New Insights into Molecular Mechanisms and Therapeutics for Malaria

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1507

Special Issue Editor


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Guest Editor
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Interests: malaria; plasmodium falciparum; antimalarial drugs; resistance; epidemiology; diagnostics; molecular markers; hemozoin; drug transporters
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Special Issue Information

Dear Colleagues,

Malaria remains a serious global health challenge, affecting millions of lives each year. To address this urgent issue, we present a Special Issue dedicated to "New Insights into Mechanisms and Therapeutics for Malaria."

Despite significant progress, the battle against malaria is far from over. The emergence of drug resistance, the complex biology of the malaria parasite and the limited portfolio of drugs available to treat malaria urge for alternative perspectives and innovative solutions.

This Special Issue focuses on providing a platform for the two types of research approach, clinical and laboratory research, offering a deep dive into the mechanisms driving malaria drug resistance, the mode of action of drugs and novel therapeutic approaches.

We aim to bring a collection of articles by experts from around the world, inspiring researchers and policymakers to explore new avenues in diagnostics, treatment, and prevention. By sharing these insights, we aspire to help accelerate the development of more effective therapies and ultimately contribute to efforts to achieve global malaria eradication.

Dr. Maria Isabel Veiga
Guest Editor

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Keywords

  • antimalarial resistance
  • drug discovery
  • malaria epidemiology
  • diagnostic tools
  • malaria pathophysiology

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Published Papers (1 paper)

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Research

22 pages, 7344 KiB  
Article
Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito Anopheles stephensi and Its Capacity to Mobilize Pantothenate and Biotin
by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart and Michael A. Riehle
Biomolecules 2025, 15(1), 59; https://doi.org/10.3390/biom15010059 - 3 Jan 2025
Cited by 1 | Viewed by 958
Abstract
Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. We previously demonstrated that Pan is not only essential for mosquito survival, but also for the development of malaria parasites within the mosquito, [...] Read more.
Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. We previously demonstrated that Pan is not only essential for mosquito survival, but also for the development of malaria parasites within the mosquito, suggesting that targeting Pan and CoA biosynthesis may be a novel approach for malaria control. However, little is known about how Pan is acquired and mobilized within the mosquito. In this work, we examined Pan levels in the important human malaria vector Anopheles stephensi, including the abundance of Pan during immature development and adulthood. We also assessed the distribution of Pan in various adult tissues and examined the impact of provisioning Pan to the mosquito via a sugar or blood meal on mosquito survival and reproduction. Furthermore, we examined how Pan was mobilized in the mosquito via a putative Pan transporter, the A. stephensi sodium multi-vitamin transporter. We demonstrated that this transporter is capable of mobilizing both Pan and biotin (vitamin B7) in a dose dependent manner. We also assessed the distribution of A. stephensi sodium multi-vitamin transporter in the mosquito and its capacity to transport vitamins. This work establishes the basic physiology of Pan uptake and mobilization in the mosquito, providing essential information for Pan based malaria control strategies. Full article
(This article belongs to the Special Issue New Insights into Molecular Mechanisms and Therapeutics for Malaria)
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