Molecular Mechanisms and Microenvironmental Regulation in Bone-Related Diseases and Muscle Atrophy
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: 1 September 2026 | Viewed by 49
Special Issue Editor
Interests: osteoporosis; heterotopic ossification; fibrodysplasia ossificans progressive; age-related bone disease; muscle atrophy; bone marrow stem cells (BMSCs); mesenchymal stem cells (MSCs); skeletal muscle stem cells; telomere alterations/dysfunction; microenvironmental niche; bone regeneration; metabolism study in bone
Special Issue Information
Dear Colleagues,
Bone-related diseases, including osteoporosis, heterotopic ossification, osteoarthritis, osteosarcoma, and bone metastasis, and muscle atrophy conditions, such as sarcopenia, cachexia, and disuse-induced wasting, represent major health challenges with profound societal and economic impacts. Despite significant advances, the molecular mechanisms and microenvironmental cues that govern their initiation and progression remain only partially understood.
The aim of this Special Issue is to provide a platform for original studies and comprehensive reviews that explore the molecular pathways (signaling, metabolic, genetic, and epigenetic) and microenvironmental factors (extracellular matrix remodeling, vascularization, immune and inflammatory responses, and cellular niches) that contribute to these disorders. By integrating mechanistic insights into translational research, this Special Issue will bridge the gap between fundamental biology and clinical applications, fostering the identification of novel biomarkers, therapeutic targets, and regenerative strategies.
We are pleased to invite you to contribute experimental, computational, and clinical perspectives to this Special Issue. We particularly welcome submissions that explore new therapeutic interventions, highlight advances in regenerative medicine, or provide critical overviews of emerging concepts.
This Special Issue will cover the following topics:
- Molecular mechanisms driving bone disease progression;
- Cellular and molecular pathways underlying muscle atrophy;
- Roles of inflammation, oxidative stress, and immune responses;
- Exercise biology and mechanotransduction;
- Epigenetic and transcriptomic regulation in musculoskeletal pathology;
- Stem cell biology and regenerative approaches;
- Novel therapeutic targets and translational strategies;
- Clinical studies connecting molecular insights with therapeutic outcomes.
For this Special Issue, original research articles and reviews are welcome.
Dr. Haitao Wang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bone diseases
- muscle atrophy
- osteoporosis
- osteoarthritis
- osteosarcoma
- sarcopenia
- heterotopic ossification
- molecular mechanisms
- microenvironment
- therapeutic targets
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