Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications

Dear Colleagues,

The innate immune system represents the body’s first line of defense against internal and external threats. Highly conserved throughout evolution, innate immune mechanisms have been extensively studied in organisms ranging from Drosophila melanogaster to humans. Pattern-recognition receptors (PRRs) are key mediators that sense pathogen- and danger-associated molecular patterns, enabling the discrimination of self and non-self and triggering protective immune and inflammatory responses. The initiation, amplification, and resolution of inflammation depend on complex interactions among immune and non-immune cells. While controlled inflammation is crucial for pathogen clearance and tissue homeostasis, dysregulated or chronic inflammation contributes to numerous pathological conditions, including autoimmune and inflammatory diseases.

Recently, advances in molecular and cellular immunology have greatly expanded our understanding of innate immune signaling pathways and their role in health and disease. These discoveries are now being translated into innovative therapeutic approaches that modulate innate immune responses. This Special Issue, titled “Innate Immunity and Inflammation: From Molecular Mechanisms to Therapeutic Applications”, will highlight recent progress in deciphering innate immune pathways and explore how this knowledge can be harnessed for therapeutic benefit. We welcome contributions discussing molecular mechanisms, signaling networks, and novel strategies targeting innate immunity for the treatment of infectious, inflammatory, and autoimmune diseases.

Prof. Dr. Simona Pergolizzi
Dr. Anthea Miller
Guest Editors

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