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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Novel Materials for Biomedical Applications: 3rd Edition

edited by

Jayakumar Rajadas

and

Mustafeez Mujtaba Babar

submission deadline 15 Dec 2025 | Viewed by 93 | Submission Open

Keywords: micro-/nanocarriers; synthesis or conjugation of biomaterials; drug delivery; targeted therapy/immunotherapy for combinatorial treatment; regenerative medicine/tissue engineering

(This special issue belongs to the Section Bio-Engineered Materials)

Metabolism and Milk Quality in Dairy Cows: Dietary Influences and Transcriptomic Insights

edited by

Massimo Bionaz

submission deadline 20 Dec 2025 | Viewed by 195 | Submission Open

Keywords: dairy cows; transcriptomics; milk quality; nutrigenomics; epigenomics; diet; ration; transition period; lactation; dry period

Inflammatory Pathways in Heart Failure

edited by

Pietro Scicchitano

submission deadline 30 Dec 2025 | Viewed by 131 | Submission Open

Keywords: inflammation; heart failure; molecular mechanism; heart failure therapies

(This special issue belongs to the Section Molecular Medicine)

Feature Papers in the Natural and Bio-Derived Molecules Section

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2025 | 9 articles | Viewed by 52715 | Submission Open

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Molecular Advances in Mechanism and Regulation of Lifespan and Aging

edited by Mark McCormick

submission deadline 31 Dec 2025 | 7 articles | Viewed by 37408 | Submission Open

Keywords: aging; lifespan; healthspan

(This special issue belongs to the Section Molecular Biology)

Biochemistry in Medicine—Honorary Special Issue Commemorating Research and Work of Professors Jan O. Aaseth and Jan Alexander

edited by Sonia Distante and

Per M. Roos

submission deadline 31 Dec 2025 | 5 articles | Viewed by 35249 | Submission Open

Keywords: medical biochemistry; endocrinology; neurotoxic metals

(This special issue belongs to the Section Molecular Medicine)

Insights from the Editorial Board Members

edited by

Peter E. Nielsen

submission deadline 31 Dec 2025 | 11 articles | Viewed by 25798 | Submission Open

Keywords: structure and function; bioactive and biogenic substances; molecular mechanisms; biomaterials

Tissue Calcification in Normal and Pathological Environments

edited by

Fulvia Ortolani

submission deadline 31 Dec 2025 | 9 articles | Viewed by 25292 | Submission Open

Keywords: calcification; ectopic mineralization; bone; heterotopic ossification; calcium phosphate; calcium carbonate; calcium oxalate; procalcific cell death

(This special issue belongs to the Section Molecular Medicine)

Cellular and Molecular Mechanism of Spermatogenesis

edited by YanHe Lue

submission deadline 31 Dec 2025 | 4 articles | Viewed by 21179 | Submission Open

Keywords: spermatogenesis; regulation; biomolecules

(This special issue belongs to the Section Molecular Reproduction)

Cardiometabolic Disease: Molecular Basis and Therapeutic Approaches

edited by

Nikolaos Theodorakis

and Maria Nikolaou

submission deadline 31 Dec 2025 | 4 articles | Viewed by 20402 | Submission Open

Keywords: cardiometabolic medicine; preventive cardiology; cardiovascular endocrinology and metabolism; obesity; diabetes mellitus; cardiovascular disease

(This special issue belongs to the Section Molecular Medicine)

Neuroimmune Interactions in Neuropsychiatric Diseases

edited by

Luciana Frick

submission deadline 31 Dec 2025 | 4 articles | Viewed by 19315 | Submission Open

Keywords: neurology; psychiatry; immunity; glia

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in DNA and RNA Damage and Repair

edited by

Marino J. E. Resendiz

Chryssostomos Chatgilialoglu

and

Yuan Liu

submission deadline 31 Dec 2025 | 8 articles | Viewed by 18196 | Submission Open

Keywords: reactive oxygen species; DNA damage; DNA repair; RNA damage; RNA repair; molecular mechanisms; biomarkers; antioxidant and redox strategies; oxidative stress

(This special issue belongs to the Section Molecular Biomarkers)

Cell Biology and Biomedical Application of Galectins

edited by

Alexander Timoshenko

submission deadline 31 Dec 2025 | 6 articles | Viewed by 15900 | Submission Open

Keywords: galectins; cell differentiation; stem cells; apoptosis; autophagy; cell adhesion; glycobiology; post-translational modifications; transmembrane signaling; protein trafficking; cancer; heart diseases; fibrosis; inflammation; targeted therapeutics; galectin inhibitors

(This special issue belongs to the Section Chemical Biology)

Natural Bioactives as Leading Molecules for Drug Development

edited by

Chang Liu

Hang Ma

and

Ang Cai

submission deadline 31 Dec 2025 | 7 articles | Viewed by 15362 | Submission Open

Keywords: drug discovery; natural products; leading molecules; isolation and identification; phytochemical investigation; omics approaches

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Melatonin in Normal Physiology and Disease, 2nd Edition

edited by

Georges Maestroni

submission deadline 31 Dec 2025 | 4 articles | Viewed by 15296 | Submission Open

Keywords: circadian rhythms; immunity; skin; reproduction; aging; viral and bacterial infection; inflammation; mesenchymal stem cells; cancer; neurodegenerative diseases; osteoporosis

(This special issue belongs to the Section Molecular Biology)

New Insight into the Molecular Genetics of Neurodevelopmental Disorders

edited by

Luciana Musante

and Flavio Faletra

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14235 | Submission Open

Keywords: neurodevelopmental disorders; next generation sequencing; pathomechanisms; phenotypic spectra; phenotype-genotype correlation

(This special issue belongs to the Section Molecular Genetics)

Genetic and Structural Analyses of Coronaviruses: Insights into SARS-CoV-2 and Beyond

edited by

Stefano Pascarella

submission deadline 31 Dec 2025 | 8 articles | Viewed by 14165 | Submission Open

Keywords: SARS-CoV-2 variants; protein variants; protein structure; virus evolution; mutations; structural bioinformatics; molecular phylogenesis; host– pathogen molecular interactions; molecular immunology; drug discovery

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Molecular and Toxicological Profiling of Drugs of Abuse—in Honor of Professor Félix Carvalho

edited by

João Pedro Silva

and

Vera Marisa Costa

submission deadline 31 Dec 2025 | 3 articles | Viewed by 13725 | Submission Open

Keywords: toxicodynamic; toxicokinetic; amphetamine-type stimulants; cannabis and cannabinoids; cocaine; hallucinogens; new psychoactive substances; opioids; immune modulation

(This special issue belongs to the Section Molecular Medicine)

Molecular Insights into Sex and Evolution

edited by

Ikuo Miura

and

Michihiko Ito

submission deadline 31 Dec 2025 | 5 articles | Viewed by 12739 | Submission Open

Keywords: sex determination; sex chromosome evolution; reproduction; hybridization; speciation; evolution; animals; vertebrates

(This special issue belongs to the Section Molecular Genetics)

Mitochondrial Proteins: From Import and Biogenesis to Complex Functional Network

edited by

Venkatesh Sundararajan

submission deadline 31 Dec 2025 | 4 articles | Viewed by 12255 | Submission Open

Keywords: mitochondrial proteins; import; biogenesis; metabolism; functional network; oxidative stress; small molecules; mitochondrial protein quality control; mitophagy

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Integrating Genetics, Immune Dysregulation, and the Gut Microbiome: Advances in Elucidating IBD Pathophysiology and Emerging Therapeutic Strategies

edited by

Peter W. Jurutka

and

Todd R. Sandrin

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11656 | Submission Open

Keywords: microbiome; biomarkers; Crohn’ s disease; ulcerative colitis; indeterminate colitis; multiomics; gastrointestinal (GI disease); immunology; gut– brain axis; neuropsychology

(This special issue belongs to the Section Molecular Genetics)

Innate Immunomodulation and Inflammation: From Molecular Mechanisms to Pre-Clinical Insights

edited by

Fabián Flores-Borja

Shunbin Ning

and

Michael Torzewski

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11396 | Submission Open

Keywords: innate immunity; therapy; immune checkpoints; cancer; autoimmunity; inflammation; infection; danger-associated molecular patterns; pattern recognition receptors

(This special issue belongs to the Section Molecular Medicine)

Human Reproductive Biology: Uncertainties and Controversies

edited by

Giuseppe Benagiano

Marwan Habiba

and Paola Bianchi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11286 | Submission Open

Keywords: molecular reproduction; endometriosis; endometrium; implantation; decidualization; placenta; cellular senescence; prostaglandin; inflammation; pregnancy; reproduction; implantation; decidualization; endometriosis; assisted reproductive technology; molecular reproductive biology; reproductive biology; reproductive immunology; reproductive medicine; reproductive endocrinology; molecular regulation of reproductive processes; embryo development; reproductive biology; gametogenesis and fertilization

(This special issue belongs to the Section Molecular Reproduction)

Biosynthesis and Function of Thyroid Hormones

edited by

Josef Koehrle

and Eva K. Wirth

submission deadline 31 Dec 2025 | 4 articles | Viewed by 11103 | Submission Open

Keywords: thyroid gland; thyroid follicle; TH release; iodide; deiodinase; TH transmembrane transport; TH receptors; intracellular TH binding proteins; thyroglobulin; sodium– iodide symporter; thyroperoxidase; dual oxidase; thyroid-relevant trace elements

(This special issue belongs to the Section Biological Factors)

Molecular Mechanisms of Cardiovascular Remodeling

edited by

Mingyi Wang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11070 | Submission Open

Keywords: vascular remodeling aging; extracellular matrix; atherosclerosis peripheral; artery disease; chronic heart failure; cardiovascular associated cognitive decline

(This special issue belongs to the Section Molecular Biology)

Molecular Diagnosis and Regulation of Mitochondrial Dysfunction

edited by

Cecilia Giulivi

submission deadline 31 Dec 2025 | 3 articles | Viewed by 10941 | Submission Open

Keywords: metabolic conditions; neurological conditions; genetic diseases; mitochondrial dysfunction; mitochondrial disorders; diagnostics; therapies

(This special issue belongs to the Section Biological Factors)

Antitumor Agents from Natural Sources 2024–2025

edited by

Hang Fai (Henry) Kwok

submission deadline 31 Dec 2025 | 2 articles | Viewed by 10283 | Submission Open

Keywords: antitumor agents; natural sources; cancer prevention and therapy

(This special issue belongs to the Section Natural and Bio-derived Molecules)

The Role of Non-Coding RNAs in Health and Disease

edited by

Narasimman Gurusamy

submission deadline 31 Dec 2025 | 6 articles | Viewed by 9881 | Submission Open

Keywords: non-coding RNA; microRNA (miRNA); long noncoding RNA (lncRNA); circular RNA (circRNA); gene expression regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics)

The Role of Nanoparticles in Tumor Treatment

edited by

Carla Vitorino

submission deadline 31 Dec 2025 | 3 articles | Viewed by 8468 | Submission Open

Keywords: nanoparticles; cancer therapy; nanotechnology

(This special issue belongs to the Section Chemical Biology)

Signal Transduction to Transcription Factors in Health and Disease—Honorary Special Issue Commemorating the Work of Prof. Athanasios G. Papavassiliou

edited by

Christina Piperi

and

George D. Kalliolias

submission deadline 31 Dec 2025 | 4 articles | Viewed by 8246 | Submission Open

(This special issue belongs to the Section Molecular Medicine)

Matrix Metalloproteinases: Mechanisms, Functions and Therapeutic Potential

edited by

Alireza Shoari

, Joshua W. Ogony and

Gokara Mahesh

submission deadline 31 Dec 2025 | 2 articles | Viewed by 8140 | Submission Open

Keywords: matrix metalloproteinases; endopeptidases; MMP inhibitor; tissue homeostasis; disease progression

(This special issue belongs to the Section Enzymology)

Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges

edited by

Atsushi Saito

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7482 | Submission Open

Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials

(This special issue belongs to the Section Bio-Engineered Materials)

Cellular Signaling in Cancer

edited by

Avisek Majumder

, Shabana Bano and Kasturi Nayak

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7003 | Submission Open

Keywords: signaling pathways; cancer; anti-cancer

(This special issue belongs to the Section Cellular Biochemistry)

New Insights into Molecular Mechanisms and Therapeutics for Malaria

edited by

Maria Isabel Veiga

submission deadline 31 Dec 2025 | 2 articles | Viewed by 6892 | Submission Open

Keywords: antimalarial resistance; drug discovery; malaria epidemiology; diagnostic tools; malaria pathophysiology

(This special issue belongs to the Section Molecular Medicine)

Computational Intelligence in Structure and Function Prediction and Modeling of Proteins—2nd Edition

edited by

Jian Zhang

Bi Zhao

and Haiting Chai

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6731 | Submission Open

Keywords: protein tertiary structure; protein folding; protein functions; intrinsic disorder; drug discovery; protein– drug interaction; computational intelligent algorithms; artificial intelligence for proteomics; high-throughput proteomics

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Cellular and Molecular Biology of Neurodevelopment

edited by

David M. Feliciano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6571 | Submission Open

Keywords: neural stem cells; neuroblasts; neurons; glia; microglia; molecular pathways; genes; mutations; pharmacology; toxicology; neurodevelopment; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Biology)

Molecular Biomarkers in Cardiology 2025

edited by

Pietro Scicchitano

submission deadline 31 Dec 2025 | 4 articles | Viewed by 6212 | Submission Open

Keywords: cardiovascular diseases; cardiovascular pathology and histology; carotid plaques and histology; endothelium and endothelial dysfunction; veins diseases; arrhythmias; heart

(This special issue belongs to the Section Molecular Biomarkers)

Barrier Formation and Homeostasis in the Vertebrate Brain

edited by

Ramani Ramchandran

Karthikeyan Thirugnanam

and

Ankan Gupta

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6178 | Submission Open

Keywords: brain endothelial cell; pericytes; choroid plexus; retina; lymphatic; blood; astrocytes; oligodendrocytes; brain ventricle; microglia

(This special issue belongs to the Section Cellular Biochemistry)

Recent Advances in the Enzymatic Synthesis of Bioactive Compounds

edited by

Bartłomiej Zieniuk

submission deadline 31 Dec 2025 | 5 articles | Viewed by 6105 | Submission Open

Keywords: biocatalysis; biotransformation; enzyme-catalyzed reactions; whole-cell catalysis; green chemistry; enzymes; phenolic compounds; polyphenols; lipases; lipophilization; enzymatic synthesis; esterification; transesterification; green and sustainable chemistry approaches; lipid modification

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Chemical Biology and Biotechnology of Nucleosides, Nucleotides, and Nucleic Acids

edited by

Xingguo Liang

and

Xinjing Tang

submission deadline 31 Dec 2025 | 3 articles | Viewed by 6012 | Submission Open

Keywords: nucleosides; nucleotides; nanostructure; circular ssDNA; circular RNA; quadruplex; conjugate; lncRNA; DNAzyme; ribozyme

(This special issue belongs to the Section Chemical Biology)

Antimicrobial Peptides in Nature: Inspiration for Rationally Designed Antimicrobials

edited by

Mire Zloh

and

Rachael Dickman

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5853 | Submission Open

Keywords: antimicrobial resistance; antimicrobial peptides; rational design of peptides; antimicrobial peptide synthesis; peptidomimetic antimicrobial agents

(This special issue belongs to the Section Natural and Bio-derived Molecules)

Gametogenesis and Gamete Interaction, 2nd Edition

edited by

Hitoshi Sawada

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5359 | Submission Open

Keywords: gametogenesis and meiosis; sperm attraction and activation; gamete interaction and recognition; species specificity and self/nonself-recognition in hermaphrodites; acrosome reaction sperm penetration of egg coat; gamete membrane fusion; polyspermy block; egg activation

(This special issue belongs to the Section Molecular Reproduction)

Signaling Pathways as Therapeutic Targets for Cancer

edited by Fabian Benencia

submission deadline 31 Dec 2025 | 3 articles | Viewed by 5334 | Submission Open

Keywords: cancer signaling pathways; cancer metabolism; small molecules; anticancer antibodies; tumor models; combinatorial therapies

(This special issue belongs to the Section Molecular Biology)

Necrotic Cell Death Mechanisms and Therapies

edited by

Ilana Nathan

and

Boris Khalfin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5301 | Submission Open

Keywords: necrosis; mitochondria; lysosomes; reactive oxygen species (ROS); calcium signalling; caspase-independent proteases: serine proteases like CELA; ELA; as well as cathepsin C and B etc.; heat shock proteins (HSPs); epigenetics; necrosis in diseases and therapeutic intervention; necroptosis; ferroptosis; paraptosis; pyroptosis

(This special issue belongs to the Section Cellular Biochemistry)

Calcium Signaling in Cell Function and Dysfunction

edited by

Giorgia Pallafacchina

and Sofia Zanin

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5216 | Submission Open

Keywords: calcium signaling; calcium regulation; cell function; human pathology

(This special issue belongs to the Section Molecular Biology)

Neuron–Astrocyte Interactions in Neurological Function and Disease

edited by Micaela Zonta and Alessandro Di Spiezio

submission deadline 31 Dec 2025 | 2 articles | Viewed by 5126 | Submission Open

Keywords: astrocytes; neuron-astrocyte communication; brain function; neurological disease

(This special issue belongs to the Section Molecular Medicine)

Non-Invasive Biomarkers in Saliva or Urine: Technical and Biological Variability

edited by

Peter Celec

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4859 | Submission Open

Keywords: saliva; urine; non-invasive diagnostics; screening; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Neuroinflammation in Ocular Diseases: Emerging Insights into Mechanisms, Biomarkers, and Therapeutic Targets

edited by

S. Priya Narayanan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4503 | Submission Open

Keywords: neuroinflammation; vision; retina; optic nerve; neurodegeneration; inflammation; biomarker; therapeutic strategies; pharmacological treatments

(This special issue belongs to the Section Molecular Biomarkers)

Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities

edited by

Natalia Osna

and

Kusum K. Kharbanda

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4260 | Submission Open

Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD

(This special issue belongs to the Section Molecular Medicine)

Tumour Suppressor Genes: The Guardians of Cell Integrity

edited by

Nicola Manfrini

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4169 | Submission Open

Keywords: cell cycle; cell growth; cell integrity; cell proliferation; DNA damage; genome integrity; protein homeostasis; migration; invasion; metastasis; apoptosis; autophagy

(This special issue belongs to the Section Molecular Biology)

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