Molecular Insights in Immunogenetics: Structure and Evolution of the Antigen Receptors of the Adaptive Immune Response
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Genetics".
Deadline for manuscript submissions: 31 March 2027 | Viewed by 101
Editors
2. Department of Pharmacy-Pharmaceutical Sciences, University of Bari "Aldo Moro", 70125 Bari, Italy
Interests: bioinformatics; immunogenetics; genomics; comparative genomics; functional genomics; microbiology; biological basis of immunity-related disorders (e.g., autoimmunity)
Special Issues, Collections and Topics in MDPI journals
Interests: genetics; immunogenetics; genomics; molecular genetics
Special Issues, Collections and Topics in MDPI journals
Interests: characterization of mitochondrial carriers (MCs); FAD/NADH dehydrogenases structural characterization; MCs in cancer and in rare diseases; structural analysis for investigating MC translocation mechanism and pathogenic mutations; structural analysis for investigating interactions between the protein complex and small molecules; structural analysis for investigating antibody–antigen–receptor interactions and antibody engineering; virtual screening of chemical libraries; ab initio protein structure; protein 3D modeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Immunogenetics provides a mechanistic framework to link genetic diversity with immune function. Within this field, a myriad of immune cells and molecules interact inside a dynamic, complex network to precisely recognize and eliminate a vast array of foreign pathogens. The B and T lymphocytes, along with their respective receptors, serve as a key model system. The diversity of both immunoglobulins and T cell receptors arises from evolutionary processes acting on germline gene repertoires and somatic V(D)J recombination, with somatic hypermutation additionally driving immunoglobulin diversification.
This genetic variability translates into structural diversity, particularly within the complementarity-determining regions (CDRs), an evolutionary and structural hotspot, enabling adaptive recognition of diverse antigens.
Understanding how gene evolution constraints and shapes antibody and T cell receptor structures is essential for deciphering antigen recognition and its dysregulation in disease. This Special Issue aims to integrate evolutionary, genetic, and structural perspectives to elucidate the principles governing antibody/receptor–antigen interactions.
Dr. Pietro D'Addabbo
Dr. Rachele Antonacci
Dr. Ciro Leonardo Pierri
Guest Editors
Manuscript Submission Information
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Keywords
- immunogenetics
- immune response
- genetic variation
- structural interaction
- autoimmunity
- genomics
- transcriptomics
- molecular mechanisms
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