The Role of Modulating Intracellular Signaling in Immune System

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2663

Special Issue Editor

Institute of Physiological Chemistry and Pathobiochemsistry, University of Muenster, Muenster, Germany
Interests: extracellular matrix; immunology

Special Issue Information

Dear Colleagues,

The regulation of intracellular signals plays an indispensable role in the development of immune cells, maintaining the function of immune cells in peripheral tissues, and initiating both innate and adaptive immune responses.

The continuous overactivation of intracellular signaling pathways can lead to autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus (SLE), Crohn's disease, and psoriasis. This Special Issue of Biomolecules covers, but is not limited to, the latest advances in cytokine storms, tissue-resident immune cells, cancer immunotherapy, autophagy, immunotherapy, and drug development.

This Special Issue of Biomolecules focuses on the latest and groundbreaking research in this broad field, and you are welcome to submit relevant manuscripts. It is noteworthy that both research and review articles are welcome.

Dr. Jian Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • signaling pathway
  • inflammation
  • autoimmune disease
  • treatment

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

17 pages, 719 KiB  
Review
Endothelial Cell Dysfunction Due to Molecules Secreted by Macrophages in Sepsis
by Heng He, Wei Zhang, Luofeng Jiang, Xirui Tong, Yongjun Zheng and Zhaofan Xia
Biomolecules 2024, 14(8), 980; https://doi.org/10.3390/biom14080980 - 9 Aug 2024
Cited by 1 | Viewed by 2243
Abstract
Sepsis is recognized as a syndrome of systemic inflammatory reaction induced by dysregulation of the body’s immunity against infection. The multiple organ dysfunction associated with sepsis is a serious threat to the patient’s life. Endothelial cell dysfunction has been extensively studied in sepsis. [...] Read more.
Sepsis is recognized as a syndrome of systemic inflammatory reaction induced by dysregulation of the body’s immunity against infection. The multiple organ dysfunction associated with sepsis is a serious threat to the patient’s life. Endothelial cell dysfunction has been extensively studied in sepsis. However, the role of macrophages in sepsis is not well understood and the intrinsic link between the two cells has not been elucidated. Macrophages are first-line cells of the immune response, whereas endothelial cells are a class of cells that are highly altered in function and morphology. In sepsis, various cytokines secreted by macrophages and endothelial cell dysfunction are inextricably linked. Therefore, investigating how macrophages affect endothelial cells could offer a theoretical foundation for the treatment of sepsis. This review links molecules (TNF-α, CCL2, ROS, VEGF, MMP-9, and NO) secreted by macrophages under inflammatory conditions to endothelial cell dysfunction (adhesion, permeability, and coagulability), refining the pathophysiologic mechanisms of sepsis. At the same time, multiple approaches (a variety of miRNA and medicines) regulating macrophage polarization are also summarized, providing new insights into reversing endothelial cell dysfunction and improving the outcome of sepsis treatment. Full article
(This article belongs to the Special Issue The Role of Modulating Intracellular Signaling in Immune System)
Show Figures

Figure 1

Back to TopTop