Recent Advances in Non-muscle Invasive Bladder Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1272

Special Issue Editor


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Guest Editor
Department of Urology, University of Florida, Gainesville, FL 32611, USA
Interests: urothelial carcinoma; non-muscle invasive; muscle invasive; radical cystectomy; BCG; upper tract urothelial carcinoma

Special Issue Information

Dear Colleagues,

Non-muscle invasive bladder cancer represents a wide disease spectrum. Risk stratification based on tumor size, number, grade, and T stage guides treatment and surveillance protocols. Continued advancements have led to a rapid evolution in the management of non-muscle invasive disease. Endoscopic techniques have expanded past traditional monopolar resection to include en-bloc laser-based resections. More options are now available to enhance disease surveillance following resection, including enhanced cystoscopy and new urine-based markers to evaluate for disease recurrence. Multiple efforts have been completed and are underway to expand options for adjuvant therapy following tumor resection. This includes BCG naive intermediate and high-risk non-muscle invasive disease and BCG refractory disease. Trials evaluating intravesical therapy include viral-based treatment, chemotherapy, and the combination of systemic immunotherapy and targeted therapy. This Special Issue will highlight the current state of the art in the diagnosis, management and surveillance of non-muscle invasive bladder cancer

Prof. Dr. Paul L. Crispen
Guest Editor

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Keywords

  • non-muscle invasive bladder cancer
  • adjuvant therapy
  • surveillance
  • BCG refractory
  • intravesical therapy

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Published Papers (1 paper)

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Review

14 pages, 266 KiB  
Review
The Promise of Radiotherapy in High-Risk Non-Muscle Invasive Bladder Cancer
by Becky Bola, Peter J. Hoskin, Vijay Sangar and Ananya Choudhury
Cancers 2025, 17(4), 628; https://doi.org/10.3390/cancers17040628 - 13 Feb 2025
Viewed by 704
Abstract
Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative treatments. Radiotherapy is not the standard of care for non-muscle invasive bladder cancer (NMIBC), despite being routinely [...] Read more.
Global shortages, toxicities, and high levels of incomplete treatment with Bacillus Calmette Guerin (BCG) for non-muscle invasive bladder cancer has resulted in increasing interest in alternative treatments. Radiotherapy is not the standard of care for non-muscle invasive bladder cancer (NMIBC), despite being routinely used in muscle invasive bladder cancer. Modern techniques and advances in technology mean that radiotherapy can be delivered with increased precision in reducing normal tissue damage. Developing novel biomarker approaches, together with combination approaches with radiosensitisers and other systemic treatments, means that radiotherapy could offer greater benefits than current treatments with BCG or surgery. This review summarises the current landscape and future potential of radiotherapy for high-risk NMIBC. Full article
(This article belongs to the Special Issue Recent Advances in Non-muscle Invasive Bladder Cancer)
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