Advances in Liver X Receptors

Dear Colleagues,

The nuclear receptor liver X receptors α (LXRα) and LXRβ are transcription factors activated by oxysterols and regulate cholesterol homeostasis. LXRs also play important roles in the regulation of innate and adaptive immune responses in leukocytes. Thus, LXRs could be therapeutic targets for various diseases such as cardiovascular diseases, non-alcoholic steatohepatitis, cancer, infectious diseases and autoimmune diseases. However, their cell-type specific target genes and functions have not completely been explored.

This Special Issue welcomes original articles and reviews focused on the recent advances in the regulation of metabolism and immunity by LXRs in physiological and disease conditions. We also welcome articles regarding other novel LXR functions and the development of novel LXR ligands for protection and therapy in relation to disease treatment.

We look forward to reading your contributions.

Dr. Kaori Endo-Umeda
Prof. Dr. Makoto Makishima
Guest Editors

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