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Biomolecules
Special Issues
New Insights into Molecular Mechanisms and Therapeutics for Malaria
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New Insights into Molecular Mechanisms and Therapeutics for Malaria

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 2819

Special Issue Editor

Dr. Maria Isabel Veiga

E-Mail Website
Guest Editor
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
Interests: malaria; plasmodium falciparum; antimalarial drugs; resistance; epidemiology; diagnostics; molecular markers; hemozoin; drug transporters
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Malaria remains a serious global health challenge, affecting millions of lives each year. To address this urgent issue, we present a Special Issue dedicated to "New Insights into Mechanisms and Therapeutics for Malaria."

Despite significant progress, the battle against malaria is far from over. The emergence of drug resistance, the complex biology of the malaria parasite and the limited portfolio of drugs available to treat malaria urge for alternative perspectives and innovative solutions.

This Special Issue focuses on providing a platform for the two types of research approach, clinical and laboratory research, offering a deep dive into the mechanisms driving malaria drug resistance, the mode of action of drugs and novel therapeutic approaches.

We aim to bring a collection of articles by experts from around the world, inspiring researchers and policymakers to explore new avenues in diagnostics, treatment, and prevention. By sharing these insights, we aspire to help accelerate the development of more effective therapies and ultimately contribute to efforts to achieve global malaria eradication.

Dr. Maria Isabel Veiga
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antimalarial resistance
  • drug discovery
  • malaria epidemiology
  • diagnostic tools
  • malaria pathophysiology

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

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22 pages, 7344 KiB  
Article
Characterization of the Sodium Multi-Vitamin Transporter in the Mosquito Anopheles stephensi and Its Capacity to Mobilize Pantothenate and Biotin
by Jun Isoe, Brendan F. Riske, Megan E. Dobson, Hannah L. Kaylor, Jessica C. Brady, Yared Debebe, Laura M. Saavedra, Shirley Luckhart and Michael A. Riehle
Biomolecules 2025, 15(1), 59; https://doi.org/10.3390/biom15010059 - 3 Jan 2025
Cited by 2 | Viewed by 1244
Abstract
Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. We previously demonstrated that Pan is not only essential for mosquito survival, but also for the development of malaria parasites within the mosquito, [...] Read more.
Pantothenate (Pan), or vitamin B5, is essential for the synthesis of co-enzyme A (CoA), acetyl-CoA, and numerous downstream physiological processes. We previously demonstrated that Pan is not only essential for mosquito survival, but also for the development of malaria parasites within the mosquito, suggesting that targeting Pan and CoA biosynthesis may be a novel approach for malaria control. However, little is known about how Pan is acquired and mobilized within the mosquito. In this work, we examined Pan levels in the important human malaria vector Anopheles stephensi, including the abundance of Pan during immature development and adulthood. We also assessed the distribution of Pan in various adult tissues and examined the impact of provisioning Pan to the mosquito via a sugar or blood meal on mosquito survival and reproduction. Furthermore, we examined how Pan was mobilized in the mosquito via a putative Pan transporter, the A. stephensi sodium multi-vitamin transporter. We demonstrated that this transporter is capable of mobilizing both Pan and biotin (vitamin B7) in a dose dependent manner. We also assessed the distribution of A. stephensi sodium multi-vitamin transporter in the mosquito and its capacity to transport vitamins. This work establishes the basic physiology of Pan uptake and mobilization in the mosquito, providing essential information for Pan based malaria control strategies. Full article
(This article belongs to the Special Issue New Insights into Molecular Mechanisms and Therapeutics for Malaria)
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Review

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30 pages, 1348 KiB  
Review
Emerging Molecular Mechanisms in Malaria Pathogenesis and Novel Therapeutic Approaches: A Focus on P. falciparum Malaria
by Adekunle Sanyaolu, Aleksandra Marinkovic, Stephanie Prakash, Vyshnavy Balendra, Omar Shazley, Tatiana Gardellini, Abdul Jan, Kokab Younis, Chuku Okorie and Ricardo Izurieta
Biomolecules 2025, 15(7), 1038; https://doi.org/10.3390/biom15071038 - 17 Jul 2025
Viewed by 951
Abstract
Malaria is still one of the biggest global health problems, especially in parts of the world, such as sub-Saharan Africa, which remains most heavily affected. Despite significant advancements in testing, treatment, and prevention, malaria continues to seriously impact millions, primarily young children and [...] Read more.
Malaria is still one of the biggest global health problems, especially in parts of the world, such as sub-Saharan Africa, which remains most heavily affected. Despite significant advancements in testing, treatment, and prevention, malaria continues to seriously impact millions, primarily young children and populations in rural and impoverished areas. This paper looks at how the malaria parasite works inside the body, how it avoids the immune system, and how it becomes resistant to current drugs. Thanks to new advances in genetic and biochemical research, scientists are discovering new weak points in the parasite that could lead to better treatments. New vaccines, like RTS, S and R21, along with antibody-based therapies, offer renewed hope; however, extending the duration of the immunity they induce and ensuring effectiveness across diverse parasite strains remain significant challenges. Solving the malaria crisis will require more than science—it also necessitates equitable and timely access to treatments, robust health systems, and international collaboration. Continued research and global cooperation bring the world closer to ending malaria for good. Full article
(This article belongs to the Special Issue New Insights into Molecular Mechanisms and Therapeutics for Malaria)
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