Special Issues

Biomolecules publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Copper Signaling and Redox Biology in Vascular Function and Disease
edited by Archita Das
submission deadline 31 Aug 2026 | Viewed by 192 | Submission Open
Keywords: redox signaling; endothelial cell; vascular biology; angiogenesis; atherosclerosis; diabetes; copper transporter proteins
(This special issue belongs to the Section Molecular Medicine)
The Heme Oxygenase/Biliverdin Reductase System in Human Health and Disease: New Molecular Insights and Therapeutic Targets
edited by Cesare Mancuso
submission deadline 1 Sep 2026 | 6 articles | Viewed by 7380 | Submission Open
Keywords: Alzheimer’s disease; bilirubin; cancer; carbon monoxide; cardiovascular diseases; cerebral malaria; diabetes mellitus; drug research and development; inflammation; Parkinson’s disease
(This special issue belongs to the Section Molecular Medicine)
Molecular Mechanisms and Microenvironmental Regulation in Bone-Related Diseases and Muscle Atrophy
edited by Haitao Wang
submission deadline 1 Sep 2026 | 2 articles | Viewed by 3833 | Submission Open
Keywords: bone diseases; muscle atrophy; osteoporosis; osteoarthritis; osteosarcoma; sarcopenia; heterotopic ossification; molecular mechanisms; microenvironment; therapeutic targets
(This special issue belongs to the Section Molecular Medicine)
Molecular Profiling and Identification of Molecular Signatures Associated with Natural Products: 2nd Edition
edited by
submission deadline 1 Sep 2026 | 1 articles | Viewed by 2797 | Submission Open
Keywords: natural product; molecular mechanisms; repurposed molecules; disease model; human health
Molecular Mechanisms and Drug Research in Alzheimer’s Disease
edited by
submission deadline 1 Sep 2026 | 2 articles | Viewed by 2676 | Submission Open
Keywords: Alzheimer's disease; molecular mechanisms; drug discovery; Aβ amyloid; tau protein; neuroinflammation; oxidative stress; metal homeostasis; blood–brain barrier; dysbiosis
(This special issue belongs to the Section Molecular Medicine)
Cellular and Molecular Mechanisms of Endometriosis: 2nd Edition
edited by , Alessandra Andrisani and Chiara Sabbadin
submission deadline 15 Sep 2026 | 3 articles | Viewed by 6854 | Submission Open
Keywords: endocrine disfunction in endometriosis; glycosylphosphatidylinositols (GPIs) and GPI-anchored proteins; oxidative stress markers (glutathione, carbonic anhydrase, etc.); endometriosis and deep endometriosis; endometriosis-related immune system
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Bronchiolitis Obliterans
edited by Ralf Schubert and Silvija-Pera Jerkic
submission deadline 15 Sep 2026 | 3 articles | Viewed by 3705 | Submission Open
Keywords: bronchiolitis obliterans (BO); inflammation; fibrosis; molecular mechanisms
(This special issue belongs to the Section Molecular Medicine)
Prion Biology and Disease: Molecular Mechanisms and Emerging Technologies
edited by Takashi Onodera and
submission deadline 15 Sep 2026 | Viewed by 1150 | Submission Open
Keywords: prions; PrPC; PrPSc; prion strain diversity; neurodegeneration; immunodetection methods; nonthermal gas plasma; protein misfolding cyclic amplification (PMCA); real-time quaking-induced conversion (RT-QuIC)
Microbial Extracellular Vesicles: From Virulence Factors to Therapeutic Targets
edited by
submission deadline 15 Sep 2026 | Viewed by 582 | Submission Open
Keywords: microbial extracellular vesicles; virulence factors; host–pathogen interaction; drug delivery; biomarkers
Epigenetic and Pharmacological Insights into Cognitive Dysfunction Driven by Genetic and Environmental Factors
edited by
submission deadline 15 Sep 2026 | Viewed by 192 | Submission Open
Keywords: cognitive dysfunction; epigenetic regulation; genetic risk; environmental exposure
(This special issue belongs to the Section Molecular Genetics)
Extracellular Non-Coding RNAs as Key Regulators and Biomarkers in Reproductive Processes
edited by Rosalia Battaglia
submission deadline 15 Sep 2026 | Viewed by 187 | Submission Open
Keywords: extracellular non-coding RNAs; reproductive biology; extracellular vesicles; biomarkers; assisted reproductive technology
(This special issue belongs to the Section Molecular Reproduction)
Targeting Protein Misfolding: From Alzheimer's Amyloids to Therapeutic Peptides submission deadline 16 Sep 2026 | 2 articles | Viewed by 6301 | Submission Open
Keywords: amyloidogenesis; amyloidosis; amyloid fibrils; dissolution of amyloid fibrils; beta-sheet breakers; peptide inhibitors; small molecule inhibitors
Novel Diagnostic Tools and Biomarkers in Hematology
edited by Lars Kaestner
submission deadline 17 Sep 2026 | 1 articles | Viewed by 1302 | Submission Open
Keywords: blood-based biomarkers; diagnostic innovation; omics technologies; microfluidics; photonics; machine learning; hematology; precision medicine
(This special issue belongs to the Section Molecular Biomarkers)
Biotherapeutic Analysis: Precision Characterization and Quality Control
edited by
submission deadline 20 Sep 2026 | 2 articles | Viewed by 2300 | Submission Open
Keywords: biotherapeutics; analytical characterization; quality control; mass spectrometry; cell therapy; gene therapy; biologics; process analytical technology; regulatory science
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Evolutionary Genomics of Bacterial Endosymbionts: From Mutualism to Parasitism
edited by
submission deadline 20 Sep 2026 | 1 articles | Viewed by 2157 | Submission Open
Keywords: host–symbiont coevolution; metabolic pathways; horizontal DNA transfer; phylogenetics
Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery: 3rd Edition submission deadline 20 Sep 2026 | 1 articles | Viewed by 975 | Submission Open
Keywords: proteins; peptides; amyloid; aptamers; molecular docking; Alzheimer disease; Parkinson’s disease; neurodrugs; biotechnological enzymes; antiviral drugs; vaccines; biomolecular targets; COVID-19; infectious diseases; peptide aggregation; drug repurposing; natural products; synthetic antivirals; anticancer therapeutics
(This special issue belongs to the Section Chemical Biology)
Angiogenin: From Molecular Mechanisms to Clinical Implications
edited by
submission deadline 20 Sep 2026 | Viewed by 314 | Submission Open
Keywords: angiogenin; angiogenesis; neuroprotection; cancer; neurodegeneration; biomarker; therapeutic target
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Nitrogen Signaling, Transport, and Function in Plants, 2nd Edition
edited by
submission deadline 20 Sep 2026 | Viewed by 264 | Submission Open
Keywords: nitrogen assimilation; nitrogen sensing; nitrogen transport; nitrogen signaling; primary nitrate response; systemic nitrogen signaling
(This special issue belongs to the Section Biological Factors)
Advances in Molecular Mechanisms of Hearing Loss
edited by
submission deadline 20 Sep 2026 | Viewed by 190 | Submission Open
Keywords: molecular signaling pathways; inflammation in hearing loss; genetic mutations; neurotransmitter dysregulation; cellular mechanotransduction
(This special issue belongs to the Section Molecular Genetics)
CD5 and CD6 Immunobiology: Multitask Immunomodulatory Molecules in Infection, Cancer and Autoimmunity
edited by Lozano Francisco and María Velasco-de Andrés
submission deadline 24 Sep 2026 | 1 articles | Viewed by 1414 | Submission Open
Keywords: CD5; CD6; T cells; B1a cells; NK cells; immunomodulation; infection; cancer; autoimmunity; immunotherapy
(This special issue belongs to the Section Biological Factors)
Functional Analysis of Genes Related to DNA Damage
edited by Ryan P. Barnes and Amy M. Whitaker
submission deadline 25 Sep 2026 | 8 articles | Viewed by 9190 | Submission Open
Keywords: DNA damage; DNA repair; genome stability; DNA replication stress
(This special issue belongs to the Section Molecular Biology)
Dietary Polyphenols and Their Impact on Inflammation and Cardiovascular Metabolic Health
edited by Sonila Alia and
submission deadline 25 Sep 2026 | 1 articles | Viewed by 995 | Submission Open
Keywords: dietary polyphenols; inflammation; cardiometabolic health; cardiovascular diseases; oxidative stress; antioxidant activity; molecular mechanisms; nutritional interventions
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Focus on Perineural Invasion in Pancreatic Cancer
edited by
submission deadline 25 Sep 2026 | Viewed by 559 | Submission Open
Keywords: pancreatic cancer; perineural invasion; pain; NGF; neutrophins
(This special issue belongs to the Section Molecular Medicine)
Endocrine Regulation of Reproductive Tissues: From Molecular Mechanisms to Therapies submission deadline 25 Sep 2026 | Viewed by 480 | Submission Open
Keywords: hormone signaling; reproductive physiology; steroid receptors; infertility; endocrine disruptors; epigenetic regulation; gonadal steroids; hormone-dependent cancers; therapeutic targeting; gametogenesis
(This special issue belongs to the Section Biological Factors)
Advances in Plant Genetic Engineering
edited by
submission deadline 25 Sep 2026 | Viewed by 186 | Submission Open
Keywords: plant genetic engineering and biotechnology; CRISPR-Cas system; precise genome editing; synthetic biology; plant transformation and modification; genetically modified plants; plant improvement; biofactories
(This special issue belongs to the Section Molecular Genetics)
Advances in Drosophila Models for Amyloid and Neurodegenerative Diseases
edited by Ann Christin Brorsson
submission deadline 28 Sep 2026 | 1 articles | Viewed by 1374 | Submission Open
Keywords: neurodegeneration; protein aggregation; amyloid structures; neurotoxicity; Drosophila melanogaster; model organism
Molecular Advances in Wound Healing and Skin Regeneration
edited by and Muhammad Shafiq
submission deadline 30 Sep 2026 | 3 articles | Viewed by 43823 | Submission Open
Keywords: artificial dressings; electrospun fiber-based wound dressings; artificial skin equivalents; wound healing; instructive biomaterials for in situ skin repair; microneedles for skin therapy; drug delivery systems for wound healing; cell-free approaches for skin repair; stem cell therapy for wound healing; scarless skin repair
(This special issue belongs to the Section Biological Factors)
Biologics and Biomaterials for Periodontal Treatment: Current and Future Challenges
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 14382 | Submission Open
Keywords: periodontal disease; periodontitis; periodontal regeneration; periodontal tissue engineering; biological agents; biomaterials
(This special issue belongs to the Section Bio-Engineered Materials)
Feature Papers in Section "Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates"
edited by
submission deadline 30 Sep 2026 | 9 articles | Viewed by 9878 | Submission Open
Keywords: biomacromolecules; proteins; DNA; RNA; chromatin; epigenetics; gene regulation; genomics; proteomics; metabolomics; computational approaches; molecular biotechnology; molecular therapeutics
(This special issue belongs to the Section Biomacromolecules: Proteins, Nucleic Acids and Carbohydrates)
Alcohol-Related Organ Damage: Mechanisms, Outcomes, and Treatment Modalities submission deadline 30 Sep 2026 | 4 articles | Viewed by 9274 | Submission Open
Keywords: alcoholic liver disease (ALD); steatohepatitis; fibrosis; cirhosis; parenhymal and non-parenhymal liver cells; brain; gut; lungs; immune responses; oxidative stress; methylation; viral infections; post-translational protein modifications; treatment of ALD
(This special issue belongs to the Section Molecular Medicine)
The Biomarkers in Renal Diseases
edited by and María Carmen Ruiz Fuentes
submission deadline 30 Sep 2026 | 4 articles | Viewed by 6704 | Submission Open
Keywords: biomarkers; acute kidney injury; chronic kidney disease; microvesicles; exosomes
(This special issue belongs to the Section Molecular Biomarkers)
Natural Products and Their Derivatives with Antiviral Activity
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 6369 | Submission Open
Keywords: natural products; synthetic antivirals; antiviral drugs; antiviral strategies; influenza; HBV; HIV; RSV; COVID-19; SARS-CoV-2
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Deciphering Disease Progression Through Multi-Omics Integration
edited by Cinzia Franchin
submission deadline 30 Sep 2026 | 2 articles | Viewed by 4821 | Submission Open
Keywords: multi-omics integration; systems biology; biomarkers; disease progression; precision medicine; computational modelling
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms Underlying Liver Diseases: 2nd Edition
edited by
submission deadline 30 Sep 2026 | 4 articles | Viewed by 4393 | Submission Open
Keywords: pathogenesis of liver diseases; molecular mechanisms; organelle damages; genetic determinants; organ–organ interactions; biomarkers; in vivo models of liver diseases; therapeutic insights
(This special issue belongs to the Section Cellular Biochemistry)
Mitochondrial ROS in Health and Disease: 2nd Edition
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 4010 | Submission Open
Keywords: aging; apoptosis; respiratory chain; redox signaling; paclitaxel
(This special issue belongs to the Section Chemical Biology)
Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 4006 | Submission Open
Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders
(This special issue belongs to the Section Molecular Medicine)
Advances in the Pathology of Prostate Cancer: 2nd Edition
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 3671 | Submission Open
Keywords: prostate cancer; molecular pathology; biomarker; chemoprevention; therapy
(This special issue belongs to the Section Chemical Biology)
Metallic Nanoparticles: Biosynthesis and Therapeutic Potential submission deadline 30 Sep 2026 | 2 articles | Viewed by 3547 | Submission Open
Keywords: silver nanoparticle; antibacterial agent; green synthesis; therapeutics
(This special issue belongs to the Section Biological Factors)
Fibrinogen and Fibrin in Human Diseases
edited by
submission deadline 30 Sep 2026 | 3 articles | Viewed by 3507 | Submission Open
Keywords: fibrinogen; fibrin; inflammation; cardiovascular; neurological; endothelium; thrombosis; hemostasis; fibrosis
(This special issue belongs to the Section Molecular Biology)
The Role of Heparin in Blood
edited by , and Denisa Cont
submission deadline 30 Sep 2026 | 1 articles | Viewed by 3361 | Submission Open
Keywords: heparin; glycocalyx; anti-inflammatory properties; immunothrombosis; sepsis; inflammation; hemocompatibility; extracorporeal therapies; antiviral activity; heparin-induced thrombocytopenia (HIT)
(This special issue belongs to the Section Molecular Medicine)
Feature Papers in Section “Cellular Biochemistry”, 2nd Edition submission deadline 30 Sep 2026 | 2 articles | Viewed by 3076 | Submission Open
Keywords: cell signalling; cell death; intracellular trafficking (protein, lipids, cytoskeleton, etc.); host–pathogen interactions; extracellular vesicle biology; intercellular communication; autophagy; cellular metabolism; inter-organelle communication; membrane transport; mitochondrial dynamics and function; cell polarity
(This special issue belongs to the Section Cellular Biochemistry)
The Role of Extracellular Vesicles (EVs) in Cell-to-Cell Communication
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2992 | Submission Open
Keywords: extracellular vesicles (EVs); tumorigenesis; initiation; progression; metastasis
(This special issue belongs to the Section Cellular Biochemistry)
Molecular Basis and Oxidative Stress of Thyroid Diseases submission deadline 30 Sep 2026 | 1 articles | Viewed by 2793 | Submission Open
Keywords: thyroid diseases; oxidative stress; reactive oxygen species (ROS); thyroid hormone synthesis; molecular mechanisms; genetic mutations; epigenetic modifications; autoimmune thyroid diseases; Hashimoto thyroiditis; Graves' disease
(This special issue belongs to the Section Biological Factors)
Advanced Therapeutic Strategies for Hormone-Dependent Cancers submission deadline 30 Sep 2026 | 1 articles | Viewed by 2663 | Submission Open
Keywords: hormone-dependent cancers; endocrine therapy resistance; targeted therapy; combination treatment strategies; cancer biomarkers
(This special issue belongs to the Section Molecular Medicine)
Cancer Research: Molecular Insights and Therapeutic Strategies submission deadline 30 Sep 2026 | 3 articles | Viewed by 2400 | Submission Open
Keywords: cancer biology; molecular mechanisms; oncogenic signaling pathways; molecular targets; targeted therapy
(This special issue belongs to the Section Molecular Medicine)
Molecular Regulation of Transcription Factors in Plant Growth and Stress Responses
edited by
submission deadline 30 Sep 2026 | 2 articles | Viewed by 2167 | Submission Open
Keywords: transcription factors; plant growth and development; abiotic and biotic stress; gene regulatory networks; molecular regulation
(This special issue belongs to the Section Molecular Biology)
From Gene to Metabolite: Decoding the Transcriptional Regulatory Networks Controlling the Biosynthesis of Bioactive Compounds
edited by
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1539 | Submission Open
Keywords: bioactive compounds; transcriptional regulation; abiotic and biotic factor; exogenous elicitor
(This special issue belongs to the Section Natural and Bio-derived Molecules)
Molecular Mechanisms and Current Treatment Strategy of Sarcomas submission deadline 30 Sep 2026 | 2 articles | Viewed by 1537 | Submission Open
Keywords: sarcoma; therapeutic vulnerabilities; preclinical models; molecular target
(This special issue belongs to the Section Molecular Medicine)
Future Innovation and Challenges in Bioactive Compounds from Plant Foods: Towards Sustainable Health submission deadline 30 Sep 2026 | 1 articles | Viewed by 1525 | Submission Open
Keywords: bioactive compounds; plant-based foods; functional phytochemicals; sustainable nutrition; nutraceuticals; eco-friendly extraction; agro-industrial byproducts; microalgae and cyanobacteria; food waste valorization; innovative food systems
Mechanisms in Stress-Related Disorders, Anxiety and Fear
edited by Veronica Begni
submission deadline 30 Sep 2026 | 1 articles | Viewed by 1186 | Submission Open
Keywords: stress-related disorders; anxiety; fear; genetic and environmental interactions; behavioral neuroscience; biological pathways; biomarkers; therapeutic interventions
(This special issue belongs to the Section Molecular Biology)
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