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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in the Fertility-Sparing Treatment of Gynecological Cancers

edited by

Giorgia Mangili

and

Raffaella Cioffi

submission deadline 30 Apr 2026 | Viewed by 121 | Submission Open

Keywords: fertility-sparing treatment; gynecologic oncology; fertility preservation; oncofertility; conservative surgery; recurrence risk; pregnancy outcomes; biomarkers in fertility preservation; assisted reproductive technology; long-term follow-up

(This special issue belongs to the Section Cancer Therapy)

Lifestyle Interventions in Reducing Side Effects of Cancer Treatment and Improving Quality of Life

edited by

Cristina García-Muñoz

Javier Martinez-Calderon

and Juan Carlos Hernández-Rodríguez

submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open

Keywords: lifestyle interventions; side effects of cancer treatment; patient-reported outcomes; multidisciplinary and transdisciplinary care; cancer survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Cancer Stem Cells: From Molecular Mechanisms of Development to Potential of Targeted Therapy

edited by

Masaharu Seno

and

Mary J.C. Hendrix

submission deadline 30 Apr 2026 | Viewed by 120 | Submission Open

Keywords: tumor microenvironment; inflammation; hypoxia; inflammasome; cancer initiation; cellular plasticity; tumor associated cells; tumor heterogeneity; epithelial– mesenchymal-transition; metastasis; vascular-/lymph-angiogenesis; oncogenic signal transduction; transcription factor; epigenetics; transcriptomics; genetic/metabolic reprogramming; biomarkers; drug/radiation resistance; recurrence; molecular targeting; drug delivery; inhibitors; precision medicine; personalized medicine; patient-derived (orthotopic) xenograft

(This special issue belongs to the Section Cancer Therapy)

PARP Inhibitors in Cancers: 2nd Edition

edited by

Jose Manuel Rodriguez-Vargas

submission deadline 30 Apr 2026 | Viewed by 116 | Submission Open

Keywords: PARP inhibitors; clinical relevance; cancer progression; DNA repair mechanisms; cancer cells

(This special issue belongs to the Section Molecular Cancer Biology)

Management of Orbital Tumors

edited by

Peerooz Saeed

submission deadline 30 Apr 2026 | Viewed by 114 | Submission Open

Keywords: orbital tumor; diagnostic; multidisciplinary approaches; personalized treatment; imaging techniques

(This special issue belongs to the Section Clinical Research of Cancer)

Developments, Challenges and Uncertainties in Delivering Stereotactic Ablative Body Radiotherapy to Solid Tumours

edited by Crispin T. Hiley and Iain Phillips

submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open

Keywords: radiotherapy; oligometastatic cancer; oligoprogressive cancer; SABR

(This special issue belongs to the Section Cancer Therapy)

Non-Melanoma Skin Cancer: Promises and Challenges

edited by

Francesca De Felice

and

Valerio Nardone

submission deadline 30 Apr 2026 | Viewed by 102 | Submission Open

Keywords: non-melanoma skin cancer; AI; radiotherapy; immunotherapy; surgery; biomarker; technique

(This special issue belongs to the Section Cancer Therapy)

EGFR-Tyrosine Kinase Inhibitor (EGFR-TKI) for Non-Small Cell Lung Cancer

edited by

Francesca Iommelli

submission deadline 30 Apr 2026 | Viewed by 101 | Submission Open

Keywords: EGFR TKIs; secondary mutations; alternative signaling pathway activation cancer progression; lung cancer

(This special issue belongs to the Section Cancer Therapy)

Lung Cancer: Major Pulmonary Resections and Lymph Node Dissection in the Era of Evolving Therapies

edited by Giuseppe Marulli

submission deadline 30 Apr 2026 | Viewed by 99 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); pneumonectomy; bilobectomy; perioperative management; postoperative drainage; complications of major lung resections; immune checkpoint inhibitors; targeted therapies; surgical oncology; thoracic surgery

(This special issue belongs to the Section Cancer Therapy)

Liquid Biopsies in Gynecologic Cancer

edited by

Antonio Ieni

Vincenzo Fiorentino

and Ludovica Pepe

submission deadline 30 Apr 2026 | Viewed by 94 | Submission Open

Keywords: liquid biopsy; gynecologic cancer; circulating tumor DNA (ctDNA); ovarian cancer; endometrial cancer; cervical cancer; early detection; personalized medicine; cancer monitoring; non-invasive diagnostics

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Research and Clinical Applications of Gynecologic Cancer Detection Technologies

edited by Porfyrios Korompelis

submission deadline 30 Apr 2026 | Viewed by 89 | Submission Open

Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies

(This special issue belongs to the Section Methods and Technologies Development)

Clinical Research on the Relationship Between Diet and Cancer Development (2nd Edition)

edited by

Zsuzsanna Németh

submission deadline 30 Apr 2026 | Viewed by 88 | Submission Open

Keywords: diet; nutrition; complementary therapy; vitamins; minerals; micro-nutrients; survival; cancer

(This special issue belongs to the Section Clinical Research of Cancer)

Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research

edited by

Xuemei Xie

and Tamer Saad Kaoud

submission deadline 30 Apr 2026 | Viewed by 85 | Submission Open

Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research

(This special issue belongs to the Section Clinical Research of Cancer)

Tumor Model for the Development of Anti-Cancer Drugs

edited by

Joohee Jung

submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open

Keywords: tumor models; preclinical cancer models; organoids and spheroids; patient-derived xenografts (PDX); syngeneic models; 3D bioprinting (tumors); tumor-on-chip; drug development; cancer immunotherapy; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Cellular Plasticity: Tumorigenesis and Therapy (2nd Edition)

edited by

Claudia Peitzsch

and

Ina Kurth

submission deadline 30 Apr 2026 | Viewed by 79 | Submission Open

Keywords: cell-of-origin; cellular plasticity; clonal evolution; cellular states; metastatic cascade; therapy resistance

(This special issue belongs to the Section Cancer Therapy)

Potential Therapeutic Targets and Non-Invasive Procedures for Improving the Treatment and Follow-Up of HPV-Associated Malignancies (2nd Edition)

edited by

Xavier Sastre-Garau

submission deadline 30 Apr 2026 | Viewed by 76 | Submission Open

Keywords: therapeutic targets in HPV-associated cancers; HPV-targeted therapy; immunotherapy in HPV-associated carcinomas; circulating HPV DNA

(This special issue belongs to the Section Infectious Agents and Cancer)

Role of Myeloid Cells in the Regulation of Cancer Onset and Development

edited by Rita Campanelli

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: myeloid cells; myeloid-derived suppressor cells; hematological malignancies; solid cancers; inflammation; angiogenesis

(This special issue belongs to the Section Tumor Microenvironment)

Adverse Effects During Cancer Treatment

edited by Yan Gong

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy

(This special issue belongs to the Section Cancer Therapy)

Surgical Treatment and Postoperative Outcomes of Gynecological Cancers

edited by Lauren S. Prescott

submission deadline 30 Apr 2026 | Viewed by 48 | Submission Open

Keywords: gynecologic cancers; quality improvement; surgical outcomes; perioperative optimization; surgery; hysterectomy; ovarian cancer; endometrial cancer; cervical cancer

(This special issue belongs to the Section Cancer Therapy)

New Insights in Esophageal Cancer Diagnosis and Treatment

edited by

Virendra Joshi

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: esophageal cancer; diagnosis; targeted screening; endoscopic treatment

(This special issue belongs to the Section Cancer Therapy)

Cutaneous T-Cell Lymphomas in Special Populations

edited by

Stefan K. Barta

and Caroline Myers

submission deadline 30 Apr 2026 | Viewed by 24 | Submission Open

Keywords: cutaneous T-cell lymphoma; adult T-cell leukemia/lymphoma; lymphoproliferative disorder; hematopoietic stem cell transplant; secondary malignancy; pediatric lymphoma; skin of color; health care disparities; translational research

Advances in Biliary Tract Cancer: Multidisciplinary Perspectives in Surgery, Endoscopic Management, and Epidemiology

edited by Hiroyuki Kato

submission deadline 30 Apr 2026 | Viewed by 17 | Submission Open

Keywords: biliary tract cancer; cholangiocarcinoma; gallbladder cancer; ampullary cancer; hepatobiliary surgery; ERCP; biliary drainage; epidemiology; immunotherapy; multidisciplinary treatment; translational research

Advances in Virus-Associated Head and Neck Cancer

edited by

Joanna Katarzyna Strzelczyk

submission deadline 1 May 2026 | 3 articles | Viewed by 9369 | Submission Open

Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV

(This special issue belongs to the Section Infectious Agents and Cancer)

Treatment Response Biomarkers in Hepatocellular Carcinoma: From Basic Science to Clinical Validation

edited by

Paul T. Thevenot

submission deadline 1 May 2026 | 3 articles | Viewed by 5711 | Submission Open

Keywords: hepatocellular carcinoma; prognostic biomarkers; liver-directed therapy; immune checkpoint inhibitors; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Medical Imaging for Cancer Detection and Diagnosis

edited by Claudia R. Mello-Thoms and Mark Anastasio

submission deadline 1 May 2026 | 1 articles | Viewed by 5207 | Submission Open

Keywords: photon-counting CT applications and developments; radiomics; AI and ML applications; collaborative CAD/AI; computational pathology; multimodality imaging of cancer; especially in vivo; emerging cancer imaging modalities; cancer imaging; machine learning; artificial intelligence; medical imaging

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cell Adhesion in Human Cancer

edited by

Takashi Kojima

, Makoto Osanai and

Akira Ikari

submission deadline 1 May 2026 | 2 articles | Viewed by 4795 | Submission Open

Keywords: cell-to-cell adhesion; tight junctions; cytoskeleton; cancer; signal transduction pathways; transcriptional factors; EMT; cell metabolism; mechanical tension; human cells

(This special issue belongs to the Section Molecular Cancer Biology)

Research Advances and Therapeutic Strategies (RATS) in Cardio-Oncology

edited by

Avirup Guha

Viraj Shah

and

Tarek Nahle

submission deadline 1 May 2026 | 2 articles | Viewed by 3385 | Submission Open

Keywords: cardiotoxicity; artificial intelligence; multi-omics; cardiac toxicities; surveillance; cardioprotective agents; multimodal imaging

(This special issue belongs to the Section Cancer Therapy)

Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)

edited by Kouji Izumi

submission deadline 1 May 2026 | 1 articles | Viewed by 2671 | Submission Open

Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent

(This special issue belongs to the Section Cancer Therapy)

Protein Kinases and Signal Transduction Pathways in Regulating Tumor Growth

edited by

Ralf Landgraf

submission deadline 1 May 2026 | 1 articles | Viewed by 898 | Submission Open

Keywords: protein kinases; protein kinase inhibitors; protein phosphatases; inositol kinases; signal integration; kinase– lipid interaction

(This special issue belongs to the Section Cancer Biomarkers)

Advances of Particle Therapy in Prostate Cancer—2nd Edition

edited by

Xinning Wang

submission deadline 7 May 2026 | Viewed by 301 | Submission Open

Keywords: prostate cancer; particle therapy; radiation therapy; diagnosis; treatment; SBRT; IMRT

(This special issue belongs to the Section Cancer Therapy)

Rehabilitation Opportunities in Cancer Survivorship

edited by

Marie Carmen Valenza

and Alejandro Heredia-Ciuro

submission deadline 8 May 2026 | 3 articles | Viewed by 6321 | Submission Open

Keywords: cancer; rehabilitation; sequelae; disability; impairment

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Artificial Intelligence for Cancer Precision Medicine

edited by Chenyang Shen and

Yujie Chi

submission deadline 8 May 2026 | Viewed by 26 | Submission Open

Keywords: artificial intelligence; cancer; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Epigenetics in Cancer and Drug Therapeutics

edited by Bethsebie Sailo and Anup R. Sharma

submission deadline 10 May 2026 | 1 articles | Viewed by 2286 | Submission Open

Keywords: cancer epigenetics; chromatin remodeling complexes; histone modifiers; DNA methylation; molecular target; cancer therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Hepatocellular Carcinoma Progression and Metastasis

edited by

Ching-Sheng Hsu

submission deadline 10 May 2026 | 1 articles | Viewed by 2046 | Submission Open

Keywords: hepatocellular carcinoma; tumor progression; metastasis; liver cancer; angiogenesis; epithelial– mesenchymal transition; tumor microenvironment; molecular pathways; biomarkers; targeted therapy; systemic therapy

(This special issue belongs to the Section Cancer Metastasis)

Genetics in Hematological Malignancies

edited by

Monika Lejman

submission deadline 10 May 2026 | 1 articles | Viewed by 1498 | Submission Open

Keywords: hematological malignancies; genomic alterations; personalized medicine; next-generation sequencing; epigenetics; biomarkers; leukemia; lymphoma; myeloma; genetic profiling

(This special issue belongs to the Section Molecular Cancer Biology)

Artificial Intelligence for Network-Based Oncomarker Discovery and Cancer Prediction

edited by Oleg Blyuss

submission deadline 10 May 2026 | 2 articles | Viewed by 1441 | Submission Open

Keywords: artificial intelligence (AI); network-based biomarkers; graph neural networks (GNNs); multi-omic integration; cancer prediction; oncomarker discovery; prognostic and predictive biomarkers

(This special issue belongs to the Section Cancer Informatics and Big Data)

Targeted Therapy of Pediatric Cancer (2nd Edition)

edited by

Günther H.S. Richter

submission deadline 10 May 2026 | 1 articles | Viewed by 1072 | Submission Open

Keywords: leukemia; lymphoma; pediatric solid malignancies; targeted therapy; biomarker discovery; actionable mutations; drug vulnerabilities; combination therapy; immunotherapeutic approaches; preclinical studies

(This special issue belongs to the Section Pediatric Oncology)

Oncoproteins in Cancers: Transcriptional Regulation, Signaling and Targeted Therapy

edited by

Ravindran Caspa Gokulan

and

Francis Ali-Osman

submission deadline 11 May 2026 | Viewed by 206 | Submission Open

Keywords: oncoproteins; targeted therapy; oncogenic signaling pathways; tumor microenvironment; oxidative stress and cancer; tumorigenesis; cancer chemoprevention

(This special issue belongs to the Section Molecular Cancer Biology)

Molecular and Clinical Challenges in Metastatic and Oligometastatic Genitourinary Cancers

edited by Marlon Perera

submission deadline 11 May 2026 | Viewed by 25 | Submission Open

Keywords: genitourinary cancers; oligometastatic disease; metastasis-directed therapy; precision oncology; molecular profiling; biomarkers; liquid biopsy; tumour microenvironment; imaging and radiomics

(This special issue belongs to the Section Cancer Metastasis)

Systemic Treatment for Breast Cancer

edited by

Luigia Stefania Stucci

submission deadline 12 May 2026 | Viewed by 26 | Submission Open

Keywords: breast cancer; biomarker; treatment; management

(This special issue belongs to the Section Cancer Therapy)

Immune-Related Adverse Events in Cancer Immunotherapy

edited by Kate Young and Anna Olsson-Brown

submission deadline 15 May 2026 | 5 articles | Viewed by 14325 | Submission Open

Keywords: check point inhibitors (CPIs); immunotherapy; irAEs; immune checkpoint inhibitors (ICIs); survivorship; long-term toxicity; steroid refractory; biologics; CAR-T; TILs

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Infectious Agents and Cancer in Children and Adolescents

edited by

Emmanouel Hatzipantelis

and Eleni Tsotridou

submission deadline 15 May 2026 | 4 articles | Viewed by 10711 | Submission Open

Keywords: infectious agents; immune system; tumor development; immunological memory; oncolytic viruses

(This special issue belongs to the Section Infectious Agents and Cancer)

Endoscopic Advances in Gastrointestinal Oncology

edited by Eduardo Rodrigues-Pinto

submission deadline 15 May 2026 | 1 articles | Viewed by 5353 | Submission Open

Keywords: endoscopic oncology; endoscopic screening; endoscopic resection; endoscopic palliation; staging

(This special issue belongs to the Section Cancer Therapy)

Recent Advance in Colorectal Cancer Liver Metastases

edited by

Peter Metrakos

and Jennifer Kalil

submission deadline 15 May 2026 | 3 articles | Viewed by 4966 | Submission Open

Keywords: colorectal cancer liver metastases; histological growth patterns; chemotherapy optimization; liver regeneration; future liver remnant; liquid biopsy; treatment resistance

(This special issue belongs to the Section Cancer Metastasis)

Surgical Management of Non-Small Cell Lung Cancer

edited by József Furák

submission deadline 15 May 2026 | 4 articles | Viewed by 3513 | Submission Open

Keywords: non-small cell lung cancer; surgery; treatment; segmentectomy

(This special issue belongs to the Section Cancer Therapy)

Breast Cancer Screening: Global Practices and Future Directions

edited by Rudolf Morant

submission deadline 15 May 2026 | 2 articles | Viewed by 1271 | Submission Open

Keywords: mammography screening; organized screening programs; tomosynthesis; 2D mammography; artificial intelligence; personalized screening

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Recent Advances in Trachea, Bronchus and Lung Cancer Management: 2nd Edition

edited by

Serafeim Chrysovalantis Kotoulas

, Dionisios G. Spyratos and

Athanasia Pataka

submission deadline 15 May 2026 | 1 articles | Viewed by 1072 | Submission Open

Keywords: trachea; bronchus and lung cancer; non-small cell lung cancer (NSCLC); small cell lung cancer (SCLC); cancer management; clinical suspicion; diagnosis; treatment; prevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Integrative Histopathological–Molecular–Computational Analysis of Primary Brain Tumors

edited by

Adriana Olar

submission deadline 15 May 2026 | Viewed by 567 | Submission Open

Keywords: brain tumor histopathology; neuropathology; molecular pathology; digital pathology; artificial intelligence; bioinformatics; computational pathology; deep learning

(This special issue belongs to the Section Cancer Informatics and Big Data)

Minimally Invasive Gastric Cancer Surgery

edited by

Gian Luca Baiocchi

, Simone Giacopuzzi and Felix Berlth

submission deadline 15 May 2026 | Viewed by 377 | Submission Open

Keywords: gastric cancer; laparoscopy; robotic surgery; fluorescence; minimally invasive surgery; lymphadenectomy

(This special issue belongs to the Section Cancer Therapy)

Targeted Therapy for Liver Metastases

edited by

Gianluca Rompianesi

and

Jacopo Lanari

submission deadline 15 May 2026 | Viewed by 298 | Submission Open

Keywords: targeted therapy; liver metastases; biological therapy

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 551-600 on page 12 of 24.

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