Innate Immunomodulation and Inflammation: From Molecular Mechanisms to Pre-Clinical Insights

Dear Colleagues,

We are pleased to invite you to submit and contribute with your original research and review articles to the upcoming Special Issue, “Innate Immunomodulation and Inflammation,” in the peer-reviewed, open access journal Biomolecules.

The innate immune system constitutes the first line of defense that offers immediate protection against bacterial and viral infection. Further, cells of the innate immune system recognize “danger” signals generated following cell stress, injury and trauma, aging, and cancer. Once activated, innate immunity plays a fundamental role in priming the adaptive immune system for specific and targeted responses that contribute to tissue repair, good health, and survival.

In recent years, there has been an increased understanding of mediators of inflammatory responses and the role of immune checkpoints in the modulation of immune responses. This has led to the development of effective biological agents and therapies that enhance the function of T cells. However, it has now become evident that modulating the function of innate immune cells can also have therapeutic effects. Exciting new studies are providing evidence to support the notion that targeting co-inhibitory or co-stimulatory receptors on innate immune cells, or even modulation of the microbiome, has remarkable potential for therapies not only in cancer but also in autoimmune disease, inflammation, and chronic infection.

The aims of this Special Issue are as follows:

• To define new biomarkers for diseases associated with innate immune cells.
• To highlight novel studies on the characterization of the pharmacological mechanisms of new drugs targeting innate immune cells.
• To showcase the potential of new approaches to modulate innate immune responses for the development of therapies for cancer, autoimmunity, inflammation, and chronic infectious diseases.

For this Special Issue, basic research, in vitro and in vivo investigations, and pre-clinical studies examining the effects of innate cell modulation are welcome.

We look forward to receiving your contributions.

Dr. Fabián Flores-Borja
Dr. Shunbin Ning
Prof. Dr. Michael Torzewski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.