Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Bioactives from Underexplored Botanical Sources and By-Products for Food Applications
edited by Suelen Pereira Ruiz Herrig, Zilda Cristiani Gazim and Beatriz Cervejeira Bolanho Barros
submission deadline 1 Mar 2027 | Viewed by 332 | Submission Open
Keywords: botanical bioactives; by-products; natural food additives; green extraction
(This special issue belongs to the Section Natural and Bio-derived Molecules)
The Impact of Obesity, Ethnicity, and Genetic Susceptibility on Beta Cell Function
edited by Joseph Proietto
submission deadline 12 Mar 2027 | Viewed by 62 | Submission Open
Keywords: obesity-induced diabetes; beta cell function; diabetes complications; susceptibility; genetics
(This special issue belongs to the Section Biological Factors)
Molecular Mechanisms and Emerging Therapies for Diabetic Cardiomyopathy submission deadline 15 Mar 2027 | Viewed by 96 | Submission Open
Keywords: diabetic cardiomyopathy; diabetes-related cardiac dysfunction; cardiac remodeling; molecular mechanisms; emerging therapies; cardiometabolic disease
(This special issue belongs to the Section Molecular Medicine)
Dynamic Remodeling of the 3D Genome in Development and Diseases
edited by
submission deadline 18 Mar 2027 | Viewed by 75 | Submission Open
Keywords: 3D genome organization; cell fate specification; disease pathogenesis; topologically associating domains (TADs); enhancer–promoter interactions; gene expression regulation
(This special issue belongs to the Section Molecular Reproduction)
Biomarkers in Musculoskeletal and Orthopedic Disorders
edited by
submission deadline 20 Mar 2027 | 2 articles | Viewed by 1721 | Submission Open
Keywords: musculo-skeletal pathologies; orthopaedic infections; synovial fluid analysis
(This special issue belongs to the Section Molecular Biomarkers)
Effects of Microvascular Dysfunction on Neurological and Cardiovascular Diseases
edited by Adjanie Patabendige and
submission deadline 20 Mar 2027 | Viewed by 21 | Submission Open
Keywords: microvascular dysfunction; heart-brain axis; neurovascular interface; blood–brain barrier; stroke; dementia; small vessel disease; hypertension; atrial fibrillation; heart failure
(This special issue belongs to the Section Molecular Medicine)
Signal Transduction and Pathway Regulation in Cancer submission deadline 25 Mar 2027 | 5 articles | Viewed by 4305 | Submission Open
Keywords: signal transduction; pathway modulation; targeted treatment strategies; cancer treatment; drug resistance; cancer diagnosis; cancer prognosis
(This special issue belongs to the Section Molecular Biology)
Computational Analysis and Conformational Modeling for Protein Structure and Interaction: Second Edition
edited by and
submission deadline 26 Mar 2027 | 2 articles | Viewed by 1529 | Submission Open
Keywords: protein structure prediction; drug discovery targeting proteins; structural bioinformatics; molecular dynamics simulations; protein–protein interactions; protein–ligand binding; conformational dynamics; molecular docking studies
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies submission deadline 26 Mar 2027 | Viewed by 509 | Submission Open
Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis
(This special issue belongs to the Section Biological Factors)
Roles of Epigenetics in Plant Defense submission deadline 28 Mar 2027 | Viewed by 60 | Submission Open
Keywords: plant defense; epigenetics; epitranscriptomics; non-coding RNAs; chromatin remodeling; RNA modifications; plant–pathogen interactions; defense priming; CRISPR epigenome editing; genome wide; multi-omics; disease-resistant crops; artificial intelligence (AI); systemic acquired resistance (SAR); induced systemic resistance (ISR); pattern-triggered immunity (PTI); effector-triggered immunity (ETI)
(This special issue belongs to the Section Molecular Genetics)
Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives submission deadline 30 Mar 2027 | 3 articles | Viewed by 3869 | Submission Open
Keywords: skeletal muscle; ageing; muscle physiology; muscle-multiorgan crosstalk; muscle health; muscle atrophy; molecular factors; sedentariness; exercise
(This special issue belongs to the Section Biological Factors)
Endocrine, Immune and Molecular Biomarkers in Pain and Psychosomatic Disorders: Bridging Mechanisms and Medical Application submission deadline 31 Mar 2027 | 3 articles | Viewed by 4964 | Submission Open
Keywords: personalized pain medicine; systems biology of pain; neuroendocrine regulation; molecular biomarkers; psychosomatic disorders
(This special issue belongs to the Section Biological Factors)
Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications
edited by and Anthea Miller
submission deadline 31 Mar 2027 | 2 articles | Viewed by 4033 | Submission Open
Keywords: inflammation; innate immunity; therapeutic targets; immune signaling pathways; pattern-recognition receptors (PRRs)
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Laccases and Laccase-Based Bioproducts: 2nd Edition submission deadline 31 Mar 2027 | 2 articles | Viewed by 3722 | Submission Open
Keywords: laccase; application; heterologous expression; bioproducts; laccase engineering
(This special issue belongs to the Section Enzymology)
Nitric Oxide and Reactive Species in Plant Physiology and Pathology
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3719 | Submission Open
Keywords: nitric oxide; reactive oxygen species; reactive sulfur species; redox signaling; S-nitrosylation; plant stress tolerance; antioxidant systems; phytohormones; metabolic regulation
(This special issue belongs to the Section Biological Factors)
Novel Mechanisms in Renal Blood Pressure Regulation: From Neuropeptides to Angiotensin II and Dopamine Receptors
edited by and
submission deadline 31 Mar 2027 | 2 articles | Viewed by 3258 | Submission Open
Keywords: neuropeptides; dopamine; blood pressure; G protein-coupled receptors; oxidative stress kidney; vasculature; brain
New Insights into Integrins: 2nd Edition
edited by
submission deadline 31 Mar 2027 | 2 articles | Viewed by 1952 | Submission Open
Keywords: integrins; growth factors; ligands; allosteric binding; inflammation-induced activation
(This special issue belongs to the Section Biological Factors)
Cellular Stress, Inflammation, and Metabolic Dysfunction in the Progression of MASLD
edited by Weber Andre Alberto
submission deadline 31 Mar 2027 | 2 articles | Viewed by 1627 | Submission Open
Keywords: MASLD; fibrosis; liver; hepatosteatosis; endoplasmic reticulum stress
(This special issue belongs to the Section Molecular Medicine)
Recent Advances in Structure-Based Inhibitor/Drug Design
edited by and Si‑Ming Liao
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1586 | Submission Open
Keywords: biomolecular interactions; structures and functions of biomolecules; nuclear magnetic resonance (NMR); X-ray crystallography; bioinformatics; structural studies using Artificial Intelligence (AI); machine learning (ML); deep learning (DL); molecular dynamics simulation (MDS)
Natural Compounds with Biomedical Potential submission deadline 31 Mar 2027 | 1 articles | Viewed by 1580 | Submission Open
Keywords: natural compounds; naturat extracts; drug discovery; antimicrobial activity; antioxidant activity; anticancer activity; anti-inflammatory activity; anti-diabetes activity
(This special issue belongs to the Section Chemical Biology)
Molecular Genetics of Parasitic Protozoa submission deadline 31 Mar 2027 | 1 articles | Viewed by 1385 | Submission Open
Keywords: molecular genetics; parasitic protozoa; zoonosis; One Health
(This special issue belongs to the Section Molecular Genetics)
Bone Injuries: New Pharmaceutical, Biomaterial and Therapies
edited by Xinlin Yang
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1293 | Submission Open
Keywords: bone regeneration; biomaterials; drug delivery; tissue engineering; stem cell therapy; osteogenesis; bone repair; regenerative medicine
Multifunctional Nanocarriers for Advanced Therapy and Diagnosis
edited by
submission deadline 31 Mar 2027 | 1 articles | Viewed by 1040 | Submission Open
Keywords: nanocarriers; targeted drug delivery; stimuli-responsive nanoparticles; biological barriers; smart delivery systems; nanotheranostics; functionalized nanoparticles
(This special issue belongs to the Section Bio-Engineered Materials)
Unraveling the Mysteries of Muscle: Advances in Myogenesis, Physiology, and Wasting Disorders
edited by
submission deadline 31 Mar 2027 | Viewed by 854 | Submission Open
Keywords: muscle biology; molecular mechanism; myogenesis; muscle physiology; muscle wasting; sarcopenia; cachexia; muscle-related pathologies
Proteins Governing Genome Architecture and Gene Expression
edited by and
submission deadline 31 Mar 2027 | 1 articles | Viewed by 843 | Submission Open
Keywords: regulatory proteins; genome architecture; gene regulation; chromatin dynamics; structural mechanisms; functional studies; protein–protein interaction; protein–DNA interaction
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Molecular Biology and Therapy of Breast Cancer
edited by
submission deadline 31 Mar 2027 | Viewed by 494 | Submission Open
Keywords: breast cancer; molecular pathology; biomarkers; novel therapy targets; personalized therapy; immunotherapy; tumor microenvironment; tumor stem cells; therapy resistance; non-coding RNA
Non-Invasive Biomarker Screening in Cancer
edited by and F. G. Pinto
submission deadline 31 Mar 2027 | Viewed by 398 | Submission Open
Keywords: non-invasive biomarkers; cancer screening; metabolomics; lipidomics; proteomics; liquid biopsy; early detection; multiomics; precision oncology; diagnostic technologies
(This special issue belongs to the Section Molecular Biomarkers)
Genetic Variations and Gene Expression in Diseases
edited by
submission deadline 31 Mar 2027 | Viewed by 347 | Submission Open
Keywords: omics; gene expression; genetic variation; SNPs; polymorphisms; complex traits; monogenic disorders; gene-environment interactions; transcriptomics; functional analysis
(This special issue belongs to the Section Molecular Biology)
Emerging Bioactive Compounds from Medicinal Plants
edited by Shiau Pin Tan and
submission deadline 31 Mar 2027 | Viewed by 308 | Submission Open
Keywords: bioactive compounds; medicinal plants; molecular mechanisms; green chemistry; bioassay-guided isolation
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Next-Gen Antimicrobials: Discovery, Engineering and Synergistic Approaches
edited by
submission deadline 31 Mar 2027 | Viewed by 241 | Submission Open
Keywords: antimicrobial agents; antimicrobial discovery; antimicrobial engineering; antimicrobial applications; synergistic antimicrobial strategies
(This special issue belongs to the Section Molecular Medicine)
Advances in Plasma Bioscience and Medicine: 3rd Edition submission deadline 31 Mar 2027 | Viewed by 145 | Submission Open
Keywords: plasma medicine; non-thermal plasma; plasma bioscience; biomolecules; reactive oxygen and nitrogen species; cancer therapy; wound healing and tissue regeneration; computational modeling and simulations; plasma–biomolecule interactions; biomedical applications
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Hormonal Mediated Stress Resistance of Horticultural Crops
edited by and
submission deadline 31 Mar 2027 | Viewed by 144 | Submission Open
Keywords: horticultural crops; phytohormones; abiotic and biotic stress; hormonal crosstalk; signal transduction; transcription factor regulation; crop improvement; postharvest physiology
(This special issue belongs to the Section Molecular Biology)
Molecular Insights in Immunogenetics: Structure and Evolution of the Antigen Receptors of the Adaptive Immune Response submission deadline 31 Mar 2027 | Viewed by 101 | Submission Open
Keywords: immunogenetics; immune response; genetic variation; structural interaction; autoimmunity; genomics; transcriptomics; molecular mechanisms
(This special issue belongs to the Section Molecular Genetics)
Mesenchymal Stem Cell Therapy
edited by Feng Dong
submission deadline 31 Mar 2027 | Viewed by 74 | Submission Open
Keywords: cell-free therapy; exosomes; mesenchymal stem cell
(This special issue belongs to the Section Biological Factors)
Effects of Circadian Rhythms and Melatonin on Reproductive Endocrinology and Cell-Aging
edited by
submission deadline 31 Mar 2027 | Viewed by 16 | Submission Open
Keywords: circadian rhythm; melatonin; clock genes; reproduction; aging
(This special issue belongs to the Section Molecular Reproduction)
Innovative Biomolecular Structure Analysis Techniques: 2nd Edition
edited by
submission deadline 31 Mar 2027 | Viewed by 12 | Submission Open
Keywords: macromolecular crystallography; room temperature crystallography; protein ensembles; NMR; MD simulations
(This special issue belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)
Function and Regulation of Hyaluronan and Hyalectins in Disease: 2nd Edition submission deadline 31 Mar 2027 | Viewed by 8 | Submission Open
Keywords: hyaluronan; glycosaminoglycan; hyalectan; cancer; extracellular matrix; cellular signaling
(This special issue belongs to the Section Chemical Biology)
Biomarkers in Inherited Metabolic Diseases, 3rd Edition
edited by Patryk Lipiński
submission deadline 31 Mar 2027 | Viewed by 4 | Submission Open
Keywords: inherited metabolic diseases; biomarkers; newborn screening; metabolomics; multi-omics; molecular diagnostics; disease monitoring; therapeutic response; precision medicine; variant interpretation
(This special issue belongs to the Section Molecular Biomarkers)
From Computational Design to Experimental Validation: Integrated Workflows in Drug Discovery submission deadline 3 Apr 2027 | Viewed by 65 | Submission Open
Keywords: computer-aided drug design; computational drug discovery; machine learning; artificial intelligence; experimental validation; molecular modeling; structure-based drug design; ligand-based drug design; virtual screening; molecular docking; molecular dynamics; chemoinformatics; QSAR; molecular property prediction; de novo molecular design; medicinal chemistry; hit identification; lead optimization; drug repurposing; structure–activity relationships
(This special issue belongs to the Section Bioinformatics and Systems Biology)
Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery: 3rd Edition submission deadline 10 Apr 2027 | 1 articles | Viewed by 1254 | Submission Open
Keywords: proteins; peptides; amyloid; aptamers; molecular docking; Alzheimer disease; Parkinson’s disease; neurodrugs; biotechnological enzymes; antiviral drugs; vaccines; biomolecular targets; COVID-19; infectious diseases; peptide aggregation; drug repurposing; natural products; synthetic antivirals; anticancer therapeutics
(This special issue belongs to the Section Chemical Biology)
Molecular Biomarkers and Biomolecule-Based Therapies for Rare Diseases: From Mechanistic Discovery to Precision Intervention
edited by and Prem Prakash Kushwaha
submission deadline 10 Apr 2027 | Viewed by 25 | Submission Open
Keywords: rare diseases; molecular biomarkers; biomolecules; multiomics; precision medicine; therapeutic RNA; proteins; metabolites; patient stratification; molecular diagnostics
(This special issue belongs to the Section Molecular Biomarkers)
Biomolecular Insights into Exercise-Induced Modulation of Immunometabolism submission deadline 30 Apr 2027 | 2 articles | Viewed by 6642 | Submission Open
Keywords: biomolecular signaling in exercise adaptation; exercise and immune cell metabolism; inflammatory pathways and exercise; mitochondrial bioenergetics and exercise; exercise and adaptive immunity; neuroimmunometabolism and brain health; exercise and cancer immunometabolism; metabolic biomarkers of exercise-induced immunomodulation
(This special issue belongs to the Section Molecular Biology)
Insights into G-Quadruplexes and I-Motifs: Structure, Dynamics and Function
edited by and Tamaki Endoh
submission deadline 30 Apr 2027 | 4 articles | Viewed by 4857 | Submission Open
Keywords: non-B DNA structures; G-quadruplex; i-motif; nucleic acid structural dynamics; gene regulation; bioinformatics; ligand development; therapeutic applications
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Heterocyclic Compounds: Synthesis, Characterization, and Validation
edited by
submission deadline 30 Apr 2027 | 3 articles | Viewed by 3157 | Submission Open
Keywords: heterocyclic compounds; synthesis; spectroscopy; molecular modeling; biological activity; radiopharmaceuticals
(This special issue belongs to the Section Chemical Biology)
CRISPR-Directed Gene Editing: Molecular Approaches to Cancer Therapeutics
edited by and
submission deadline 30 Apr 2027 | 1 articles | Viewed by 1343 | Submission Open
Keywords: CRISPR; gene editing; genome engineering; cancer therapy; solid tumors; precision medicine; translational research; functional genomics; tumor-specific targeting; CRISPR diagnostics; off-target effects
(This special issue belongs to the Section Molecular Medicine)
Mechanistic Insights of Retinal Diseases and Directions for New Therapeutics
edited by and Neetu Kushwah
submission deadline 30 Apr 2027 | 1 articles | Viewed by 1320 | Submission Open
Keywords: retinopathy; AMD; retinal degeneration; ocular pharmacology; translational therapeutics
(This special issue belongs to the Section Molecular Medicine)
Mesenchymal Stromal Cells in Regenerative Medicine and Immune Modulation: Mechanisms, Engineering, and Therapeutic Applications
edited by
submission deadline 30 Apr 2027 | 1 articles | Viewed by 779 | Submission Open
Keywords: mesenchymal stromal cells; immunomodulation; regenerative medicine; tumor microenvironment; cancer immunotherapy; extracellular vesicles; non‑coding RNAs; engineered MSCs; cell–cell communication
(This special issue belongs to the Section Cellular Biochemistry)
Nanotechnology in Agriculture and the Environment: From Molecular Mechanisms to Sustainable Applications
edited by and Luis Hernandez-Adame
submission deadline 30 Apr 2027 | Viewed by 439 | Submission Open
Keywords: nanotechnology; molecular mechanisms; biomolecules; environment; sustainable agriculture
(This special issue belongs to the Section Bio-Engineered Materials)
Protein Spreading in Neurodegenerative Diseases: From Mechanisms to Therapeutics
edited by and
submission deadline 30 Apr 2027 | Viewed by 322 | Submission Open
Keywords: neurodegeneration; protein aggregation; Alzheimer disease; Lewy bodies; frontotemporal dementia
(This special issue belongs to the Section Molecular Medicine)
Immunohistochemical and Molecular Approaches to Gastrointestinal Disease Characterization submission deadline 30 Apr 2027 | Viewed by 77 | Submission Open
Keywords: gastrointestinal diseases; biomarkers; artificial intelligence; multimodal therapy; immunohistochemistry
(This special issue belongs to the Section Molecular Medicine)
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