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Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Mechanotransduction in Cellular Biology

edited by

Frederick H. Silver

submission deadline 31 Jul 2026 | 4 articles | Viewed by 12862 | Submission Open

Keywords: cell membrane; cytosol; nuclear membrane; integrin; mechanotransduction; map kinase pathway; ERKs; JNKs; p38/SAPKs; YAP/TAZ; Hippo pathway

(This special issue belongs to the Section Cellular Biochemistry)

Cysteine and Selenocysteine in Antioxidant Defense, Protein Synthesis and Signaling Pathways

edited by

Maria Wrobel

and

Halina Jurkowska

submission deadline 31 Jul 2026 | 3 articles | Viewed by 7750 | Submission Open

Keywords: cysteine; selenocysteine; taurine; hydrogen sulfide; hydrogen selenide; selenoproteins; sulfurtransferases; H2S precursors; antioxidants; diseases related to sulfur metabolism

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Platelet Disease, Thrombosis and Hemostasis

edited by

José Rivera

submission deadline 31 Jul 2026 | 2 articles | Viewed by 5817 | Submission Open

Keywords: platelets; hemostasis and thrombosis; inherited platelet disorders; coagulation; immunothrombosis; miRNA; GPVI; Runx1; antiplatelet therapy

(This special issue belongs to the Section Molecular Biology)

Novel Mechanisms of Bacterial Antibiotic Resistance

edited by

Dorothea K. Thompson

submission deadline 31 Jul 2026 | 2 articles | Viewed by 3926 | Submission Open

Keywords: molecular mechanisms of antibiotic resistance; bacterial resistome acquired and intrinsic; drug resistance antibiotic modification/degradation; antibiotic efflux; antibiotic target modification antibiotic permeability; antibiotic sequestration proteins; beta-lactamases; bioinformatic and phylogenetic approaches

(This special issue belongs to the Section Biological Factors)

Functional Peptides and Their Interactions (3rd Edition)

edited by

Mikhail Soloviev

and

Simon M. Cutting

submission deadline 31 Jul 2026 | 3 articles | Viewed by 3683 | Submission Open

Keywords: peptides; antimicrobial peptides; immunomodulatory peptides; neuropeptides; signaling peptides; regulatory peptides; cyclic peptides; peptidomics; peptide profiling; peptoids; peptide engineering; peptide docking; peptide therapeutics; peptide self-assembly; biomaterials; biocatalysts; small proteins

(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Exerkines as Mediators of Exercise Benefits: Mechanisms, Functions and Applications

edited by

Sara Missaglia

and Eleonora Martegani

submission deadline 31 Jul 2026 | 2 articles | Viewed by 2807 | Submission Open

Keywords: exerkines; myokines; adipokines; cytokines; exercise-induced benefits

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Mast Cells Activation and Medical Implications

edited by

Grzegorz Porebski

and

Matija Rijavec

submission deadline 31 Jul 2026 | 1 articles | Viewed by 2513 | Submission Open

Keywords: mast cells; allergy; immediate hypersensitivity; molecular mechanisms

(This special issue belongs to the Section Biological Factors)

Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition

edited by

Grzegorz Janusz

and

Anna Pawlik

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1798 | Submission Open

Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering

(This special issue belongs to the Section Enzymology)

Function and Regulation of Hyaluronan and Hyalectins in Disease

edited by

Edward N. Harris

and

Michele T. Pritchard

submission deadline 31 Jul 2026 | 1 articles | Viewed by 1195 | Submission Open

Keywords: hyaluonan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling

(This special issue belongs to the Section Chemical Biology)

Heterocyclic Compounds: Synthesis, Characterization, and Validation

edited by

Monika Pitucha

submission deadline 31 Jul 2026 | 1 articles | Viewed by 478 | Submission Open

Keywords: heterocyclic compounds; synthesis; spectroscopy; molecular modeling; biological activity; radiopharmaceuticals

(This special issue belongs to the Section Chemical Biology)

Molecular Mechanisms of Skeletal Muscle Growth and Loss in Health, Aging, and Disease

edited by

Khaled Kamal

submission deadline 31 Jul 2026 | Viewed by 322 | Submission Open

Keywords: skeletal muscle; muscle growth and atrophy; metabolic signaling (anabolic/catabolic); mechanotransduction; redox biology and oxidative stress; inflammation and immune signaling; obesity and metabolic disease; sarcopenia and aging; cachexia and neuromuscular disease; extracellular vesicles and exosomes

(This special issue belongs to the Section Molecular Biology)

Epigenetic Programming of Cellular States

edited by

Benjamin Carone

submission deadline 31 Jul 2026 | Viewed by 214 | Submission Open

Keywords: iPSCs; stem cells; reprogramming; chromatin; epigenetics

Redox Dysregulation and Mitochondrial Adaptation in Kidney Disease

edited by

Liang-Jun Yan

submission deadline 31 Jul 2026 | Viewed by 208 | Submission Open

Keywords: acute kidney injury; chronic kidney disease; diabetic nephropathy; diabetic kidney disease; redox imbalance; reductive stress; reactive oxygen species; oxidative stress; mitochondrial stress response and adaptation; mitochondrial abnormalities; mitochondrial homeostasis; mitophagy; unfolded protein response

LDL Receptor Family in Metabolic Homeostasis, Neurodevelopmental Disorders, and Signaling Pathways

edited by

María-Paz Marzolo

submission deadline 31 Jul 2026 | Viewed by 180 | Submission Open

Keywords: LDL receptor family; lipid metabolism; cholesterol homeostasis; neurodevelopmental and neuropsychiatric disorders; neurodegeneration; receptor-mediated endocytosis; Wnt and reelin signaling pathways; apolipoproteins; Alzheimer's disease; Parkinson's disease

Nanotechnology in Agriculture and the Environment: From Molecular Mechanisms to Sustainable Applications

edited by

Nubia Zuverza-Mena

and Luis Hernandez-Adame

submission deadline 31 Jul 2026 | Viewed by 180 | Submission Open

Keywords: nanotechnology; molecular mechanisms; biomolecules; environment; sustainable agriculture

(This special issue belongs to the Section Bio-Engineered Materials)

Therapeutics Targeting Pathogenic Mechanisms of Leishmaniasis

edited by

Kwang Poo Chang

submission deadline 31 Jul 2026 | Viewed by 178 | Submission Open

Keywords: leishmaniasis; host– parasite interactions; pathogenicity; precision medicine; AI-assisted development of therapeutics

Design and Applications of 3D Bioprinting

edited by

Saman Naghieh

and

Chaozong Liu

submission deadline 31 Jul 2026 | Viewed by 134 | Submission Open

Keywords: 3D bioprinting; biofabrication; tissue engineering; regenerative medicine; smart biomaterials; scaffold design; organ models; personalized therapeutics; biomedical additive manufacturing; translational bioprinting

(This special issue belongs to the Section Bio-Engineered Materials)

Hepatic Stellate Cells and Immune Microenvironment in Hepatocellular Carcinoma

edited by

Tai-long Pan

submission deadline 31 Jul 2026 | Viewed by 114 | Submission Open

Keywords: hepatic stellate cell; hepatocellular carcinoma; immune microenvironment; extracellular matrix; epigenetics; tumor microenvironment; inflammation

(This special issue belongs to the Section Molecular Medicine)

CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics

edited by

Eric B. Kmiec

and

Kelly Banas

submission deadline 31 Jul 2026 | Viewed by 88 | Submission Open

Keywords: CRISPR; gene editing; genome engineering; cancer therapy; solid tumors; precision medicine; translational research; functional genomics; tumor-specific targeting; CRISPR diagnostics; off-target effects

(This special issue belongs to the Section Molecular Medicine)

Mutagenesis and Genetic Instability in Genome Evolution and in Cancer: Mechanisms, Consequences, and Therapeutic Perspectives

edited by

Said Aoufouchi

and Rabii Ameziane El Hassani

submission deadline 31 Jul 2026 | Viewed by 67 | Submission Open

Keywords: genomic instability; mutagenesis; evolution; genetic diversification DNA repair; epigenetic; cancers; therapy resistance

(This special issue belongs to the Section Molecular Biology)

DNA Replication Stress Tolerance Mechanisms: From Nucleoside Analog Repair to Therapeutic Strategies

edited by

Kouji Hirota

and Ryotaro Kawasumi

submission deadline 31 Jul 2026 | Viewed by 61 | Submission Open

Keywords: nucleoside analogs; DNA replication; DNA damage tolerance; DNA repair; DNA damage checkpoint; targeted cancer therapy

(This special issue belongs to the Section Molecular Genetics)

Significance of KEAP1 and NRF2 Protein-Protein Interactions in Cancer

edited by

Mihaela Matovina

submission deadline 31 Jul 2026 | Viewed by 53 | Submission Open

Keywords: cancer; protein– protein interactions (PPIs); KEAP1; NRF2

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Exploration of Drug Targets for Liver Fibrosis Based on Hepatic Stellate Cells and Extracellular Matrix Remodeling

edited by

Nadezda Apostolova

submission deadline 31 Jul 2026 | Viewed by 42 | Submission Open

Keywords: liver fibrosis; collagen; hepatic stellate cells; senescence; animal models; extracellular matrix; hepatitis; cytokines; biomarkers; MASH; MASLD; cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Medicine)

Cellular and Molecular Mechanisms of Autoimmune Diseases

edited by Ming-Lin Liu

submission deadline 31 Jul 2026 | Viewed by 40 | Submission Open

Keywords: autoimmune diseases; genetic and epigenetic; immune tolerance; T and B cell pathways; cytokines; molecular therapeutics

(This special issue belongs to the Section Molecular Biology)

Tracking Aging and Stress: Omics-Based Insights into Physiology and Pathology

edited by

Dominika Drulis-Fajdasz

submission deadline 31 Jul 2026 | Viewed by 31 | Submission Open

Keywords: genetic proteomic; lipidomic metabolomic; aging senescence; neurodegeneration; cellular stress

(This special issue belongs to the Section Biological Factors)

Metabolic and Signaling Networks in Therapy Resistance

edited by

Jun He

and Lei Zhao

submission deadline 31 Jul 2026 | Viewed by 25 | Submission Open

Keywords: therapeutic resistance; metabolic reprogramming; systems biology; signaling networks

(This special issue belongs to the Section Molecular Medicine)

Microbial Biocontrol and Plant-Microbe Interactions, 2nd Edition

edited by

Shahzad Munir

submission deadline 31 Jul 2026 | Viewed by 19 | Submission Open

Keywords: endophytic microbiome for disease management; plant– microbe interactions; microbial colonization for disease control; plant– insect– pathogen interactions; microbial and plant metabolites against pathogens; pathogen signaling; microbial communities shift for disease prevention; omics approaches; abiotic stress response

(This special issue belongs to the Section Cellular Biochemistry)

Protein Spreading in Neurodegenerative Diseases: From Mechanisms to Therapeutics

edited by

Xiaobo Mao

and

Enrico Moro

submission deadline 31 Jul 2026 | Viewed by 7 | Submission Open

Keywords: neurodegeneration; protein aggregation; Alzheimer disease; Lewy bodies; frontotemporal dementia

(This special issue belongs to the Section Molecular Medicine)

Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors

edited by

Hewang Lee

and

Pedro A. José

submission deadline 14 Aug 2026 | Viewed by 265 | Submission Open

Keywords: neuropeptides; dopamine; blood pressure; G protein-coupled receptors; oxidative stress kidney; vasculature; brain

The Role of Immune Cells in Human Arterial Diseases

edited by

Klaus Ley

submission deadline 14 Aug 2026 | Viewed by 38 | Submission Open

Keywords: carotid artery; endarterectomy; atherosclerosis; macrophage; lymphocytes; T cells; autoimmunity; smooth muscle cells; endothelial cells

(This special issue belongs to the Section Biological Factors)

TRP Channels in Cardiovascular and Inflammatory Disease, 2nd Edition

edited by

Susan D. Brain

submission deadline 20 Aug 2026 | 1 articles | Viewed by 2051 | Submission Open

Keywords: TRP channels; TRP ligands; biological functions; new drugs; cardiovascular diseases; inflammation

(This special issue belongs to the Section Molecular Medicine)

Novel Evidence About Hydrogen Sulfide (H₂S)-Donor Molecules as Innovative Therapeutical Tools 2025

edited by

Alma Martelli

submission deadline 20 Aug 2026 | Viewed by 265 | Submission Open

Keywords: hydrogen sulfide (H2S)-donor; H2S-releasing molecule; H2S-hybrid drug; hydrogen sulfide; therapeutical tool

(This special issue belongs to the Section Chemical Biology)

Advancing Next-Generation Agricultural Research with Multi-Omics Approaches

edited by

Rui Li

and Xinmin Li

submission deadline 20 Aug 2026 | Viewed by 105 | Submission Open

Keywords: multiomics and bioinformatics; functional genomics; molecular breeding; molecular plant biology; functional genomics; sustainable agricultural biotechnology; nutrition and health of functional foods

(This special issue belongs to the Section Molecular Genetics)

Glycosylation: Cutting-Edge Approach to Targeted Therapy in Cancer

edited by

Myron R. Szewczuk

submission deadline 30 Aug 2026 | Viewed by 27 | Submission Open

Keywords: glycosylation; glycobiology; N-glycans; O-glycans; glycosyltransferases; glycosidases

(This special issue belongs to the Section Molecular Medicine)

The Molecular and Cellular Mechanisms in Multiple Sclerosis

edited by

Magdalena Zoledziewska

and Maria laura Idda

submission deadline 30 Aug 2026 | Viewed by 12 | Submission Open

Keywords: multiple sclerosis; gene expression; immunophenotyping; molecular-; expression- and protein-quantitative loci QTLs; non-coding RNAs; precision medicine

(This special issue belongs to the Section Molecular Medicine)

Applications of Biomaterials in Medicine and Healthcare

edited by

Patrícia Alves

and

Paula Ferreira

submission deadline 31 Aug 2026 | 4 articles | Viewed by 8424 | Submission Open

Keywords: biomaterials; tissue engineering; biomedical applications; drug delivery systems; medical implants

New Insights into Cardiometabolic Diseases, 2nd Edition

edited by

Gundu Rao

and

Undurti N. Das

submission deadline 31 Aug 2026 | 1 articles | Viewed by 5453 | Submission Open

Keywords: metabolic diseases; hypertension; obesity; type-2 diabetes; vascular diseases; acute vascular events

(This special issue belongs to the Section Molecular Medicine)

Iron Metabolism in Cells

edited by

Magdalena Gryzik

and

Michela Asperti

submission deadline 31 Aug 2026 | Viewed by 1026 | Submission Open

Keywords: iron metabolism; iron-related proteins; iron uptake; iron storage; mitochondrial iron metabolism; iron sensing mechanism; ferroptosis

(This special issue belongs to the Section Cellular Biochemistry)

The Role of Extracellular Non-Coding RNAs in Health and Disease

edited by

Arijit Mukhopadhyay

submission deadline 31 Aug 2026 | Viewed by 132 | Submission Open

Keywords: extracellular vesicles; exosomes; non-coding RNA; microRNA; biomarker

(This special issue belongs to the Section Molecular Biomarkers)

Nanomaterials and Iron Proteins: Molecular Interactions, Structural Characterization and Biomedical Applications

edited by

Georgia C. Papaefthymiou

submission deadline 31 Aug 2026 | Viewed by 81 | Submission Open

Keywords: iron storage (ferritin); iron transport (transferrin; ferroportin); O2 storage (myoglobin); O2 transport (hemoglobin); electron transfer (Fe-S proteins; cytochromes); ferritin degradation; (ferritinophagy); oxidative stress protection (ferritin; Dps proteins); biocompatible iron-oxide nanoparticles; magnetoferritin; biogenic magnetite by magnetotactic bacteria (magnetosomes); iron-based metal– organic frameworks (Fe-MOFs)

(This special issue belongs to the Section Molecular Biology)

From Molecular Mechanisms to Therapeutics: Multidisciplinary Advances in Gene Expression Research

edited by Cristina Maracci

submission deadline 31 Aug 2026 | Viewed by 62 | Submission Open

Keywords: gene regulation; drug design; computational biology; AI modeling; protein synthesis; gene regulatory network; transcription; post-transcriptional regulation; molecular biology

(This special issue belongs to the Section Molecular Genetics)

State-of-the-Art of Myology: 3rd Edition

edited by

Guglielmo Sorci

and

Francesca Riuzzi

submission deadline 31 Aug 2026 | Viewed by 60 | Submission Open

Keywords: embryonic myogenesis; adult myogenesis; exercise-induced muscle injury; muscular dystrophies and muscle diseases; sarcopenia; cachexia; rhabdomyosarcoma; muscle biophysics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms of Antimicrobial Activity and Resistance in Pathogens

edited by

Lia Mara Diţu

submission deadline 31 Aug 2026 | Viewed by 58 | Submission Open

Keywords: MDR profile in fungi; anti-fungal strategies; drug– target interactions; nanotechnology in antimicrobials; quorum-sensing molecular interactions; biofilm

(This special issue belongs to the Section Molecular Biology)

Physiological Responses and Biomolecular Adaptations to Environmental and Biotic Stress in Aquatic Species

edited by

Eleni Golomazou

submission deadline 31 Aug 2026 | Viewed by 42 | Submission Open

Keywords: aquaculture; fish pathogens; fish welfare; health protection

(This special issue belongs to the Section Molecular Biology)

Dynamic Interactions Between Biomolecules: Insights from Bioinformatics and Computational Biology

edited by Jayadev Joshi

submission deadline 31 Aug 2026 | Viewed by 22 | Submission Open

Keywords: biomolecular interactions; molecular dynamics; structural bioinformatics; computational biology; protein interactions; conformational dynamics; machine learning; systems biology; integrative modeling; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Imaging Biomarkers in Inflammation and Metabolic Disorders

edited by

Uwe Himmelreich

submission deadline 31 Aug 2026 | Viewed by 21 | Submission Open

Keywords: inflammation; metabolic disorders; molecular imaging; metabolism; biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Molecular Biomarkers of Oxidative and Nitrosative Stress: Mechanisms, Detection, and Clinical Significance

edited by

Narcyz Knap

and

Michał Woźniak

submission deadline 31 Aug 2026 | Viewed by 13 | Submission Open

Keywords: oxidative stress; nitrosative stress; reactive oxygen species (ROS); reactive nitrogen species (RNS); lipid peroxidation; ferroptosis; protein oxidation; DNA oxidative modifications; antioxidant defense mechanisms; free radicals; redox signaling; redox biomarkers

(This special issue belongs to the Section Molecular Biomarkers)

Glycans in Health and Disease Molecular Insights and Clinical Implications

edited by

Vaibhav Tiwari

submission deadline 31 Aug 2026 | Viewed by 11 | Submission Open

Keywords: glycans; glycobiology; proteoglycans; heparan sulfate; infection; pathogen host cell interaction; disease; cancer; drug discovery

(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)

Molecular Mechanisms and Microenvironmental Regulation in Bone-Related Diseases and Muscle Atrophy

edited by Haitao Wang

submission deadline 1 Sep 2026 | 1 articles | Viewed by 459 | Submission Open

Keywords: bone diseases; muscle atrophy; osteoporosis; osteoarthritis; osteosarcoma; sarcopenia; heterotopic ossification; molecular mechanisms; microenvironment; therapeutic targets

(This special issue belongs to the Section Molecular Medicine)

The Heme Oxygenase/Biliverdin Reductase System in Human Health and Disease: New Molecular Insights and Therapeutic Targets

edited by Cesare Mancuso

submission deadline 1 Sep 2026 | Viewed by 76 | Submission Open

Keywords: Alzheimer’ s disease; bilirubin; cancer; carbon monoxide; cardiovascular diseases; cerebral malaria; diabetes mellitus; drug research and development; inflammation; Parkinson’ s disease

(This special issue belongs to the Section Molecular Medicine)

Displaying special issue 401-450 on page 9 of 10.

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