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Exercise Benefits Brain Function: The Monoamine Connection

by Tzu-Wei Lin 1 and Yu-Min Kuo 1,2,*
Institute of Basic Medical Sciences, National Cheng Kung University, Tainan 70101, Taiwan
Department of Cell Biology and Anatomy, National Cheng Kung University, Tainan 70101, Taiwan
Author to whom correspondence should be addressed.
Brain Sci. 2013, 3(1), 39-53;
Received: 13 September 2012 / Revised: 29 October 2012 / Accepted: 7 January 2013 / Published: 11 January 2013
(This article belongs to the Special Issue Exercise and Brain Function)
The beneficial effects of exercise on brain function have been demonstrated in animal models and in a growing number of clinical studies on humans. There are multiple mechanisms that account for the brain-enhancing effects of exercise, including neuroinflammation, vascularization, antioxidation, energy adaptation, and regulations on neurotrophic factors and neurotransmitters. Dopamine (DA), noradrenaline (NE), and serotonin (5-HT) are the three major monoamine neurotransmitters that are known to be modulated by exercise. This review focuses on how these three neurotransmitters contribute to exercise affecting brain function and how it can work against neurological disorders. View Full-Text
Keywords: exercise; brain function; monoamine exercise; brain function; monoamine
MDPI and ACS Style

Lin, T.-W.; Kuo, Y.-M. Exercise Benefits Brain Function: The Monoamine Connection. Brain Sci. 2013, 3, 39-53.

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