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Cancers
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Feature Papers in Section “Methods and Technologies Development” in 2025
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Feature Papers in Section “Methods and Technologies Development” in 2025

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 699

Special Issue Editors

Dr. Damiano Caruso

E-Mail Website
Guest Editor
Radiology Unit, Department of Surgical and Medical Sciences and Translational Medicine, Sant’Andrea University Hospital, University of Rome Sapienza, Via di Grottarossa 1035, 00189 Rome, Italy
Interests: imaging; oncology; CT; MRI; artificial intelligence; radiomics; response to therapy
Special Issues, Collections and Topics in MDPI journals
Dr. Marta Zerunian

E-Mail Website
Guest Editor
Department of Surgical and Medical Sciences and Translational Medicine, Radiology Unit, Sant’Andrea University Hospital, University of Rome Sapienza, Via di Grottarossa 1035, 00189 Rome, Italy
Interests: oncologic imaging; quantitative imaging; artificial intelligence application; MRI; radiomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This collection serves as the second edition of the Special Issue “Feature Papers in Section “Methods and Technologies Development”" (https://www.mdpi.com/journal/cancers/special_issues/2L3316G2T9). 

Medicine and medical imaging have a central role to play in the screening, diagnosis, treatment, and follow-up of cancer. New technologies play a pivotal role in improving early detection, precise characterization, and therapeutic strategies for patients affected by cancer. Today, new methods are emerging that benefit from innovative technological changes. A striking example is the advent in medical research of Artificial Intelligence, which has a wide variety of applications, contributing to improving various medical processes (e.g., imaging acquisitions, big data integration, response to therapy prediction, etc.). As these technologies continue to rapidly develop, it is important to share the latest innovations in this dynamic field and to facilitate the dissemination of knowledge in order to improve cancer diagnosis and treatment on a large scale. 

We are delighted to present this Special Issue of Cancers, which is titled "Feature Paper in Section “Methods and Technologies Development”". This Special Issue is dedicated to the intersection of new technological strategies and cancer diagnostic methods, marking a milestone in the evolution of diagnostic and therapeutic strategies. 

We hope that contributions featured in this Special Issue will reflect the collaborative work of multidisciplinary experts in the fields of medicine, data science, and technology.

Dr. Damiano Caruso
Dr. Marta Zerunian
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • innovative diagnostic technology
  • artificial intelligence
  • cancer diagnosis
  • personalized treatment
  • diagnostic and therapeutic strategies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Review

30 pages, 955 KiB  
Review
Breaking Barriers with Sound: The Implementation of Histotripsy in Cancer
by Ashutosh P. Raman, Parker L. Kotlarz, Alexis E. Giff, Katherine A. Goundry, Paul Laeseke, Erica M. Knavel Koepsel, Mosa Alhamami and Dania Daye
Cancers 2025, 17(15), 2548; https://doi.org/10.3390/cancers17152548 - 1 Aug 2025
Viewed by 539
Abstract
Histotripsy is a novel, noninvasive, non-thermal technology invented in 2004 for the precise destruction of biologic tissue. It offers a powerful alternative to more conventional thermal or surgical interventions. Using short-pulse, low-duty cycle ultrasonic waves, histotripsy creates cavitation bubble clouds that selectively and [...] Read more.
Histotripsy is a novel, noninvasive, non-thermal technology invented in 2004 for the precise destruction of biologic tissue. It offers a powerful alternative to more conventional thermal or surgical interventions. Using short-pulse, low-duty cycle ultrasonic waves, histotripsy creates cavitation bubble clouds that selectively and precisely destroy targeted tissue in a predefined volume while sparing critical structures like bile ducts, ureters, and blood vessels. Such precision is of value when treating tumors near vital structures. The FDA has cleared histotripsy for the treatment of all liver tumors. Major medical centers are currently spearheading clinical trials, and some institutions have already integrated the technology into patient care. Histotripsy is now being studied for a host of other cancers, including primary kidney and pancreatic tumors. Preclinical murine and porcine models have already revealed promising outcomes. One of histotripsy’s primary advantages is its non-thermal mechanical actuation. This feature allows it to circumvent the limitations of heat-based techniques, including the heat sink effect and unpredictable treatment margins near sensitive tissues. In addition to its non-invasive ablative capacities, it is being preliminarily explored for its potential to induce immunomodulation and promote abscopal inhibition of distant, untreated tumors through CD8+ T cell responses. Thus, it may provide a multilayered therapeutic effect in the treatment of cancer. Histotripsy has the potential to improve precision and outcomes across a multitude of specialties, from oncology to cardiovascular medicine. Continued trials are crucial to further expand its applications and validate its long-term efficacy. Due to the speed of recent developments, the goal of this review is to provide a comprehensive and updated overview of histotripsy. It will explore its physics-based mechanisms, differentiating it from similar technologies, discuss its clinical applications, and examine its advantages, limitations, and future. Full article
(This article belongs to the Special Issue Feature Papers in Section “Methods and Technologies Development” in 2025)
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