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Biomolecules
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Molecular Factors Involved in Healthy and Diseased States of Skeletal...
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Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Biological Factors".

Deadline for manuscript submissions: 30 March 2027 | Viewed by 713

Special Issue Editors

Dr. Virginia Tancredi

E-Mail Website
Guest Editor
1. Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
2. Centre of Space Biomedicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
Interests: aging; skeleton; muscles; physical activity and wellness; cognitive perception; sport training; quality of life
Special Issues, Collections and Topics in MDPI journals
Dr. Roberto Bonanni

E-Mail Website
Guest Editor
Department of Applied Clinical and Biotechnological Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: muscle atrophy; skeleton; bone; musculoskeletal diseases; physiology; exercise; neurodegeneration; aging
Special Issues, Collections and Topics in MDPI journals
Dr. Ida Cariati

E-Mail Website
Guest Editor
Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, Italy
Interests: exercise; aging; whole body vibration; musculoskeletal diseases; osteoporosis; sarcopenia; neurodegeneration; quality of life
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Skeletal muscle is one of the most extensive tissues in the human body and plays a crucial role in maintaining health, contributing to bodily functions such as locomotion and energy metabolism regulation. Numerous factors, such as lifestyle and age, can have a significant impact on skeletal muscle metabolism, compromising mitochondrial function, satellite cell activity, multinucleated fibre formation, and numerous other processes underlying muscle physiology. Impaired muscle health could have systemic repercussions, as evidence indicates the existence of muscle–multiorgan crosstalk, in which an extensive network of molecular factors promotes biochemical communication between muscle and other organs. Similarly, diseases affecting the bones, brain, or intestines can have a devastating impact on muscle health, leading to atrophy and predisposing individuals to a sedentary lifestyle. However, the identity and role of the numerous molecular factors involved in muscle–multiorgan crosstalk, which is crucial for the balance between muscle health and disease, remain partially unexplored, suggesting the need to deepen our knowledge in this field of research. The identification of biomarkers or potential molecular targets could facilitate the development of strategies to counteract the musculoskeletal decline that occurs during ageing. Therefore, this Special Issue aims to collect original research articles or review articles investigating the molecular factors involved in skeletal muscle health and disease states.

Dr. Virginia Tancredi
Dr. Roberto Bonanni
Dr. Ida Cariati
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skeletal muscle
  • ageing
  • muscle physiology
  • muscle-multiorgan crosstalk
  • muscle health
  • muscle atrophy
  • molecular factors
  • sedentariness
  • exercise

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Published Papers (1 paper)

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Review

22 pages, 975 KB  
Review
Microenvironmental Drivers of Bone Disease in Multiple Myeloma: Oxidative Stress, Sterile Inflammation, Autophagy–Lysosomal Remodeling, and the Iron–Lipid Peroxidation Axis
by Maria Elisa Nasso, Adele Bottaro, Manlio Fazio, Fabio Stagno, Sebastiano Gangemi and Alessandro Allegra
Biomolecules 2026, 16(5), 710; https://doi.org/10.3390/biom16050710 - 12 May 2026
Viewed by 313
Abstract
Multiple myeloma profoundly remodels the bone marrow microenvironment, causing osteolytic bone disease through a persistent uncoupling of bone resorption and formation. Beyond the canonical roles of the receptor activator of nuclear factor kappa-B ligand/receptor activator of nuclear factor kappa-B/osteoprotegerin triad and Wnt antagonism, [...] Read more.
Multiple myeloma profoundly remodels the bone marrow microenvironment, causing osteolytic bone disease through a persistent uncoupling of bone resorption and formation. Beyond the canonical roles of the receptor activator of nuclear factor kappa-B ligand/receptor activator of nuclear factor kappa-B/osteoprotegerin triad and Wnt antagonism, three interdependent stress programs orchestrate the osteolytic niche. These include oxidative stress driven by mitochondrial and nicotinamide adenine dinucleotide phosphate oxidase-derived reactive oxygen species; sterile inflammation sustained by damage-associated molecular patterns, pattern-recognition receptors, and pro-inflammatory cytokines; and autophagy–lysosomal remodeling governed by transcription factor EB and the coordinated lysosomal expression and regulation network. These axes intersect with iron handling and lipid peroxidation to regulate sensitivity to ferroptotic cell death, thereby shaping osteoclast priming, osteoblast suppression, and matrix turnover. Building on these mechanistic insights, we outline a translational framework that aligns standardized bone turnover markers of formation and resorption with composite panels of oxidative and nitrosative stress. This framework also integrates modern imaging to capture structural injury and metabolically active marrow disease. We further propose a therapeutic roadmap layered on antiresorptive foundations that targets selective inhibition of nicotinamide adenine dinucleotide phosphate oxidase 4 and calibrated modulation of nuclear factor erythroid 2–related factor 2, disrupts damage-associated molecular pattern and cytokine circuits, and applies lineage- and timing-specific tuning of autophagy together with restoration of ferroportin-1 or iron chelation. This integrated strategy is designed to recouple bone remodeling and improve clinically meaningful skeletal outcomes in multiple myeloma. Full article
(This article belongs to the Special Issue Molecular Factors Involved in Healthy and Diseased States of Skeletal Muscle: Overview and Perspectives)
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