techniques; adaptive radiotherapy; computational models

(This special issue belongs to the Section Methods and Technologies Development)

Palliative Care and Pain Management in Cancer

edited by María Fernández-Gonzáles and Moira O'Connor

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3154 | Submission Open

Keywords: pain; quality of life; palliative care; non-pharmacological; pharmacological; cancer; metastasis; advanced cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Chemotherapy and Immunotherapy of Lung Cancer

edited by

Sonia Vallet

and Klaus Hackner

submission deadline 31 Dec 2025 | 1 articles | Viewed by 3119 | Submission Open

Keywords: immune checkpoint inhibitors; immunotherapy; lung cancer; programmed-death ligand; chemoimmunotherapy; non-small-cell lung cancer; small-cell lung cancer

(This special issue belongs to the Section Cancer Therapy)

Advances in the Molecular Biology of Sarcoma and Drug Development

edited by Francis Hornicek and

Zhenfeng Duan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2862 | Submission Open

Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy

(This special issue belongs to the Section Molecular Cancer Biology)

New Insights into Kidney Disease Development and Therapy Strategies

edited by

José I. López

and

Claudia Manini

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2747 | Submission Open

(This special issue belongs to the Section Cancer Therapy)

Surgical Innovations in Advanced Gastric Cancer

edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2745 | Submission Open

Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Research and Treatment

edited by

Huaitian Liu

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2636 | Submission Open

Keywords: breast cancer; tumor microenvironment; immune microenvironment; intratumoral heterogeneity; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Advanced Ovarian Cancer (2nd Edition)

edited by

Sheng-Mou Hsiao

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2506 | Submission Open

Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy

(This special issue belongs to the Section Cancer Therapy)

Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape

edited by Jon Mallen-St Clair

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2292 | Submission Open

Keywords: oropharyngeal cancer; human papillomavirus; clinical trials; transoral robotic surgery; epidemiology; HPV-related oropharyngeal cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Lymphoma Biology, Pathology and Stem Cells

edited by

Mingyi Chen

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2185 | Submission Open

Keywords: lymphoma biology; pathology; CAR-T; immunotherapy; stem cell transplant

(This special issue belongs to the Section Cancer Pathophysiology)

New Insights in the Management of Resectable Esophageal Malignancy

edited by

Tania Triantafyllou

and Dimitrios A. Theodorou

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1980 | Submission Open

Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection

(This special issue belongs to the Section Methods and Technologies Development)

Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery

edited by

Margherita Cortini

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1971 | Submission Open

Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening

(This special issue belongs to the Section Cancer Drug Development)

Cutaneous Metastases: State-of-the-Art Research and Management

edited by Marios N. Papadakis and

Dimitra Koumaki

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1876 | Submission Open

Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes

(This special issue belongs to the Section Cancer Metastasis)

Chromatin-Remodeling Factors in Cancer Cells

edited by

Sudhakar Jha

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1803 | Submission Open

Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies

(This special issue belongs to the Section Cancer Pathophysiology)

At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition

edited by

Kenta Masui

and

Linlin Guo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1686 | Submission Open

Keywords: cancer metabolism; epigenetic reprogramming; histone modification; DNA methylation; chromatin structure; intermediary metabolites; microenvironment; mTOR complexes; glioblastoma

(This special issue belongs to the Section Cancer Pathophysiology)

Accelerated Partial Breast Irradiation

edited by Roxolyana Abdah-Bortnyak

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1479 | Submission Open

Keywords: radiotherapy; accelerated partial breast irradiation; breast cancer; intraoperative radiotherapy; external beam radiotherapy; brachytherapy

(This special issue belongs to the Section Cancer Therapy)

New Insights into Pheochromocytoma and Paraganglioma

edited by

Wolfgang Raber

submission deadline 31 Dec 2025 | 2 articles | Viewed by 875 | Submission Open

Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards

(This special issue belongs to the Section Clinical Research of Cancer)

The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes

edited by

Andrea Dell'Amore

and

Alessio Campisi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 670 | Submission Open

Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment

(This special issue belongs to the Section Clinical Research of Cancer)

Facial Paralysis in Cancer Patients—from Diagnosis to Treatment and Facial Reanimation

edited by